scholarly journals Cytological grading of breast carcinomas correlating with ultrasonographic findings, histopathologic grade and Her2neu oncogene status in women of age group thirty to sixty five years

2013 ◽  
Vol 02 (04) ◽  
pp. 209-214
Author(s):  
Ena Dowerah ◽  
K L Talukdar
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Age Group ◽  
Breast Carcinomas ◽  
Malignant Tumours ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Breast Lumps

Abstract Background: Breast cancer is a malignant disease with a heterogeneous prognosis. It is the most common cancer in the urban Indian population. Women over 30 years of age are especially prone to develop this type of cancer. There are various prognostic factors that have been studied in invasive ductal carcinomas to predict the tumour behaviour. As fine needle aspiration cytology is an important investigation for diagnosis and grading of the tumour, preoperative evaluation of the tumour behaviour can be studied. Aim: The aim of the study was to diagnose and grade the tumours cytologically by fine needle aspiration cytology (FNAC), to study the tumour behaviour by ultrasonography, by histo pathological examination and also to study the her2neu oncogene overexpression of the malignant tumours. Materials & methods: The present study was carried out in Gauhati Medical College, Guwahati, Assam from May, 2010 to July, 2012. The patients presenting with breast lumps were selected for the study. FNAC smears were stained by Papaniculaou and May Grunwald Giemsa stain. Ultrasonography of the breast lumps were done. Histopathological examination was done using the H & E stain. Immunohistochemical study was done to know the her2neu oncogene overexpression by the tumours. Results & observations: The age of patients with malignant tumours were found in the pre and perimenopausal age group. 48% of the malignant tumours were infiltrating duct carcinoma and of high grade. Her2neu overexpression was seen in 35% of the malignant tumours. Conclusion: A good correlation exists between the cyto-histopathologic grade of the tumours (85.3%), BIRADS 5 category on ultra sonography with histopathologic grade (98.5%) and her2neu oncogene overexpression along with histopathologic grade (93.3%). Therefore, cytological grading indicates an important prognostic marker to know the behaviour of breast carcinomas.

The role of frozen section biopsy for parotid gland tumour with benign fine-needle aspiration cytology

2019 ◽  
Vol 133 (03) ◽  
pp. 227-229 ◽  
Author(s):  
M Suzuki ◽  
Y Nakaegawa ◽  
T Kobayashi ◽  
T Kawase ◽  
T Matsuzuka ◽  
...  
Keyword(s):  
Parotid Gland ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Frozen Section ◽  
Needle Aspiration ◽  
Malignant Tumours ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Gland Tumour

AbstractObjectivesThis study focused on parotid gland tumours diagnosed as benign by fine-needle aspiration cytology and investigated the necessity of frozen section biopsy.MethodsThere were 104 cases of parotid gland tumour where fine-needle aspiration cytology was benign and frozen section biopsy was subsequently performed, between April 2006 and June 2016. In this retrospective study, the results of frozen section biopsy were analysed and compared with the final histological diagnosis.ResultsAmong the 104 cases diagnosed as benign by fine-needle aspiration cytology, 102 cases and 2 cases were diagnosed as benign and malignant, respectively, by frozen section biopsy. The final histological diagnoses showed that 98 cases were benign and 6 cases were malignant. The sensitivity and specificity values of frozen section biopsy in detecting malignant tumours were 33 per cent and 100 per cent, respectively.ConclusionThe necessity of frozen section biopsy in cases with benign fine-needle aspiration cytology may be low in parotid gland surgery.

scholarly journals Fine Needle Aspiration Cytology of Palpable Breast Lumps - Their Cytological Spectrum and Histopathological Correlation

KYAMC Journal ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 780-786
Author(s):  
Shaheen Akter ◽  
Md Jahidul Islam ◽  
Md Shariful Haque
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Breast Lump ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Histopathological Correlation ◽  
Palpable Breast ◽  
Needle Aspiration Cytology ◽  
Breast Lumps

Background: With the advent of fine needle aspiration cytology (FNAC), the approach to diagnosis and management of breast lumps has been revolutionized and it has high sensitivity and specificity.Aim: In this study we analyze the spectrum of FNAC diagnoses in breast lumps and compare the diagnostic accuracy of fine FNAC in differentiating the benign and malignant lesions of breast lumps with histopathological correlation.Materials & Methods: Two years prospective study was conducted in our institution and in that 490 aspirations, including 6 bilateral were performed. Suppurative and inflammatory lesions were excluded from the total aspirates. The cytological diagnosis was classified into 3 groups benign, suspicious and malignant. After this reporting all the available 94 cases were later subjected to mastectomy or open/excision biopsy and followed-up by histopathological confirmation. Later diagnostic accuracy of cytology reporting was compared with that of histopathology.Results: A total of 490 FNAC cases were reported including 373 as benign, 4 as suspicious for carcinoma and 113 as carcinoma. Majorities were premenopausal females and commonest age group was 31-40 years. Among them only 94 cases were followed-up by histopathologic confirmation. In histopathological correlation study, we had accuracy rate of 100% for benign lesion and 92.10% for malignant lesion with false negative rate of 7.90% and false positive rate of zero with fine needle aspiration cytology in the diagnosis of palpable breast lump. The overall sensitivity of fine needle aspiration in diagnosing the palpable breast lump is 92.10%, specificity is 100%, positive predictive value is 100% and negative predictive value is 94.91%.Conclusion: FNAC in experienced hands is a very useful tool with very high specificity and rare false positive result. Sensitivity can be further improved with clinical and imaging correlation.KYAMC Journal Vol. 7, No.-2, Jan 2017, Page 780-786

Critical clinical appraisal of the role of ultrasound guided fine needle aspiration cytology in the management of parotid tumours

2005 ◽  
Vol 119 (4) ◽  
pp. 289-292 ◽  
Author(s):  
Y Bajaj ◽  
S Singh ◽  
N Cozens ◽  
J Sharp
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Malignant Tumours ◽  
Ultrasound Guided ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Parotid Tumours

Objective: Fine needle aspiration cytology is a well established tool for investigating many head and neck conditions. Its application in parotid tumours is, however, controversial. This article is aimed at defining the role of ultrasound guided fine needle aspiration cytology (FNAC) in the diagnostic work up of parotid tumours. The accuracy and utility of FNAC of parotid tumours was also assessed.Design: Retrospective case note review.Setting: District general hospital.Participants: Review of 69 patient records who had parotid surgery under one surgeon’s care (JS). Clinical opinion, FNAC results and final pathology findings were examined.Main outcome measures: The results of the FNAC were compared to the histopathological diagnosis obtained from the surgical specimen.Results: Histological evaluation revealed 13 malignant tumours and 56 benign lesions. The overall sensitivity of FNAC was 84.6 per cent and specificity was 96.4 per cent. We noted 11 true positive, 54 true negative, two false negative and two false positive results. Positive predictive value for diagnosing malignancy was 84.6 per cent and negative predictive value for malignancy was 96.4 per cent. The overall accuracy of FNAC of parotids in this study was 94.2 per cent.Conclusions: FNAC results provide useful preoperative information. FNAC enables more reliable patient counselling and reduces pathological surprises. Pre-operative recognition of malignant tumours may help prepare both the surgeon and patient for an appropriate surgical procedure. Its enhancement of the pre-operative recognition of malignant parotid tumours may alert more stringent attention to the operative margin and hence better tumour clearance. Ultrasound guided FNAC was found to be highly specific for malignancy and its sensitivity for malignancy was good.

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