Fine Needle Aspiration Cytology of Breast Lumps-A correlation with histopathology diagnosis

2016 ◽  
Vol 3 (1) ◽  
pp. 103
Author(s):  
Sonali Saraf ◽  
Manisha Khare ◽  
Alka Kalgutkar
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Breast Lumps

scholarly journals Fine Needle Aspiration Cytology of Palpable Breast Lumps - Their Cytological Spectrum and Histopathological Correlation

KYAMC Journal ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 780-786
Author(s):  
Shaheen Akter ◽  
Md Jahidul Islam ◽  
Md Shariful Haque
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Breast Lump ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Histopathological Correlation ◽  
Palpable Breast ◽  
Needle Aspiration Cytology ◽  
Breast Lumps

Background: With the advent of fine needle aspiration cytology (FNAC), the approach to diagnosis and management of breast lumps has been revolutionized and it has high sensitivity and specificity.Aim: In this study we analyze the spectrum of FNAC diagnoses in breast lumps and compare the diagnostic accuracy of fine FNAC in differentiating the benign and malignant lesions of breast lumps with histopathological correlation.Materials & Methods: Two years prospective study was conducted in our institution and in that 490 aspirations, including 6 bilateral were performed. Suppurative and inflammatory lesions were excluded from the total aspirates. The cytological diagnosis was classified into 3 groups benign, suspicious and malignant. After this reporting all the available 94 cases were later subjected to mastectomy or open/excision biopsy and followed-up by histopathological confirmation. Later diagnostic accuracy of cytology reporting was compared with that of histopathology.Results: A total of 490 FNAC cases were reported including 373 as benign, 4 as suspicious for carcinoma and 113 as carcinoma. Majorities were premenopausal females and commonest age group was 31-40 years. Among them only 94 cases were followed-up by histopathologic confirmation. In histopathological correlation study, we had accuracy rate of 100% for benign lesion and 92.10% for malignant lesion with false negative rate of 7.90% and false positive rate of zero with fine needle aspiration cytology in the diagnosis of palpable breast lump. The overall sensitivity of fine needle aspiration in diagnosing the palpable breast lump is 92.10%, specificity is 100%, positive predictive value is 100% and negative predictive value is 94.91%.Conclusion: FNAC in experienced hands is a very useful tool with very high specificity and rare false positive result. Sensitivity can be further improved with clinical and imaging correlation.KYAMC Journal Vol. 7, No.-2, Jan 2017, Page 780-786

scholarly journals Cytological grading of breast carcinomas correlating with ultrasonographic findings, histopathologic grade and Her2neu oncogene status in women of age group thirty to sixty five years

2013 ◽  
Vol 02 (04) ◽  
pp. 209-214
Author(s):  
Ena Dowerah ◽  
K L Talukdar
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Age Group ◽  
Breast Carcinomas ◽  
Malignant Tumours ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Breast Lumps

Abstract Background: Breast cancer is a malignant disease with a heterogeneous prognosis. It is the most common cancer in the urban Indian population. Women over 30 years of age are especially prone to develop this type of cancer. There are various prognostic factors that have been studied in invasive ductal carcinomas to predict the tumour behaviour. As fine needle aspiration cytology is an important investigation for diagnosis and grading of the tumour, preoperative evaluation of the tumour behaviour can be studied. Aim: The aim of the study was to diagnose and grade the tumours cytologically by fine needle aspiration cytology (FNAC), to study the tumour behaviour by ultrasonography, by histo pathological examination and also to study the her2neu oncogene overexpression of the malignant tumours. Materials & methods: The present study was carried out in Gauhati Medical College, Guwahati, Assam from May, 2010 to July, 2012. The patients presenting with breast lumps were selected for the study. FNAC smears were stained by Papaniculaou and May Grunwald Giemsa stain. Ultrasonography of the breast lumps were done. Histopathological examination was done using the H & E stain. Immunohistochemical study was done to know the her2neu oncogene overexpression by the tumours. Results & observations: The age of patients with malignant tumours were found in the pre and perimenopausal age group. 48% of the malignant tumours were infiltrating duct carcinoma and of high grade. Her2neu overexpression was seen in 35% of the malignant tumours. Conclusion: A good correlation exists between the cyto-histopathologic grade of the tumours (85.3%), BIRADS 5 category on ultra sonography with histopathologic grade (98.5%) and her2neu oncogene overexpression along with histopathologic grade (93.3%). Therefore, cytological grading indicates an important prognostic marker to know the behaviour of breast carcinomas.

scholarly journals Comparison between histopathology and fine needle aspiration cytology in the case of breast lumps

2019 ◽  
Vol 6 (11) ◽  
pp. 4095
Author(s):  
Vishnu V. K. ◽  
Ashwini R. K. ◽  
S. Rajagopalan
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Diagnostic Method ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Medical College ◽  
Needle Aspiration Cytology ◽  
Breast Lumps ◽  
A Prospective Study

Background: Breast lump is one of the common pathologies seen in surgical practice. Hence it is of importance to have a reliable diagnostic method to distinguish between benign and malignant lumps. Aim of this study was to bring out fine needle aspiration cytology (FNAC) as a rapid, inexpensive, accurate and least invasive diagnostic method for this purpose.Methods: A prospective study conducted between December 2017 to November 2018 on all 30 patients admitted at Rajarajeswari Medical College and Hospital with breast lumps. Patients were subjected to clinical examination FNAC and Histopathology.Results: Clinically 64% were categorized as benign lumps and 36% malignant. On FNAC 64% were fibroadenoma, 30% suggestive of malignancy and 6% suspicious of malignancy. On Histopathology 60% were fibroadenoma, 33% turned out to be carcinoma and 7% benign phyllodes. 4% of benign lesions on FNAC turned out malignant on histopathology.Conclusions: Although son mammography is the conventional approach with a sensitivity of 76.5% and specificity of 90.48%, in this study FNAC was found to have sensitivity of 96.6% and specificity of 100% and can be a reliable tool for early diagnosis in the case of breast lumps.

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