Interventional neuroradiology evolved as a new medical subspecialty in the 1980s and focuses on the treatment of cerebrovascular, head and neck, and spinal diseases by using endovascular or other percutaneous routes to reach the target. This field has since tremendously expanded as a result of improved imaging capabilities, technical equipment, and safer contrast media, which brought it to the forefront in the management of aneurysms and various vascular malformations. Anesthesiologists are instrumental in ensuring patient safety and cooperation, thus allowing the interventionalist to focus on the procedure. This chapter is intended to provide the clinical practitioner with background information and specific descriptions of the anatomy, techniques, disorders, and procedures most commonly encountered in interventional neuroradiology.