scholarly journals Morquio Syndrome Presenting with Dural Band Pathology: A Case Report

2020 ◽  
Vol 12 (04) ◽  
pp. 285-288
Author(s):  
Saloni Gupta ◽  
Kangana Sengar ◽  
Arulselvi Subramanian ◽  
Gurudatta Satyarthee
Keyword(s):  
Case Report ◽  
Clinical Features ◽  
Histopathological Examination ◽  
Keratan Sulfate ◽  
Foramen Magnum ◽  
The Body ◽  
Connective Tissues ◽  
Morquio Syndrome ◽  
Morquio Syndrome A ◽  
Cervicomedullary Compression

AbstractMorquio syndrome is caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS) enzyme, which is required for the catabolism of glycosaminoglycans (namely, chondroitin-6-sulfate and keratan sulfate). Pathogenic accumulation of these glycosaminoglycans occurs throughout the body. The various organs and tissues affected are bones, cartilage, tendon, teeth, trachea and lungs, heart, cornea, skin and connective tissues.Here, we present a case of Morquio syndrome. A 16-year-old boy presented with multiple skeletal abnormalities, including cervicomedullary compression by dorsal dural band in foramen magnum. The dural band was resected during the surgery to relieve compression and sent for histopathological examination. This case report not only reviews the clinical features and shows rare dural band histopathological findings but also mentions a note on the future therapies of this syndrome.

Anesthetic management for foramen magnum decompression in a patient with Morquio syndrome: a case report

2010 ◽  
Vol 24 (4) ◽  
pp. 594-597 ◽  
Author(s):  
Lakshminarsimhaiah Geetha ◽  
Muthuchellappan Radhakrishnan ◽  
Biligiri Sridhar Raghavendra ◽  
G. S. Umamaheswara Rao ◽  
Bhagavatula Indira Devi
Keyword(s):  
Case Report ◽  
Anesthetic Management ◽  
Foramen Magnum ◽  
Foramen Magnum Decompression ◽  
Morquio Syndrome ◽  
Morquio Syndrome A

scholarly journals Cystic compound odontoma in a dog: Diagnosis and management

2021 ◽  
Author(s):  
I Janus ◽  
M Janeczek ◽  
S Dzimira
Keyword(s):  
Case Report ◽  
Oral Cavity ◽  
Clinical Features ◽  
Surgical Management ◽  
Histopathological Examination ◽  
Bone Cyst ◽  
Rare Condition ◽  
Metastatic Potential ◽  
Acceptable Method ◽  
Compound Odontoma

Tumour of the oral cavity is a rare condition in young animals. The most frequent are odontomas – locally invasive tumours with no metastatic potential. The article describes a case report of 4-month-old male puppy diagnosed with mandibular odontoma with cystic appearance. Authors present clinical features, histopathological examination of odontoma and the surgical management using deep curettage and hydroxyapatite granules deposition. Odontomas can form bone cyst-like structure padded with membrane forming denticles. A deep curettage is acceptable method of treatment but should be supplied with hydroxyapatite deposition if the cyst is present.

Reply to the comment of Alkan Melikoglu ‘Joint manifestations can provide diagnostic clues in Morquio syndrome, a case report’

2019 ◽  
Vol 86 (1) ◽  
pp. 123-124
Author(s):  
Stéphane Mitrovic ◽  
Hélène Gouze ◽  
Thierry Schaeverbeke ◽  
Laure Gossec ◽  
Bruno Fautrel
Keyword(s):  
Case Report ◽  
Morquio Syndrome ◽  
Morquio Syndrome A

scholarly journals Sequential metastasis to the liver and pancreas 4 years after gestational trophoblastic neoplasia: a case report

2020 ◽  
Vol 48 (11) ◽  
pp. 030006052096680
Author(s):  
Shuai Yin ◽  
Jiwei Qin ◽  
Qingqing Zhou ◽  
Chenchen Zhu ◽  
Yuebo Li ◽  
...  
Keyword(s):  
Case Report ◽  
Histopathological Examination ◽  
Primary Tumour ◽  
Salvage Chemotherapy ◽  
Primary Diagnosis ◽  
The Body ◽  
Comprehensive Treatment ◽  
Gestational Trophoblastic Neoplasia ◽  
Placental Site ◽  
Metastatic Sites

This case report describes a 43-year-old female initially diagnosed with gestational trophoblastic neoplasia that then experienced metastasis to the liver and then subsequently to the pancreas nearly 4 years after the primary diagnosis. After resection of the body and tail of the pancreas, the postoperative histopathological examination confirmed a placental site trophoblastic tumour that had developed after several cycles of chemotherapy for the original primary tumour and the liver metastases. This type of sequential recurrence of gestational trophoblastic neoplasia in the primary site or metastatic sites, such as the liver or pancreas, can be cured by a comprehensive treatment strategy involving surgery and/or salvage chemotherapy and continuous follow-up over a long period, especially for patients with a high-risk status.

scholarly journals Morquio Syndrome: A Case Report

Cureus ◽  
2018 ◽  
Author(s):  
Kamleshun Ramphul ◽  
Stephanie G Mejias ◽  
Yogeshwaree Ramphul-Sicharam
Keyword(s):  
Case Report ◽  
Morquio Syndrome ◽  
Morquio Syndrome A

scholarly journals PRP therapy in chronic diffuse alopecia areata – A case report

2021 ◽  
Vol 7 (4) ◽  
pp. 363-366
Author(s):  
Kashish Tyagi ◽  
Sheilly Kapoor ◽  
Ishani Mohapatra ◽  
Komal Sharma
Keyword(s):  
Case Report ◽  
Alopecia Areata ◽  
Hair Growth ◽  
Histopathological Examination ◽  
Hair Follicles ◽  
The Body ◽  
Treatment Modalities ◽  
Immune Disorder ◽  
Excellent Response

Alopecia areata, an auto-immune disorder characterised by the appearance of non-scarring bald patches affecting the hair bearing areas of the body, it can be extremely difficult to treat and has a poor prognosis despite many therapeutic options. Platelet Rich Plasma (PRP) has been previously used to treat variety of alopecia including alopecia areata. A 21-year old girl presented with asymptomatic loss of hair from the scalp for the last more than two years. On examination, there was diffuse loss of hair all over the scalp with few small, thin light-coloured hair in the occipital region. Histopathological examination showed miniaturised hair follicles surrounded by variable inflammatory lymphohistiocytic infiltrate with a marked reduction in terminal-vellus hair ratio to 1:1.The response to previous treatments was poor at the end of 1 year. A trial of PRP was given with no adjuvant treatment with a total of eight sessions of PRP. Dramatic response was noted after 2 sessions in the form of improvement in hair diameter and total volume. Resistant areas also started showing hair growth. There are a few studies assessing the role of PRP therapy in AA. First report to establish the efficacy of PRP as a treatment modality in AA, showed PRP therapy to be superior to TCA and Placebo in growing pigmented hair in AA patches. A case report with ophiasis type AA resistant to intralesional steroid injections showed excellent response to PRP therapy. Previous studies have demonstrated beneficial role of PRP therapy in cases of patchy alopecia areata, in contrast ours was a case of chronic diffuse AA. Inspite of many treatment modalities tried for more than a year, the response was unsatisfactory. PRP therapy yielded amazing results in the form of hair growth over resistant areas and overall increase in pigmented hair which were sustained at one and a half year follow up. Our case was unique in the way that excellent response to PRP treatment was noted (a) In a case of diffuse alopecia areata. (b) In a case non- responsive to standard modalities. (c) In a case with no other supportive treatment.

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