scholarly journals Incidental colorectal focal 18F-FDG uptake: a novel indication for colonoscopy

2017 ◽  
Vol 05 (09) ◽  
pp. E924-E930 ◽  
Author(s):  
Eugénie Rigault ◽  
Laurence Lenoir ◽  
Guillaume Bouguen ◽  
Mael Pagenault ◽  
Astrid Lièvre ◽  
...  
Keyword(s):  
False Positive ◽  
Fdg Pet ◽  
True Positive ◽  
Fdg Uptake ◽  
Endoscopic Findings ◽  
Pet Ct ◽  
Uptake Sites ◽  
Malignant Lesions ◽  
18F Fdg ◽  
Fdg Pet Ct

Abstract Background and study aims The relevance of incidental colorectal focal 18F-FDG PET/CT uptake is debatable. All patients who were referred for colonoscopy because of incidental colonic focal FDG uptake were included in this retrospective study. Patients and methods PET/CT imaging characteristics were reviewed by a nuclear physician who was blinded to endoscopic and histopathological findings to determine the location of FDG uptake sites and to measure the maximum standardized uptake values (SUVmax) and metabolic volume (MV). Endoscopic findings were categorized as malignant lesions (ML), high-risk polyps (HRP), low-risk polyps (LRP) or other non-neoplastic lesions (NNL). Results Seventy patients with 84 foci of FDG uptake were included. The proportions of true-positive (lesions found at colonoscopy at the same location) and false-positive (no lesion at colonoscopy) PET/CT findings were 65.5 % (n = 55) and 34.5 % (n = 29). Median SUVmax values did not differ between true-positive and false-positive findings (P = 0.27). Median MV30 values differed significantly between true-positive (5.5 cm3, [3.3 – 10.9 cm3]) and false-positive (9.7 cm3, [5.2 – 40.8 cm3]) findings (P = 0.015). Among the 55 true-positive FDG uptake sites, there were 14 (25.5 %) malignant lesions, 30 (54.5 %) HRP, 4 (7.3 %) LRP, and 7 (12.7 %) NNL. Median MV30 values differed significantly between advanced neoplasia (5.0 cm3, [2.9 – 9.7 cm3]) and other endoscopic findings (9.4 cm3, [5.2 – 39.8 cm3]) (P = 0.001); the AUROC was 0.71. By per-colonic segment analysis, the distribution of true-positive, false-negative, false-positive, and true-negative FDG PET/CT findings was as follows: 21.5 %, 14.2 %, 11.5 %, and 52.8 %, respectively. Conclusion Our study demonstrates that follow-up complete colonoscopy is mandatory in all patients with incidental colorectal focal 18F-FDG PET/CT uptake.

scholarly journals Diagnostic and prognostic value of 99mTc-Tektrotyd scintigraphy and 18F-FDG PET/CT in a single-center cohort of neuroendocrine tumors

2021 ◽  
Author(s):  
Jelena Saponjski ◽  
Djuro Macut ◽  
Nebojša Petrovic ◽  
Sanja Ognjanovic ◽  
Bojana Popovic ◽  
...  
Keyword(s):  
False Positive ◽  
Fdg Pet ◽  
False Negative ◽  
Progression Free Survival ◽  
True Positive ◽  
True Negative ◽  
Free Survival ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

IntroductionThe aim was to assess the diagnostic value of 99mTc-Tektrotyd scintigraphy (TCT) and positron emission tomography/computed tomography using F-18 fluorodeoxyglucose (18F-FDG PET/CT) in the detection and follow-up of neuroendocrine tumors (NETs), and their predictive value for disease progression.Material and methodsIn this retrospective cohort, TCT and 18F-FDG PET/CT were performed in 90 patients (37 men, 53 women, mean age 52.7 ±15.1), with NET. Correlation of Ki67 and tumor grade versus Krenning score and SUVmax was assessed, Kaplan-Meier analysis was used for progression-free survival (PFS), and Cox regression analysis was performed to identify the association between progression-related factors and PFS.ResultsOut of 90, true positive TCT was detected in 56 (62.2%) patients, true negative in 19 (21.1%), false positive in 4 (4.4%), false negative in 11 (12.2%), while 18F-FDG PET/CT was true positive in 69 (76.7%) patients, true negative in 10 (11.1%), false positive in 5 (5.5%), false negative in 6 (6.7%). Mean 18F-FDG PET/CT SUVmax was 6.8 ±6.2. Diagnostic sensitivity of TCT was 83.6%, specificity 82.6%, accuracy 83.3% vs. 18F-FDG PET/CT sensitivity was 92.0%, specificity 66.7%, accuracy 87.8%. A significant correlation between Ki67 and SUVmax was found in positive 18F-FDG PET/CT findings, unlike the correlation between Ki67 and Krenning score. Median PFS was 25 months (95% CI: 18.2–31.8), in 18F-FDG PET/CT positive patients 23 months (95% CI: 16.3–29.7) and 18F-FDG PET/CT negative 26 months (p = 0.279). Progression-free survival predictors were SUVmax and Krenning score.ConclusionsIn our study, TCT and 18F-FDG PET/CT have high diagnostic accuracy in detection of NET. Higher Krenning score on TCT and SUVmax in positive 18F-FDG PET/CT findings are predictors of disease progression. 99mTc-Tektrotyd scintigraphy and 18F-FDG PET/CT can be useful complementary tools in management of patients with NETs and in predicting patients’ outcome.

scholarly journals Pulmonary Findings of [18F]FDG PET/CT Images on Asymptomatic COVID-19 Patients

Pathogens ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 839
Author(s):  
Tzu-Chuan Ho ◽  
Chin-Chuan Chang ◽  
Hung-Pin Chan ◽  
Ying-Fong Huang ◽  
Yi-Ming Arthur Chen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Fdg Pet ◽  
Standardized Uptake Value ◽  
Fdg Uptake ◽  
Asymptomatic Patients ◽  
Positron Emission ◽  
Pet Ct ◽  
18F Fdg ◽  
Maximal Standardized Uptake Value ◽  
Fdg Pet Ct

During the coronavirus disease 2019 (COVID-19) pandemic, several case studies demonstrated that many asymptomatic patients with COVID-19 underwent fluorine-18 fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) examination for various indications. However, there is a lack of literature to characterize the pattern of [18F]FDG PET/CT imaging on asymptomatic COVID-19 patients. Therefore, a systematic review to analyze the pulmonary findings of [18F]FDG PET/CT on asymptomatic COVID-19 patients was conducted. This systematic review was performed under the guidelines of PRISMA. PubMed, Medline, and Web of Science were used to search for articles for this review. Articles with the key words: “asymptomatic”, “COVID-19”, “[18F]FDG PET/CT”, and “nuclear medicine” were searched for from 1 January 2020 to 20 May 2021. Thirty asymptomatic patients with COVID-19 were included in the eighteen articles. These patients had a mean age of 62.25 ± 14.85 years (male: 67.71 ± 12.00; female: 56.79 ± 15.81). [18F]FDG-avid lung lesions were found in 93.33% (28/30) of total patients. The major lesion was [18F]FDG-avid multiple ground-glass opacities (GGOs) in the peripheral or subpleural region in bilateral lungs, followed by the consolidation. The intensity of [18F]FDG uptake in multiple GGOs was 5.605 ± 2.914 (range from 2 to 12) for maximal standardized uptake value (SUVmax). [18F]FDG-avid thoracic lymph nodes (LN) were observed in 40% (12/40) of the patients. They mostly appeared in both mediastinal and hilar regions with an SUVmax of 5.8 ± 2.93 (range from 2.5 to 9.6). The [18F]FDG uptake was observed in multiple GGOs, as well as in the mediastinal and hilar LNs. These are common patterns in PET/CT of asymptomatic patients with COVID-19.

A Few Cases of Increased FDG Uptake on 18F-FDG PET/CT in Residual Lesions of Tuberculosis at the Time of Treatment Completion

CHEST Journal ◽  
2015 ◽  
Vol 148 (4) ◽  
pp. 168A
Author(s):  
MYUNGSUN LEE ◽  
Ina Jung ◽  
Youngran Kim ◽  
Jiyeon Lee
Keyword(s):  
Fdg Pet ◽  
Treatment Completion ◽  
Fdg Uptake ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Residual Lesions

Benign High-Flow Priapism With a Diffuse and Intense 18F-FDG Uptake on 18F-FDG PET/CT Scanning

2019 ◽  
Vol 44 (7) ◽  
pp. e442-e444
Author(s):  
Zakieh Nasiri ◽  
Soroush Zarehparvar Moghadam ◽  
Zahra Kiamanesh ◽  
Farshad Emami ◽  
Ramin Sadeghi
Keyword(s):  
Fdg Pet ◽  
Ct Scanning ◽  
High Flow ◽  
Fdg Uptake ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

False-Positive Finding on 18F FDG PET/CT

2016 ◽  
Vol 41 (9) ◽  
pp. 722-723 ◽  
Author(s):  
Mohammed Shah Alam ◽  
Wei Guan ◽  
Wen-lan Zhou ◽  
Quan-shi Wang ◽  
Hu-bing Wu
Keyword(s):  
False Positive ◽  
Fdg Pet ◽  
Positive Finding ◽  
False Positive Finding ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Thyroid lesions incidentally detected by 18F-FDG PET-CT ― a two centre retrospective study

2015 ◽  
Vol 49 (2) ◽  
pp. 121-127 ◽  
Author(s):  
Jan Jamsek ◽  
Ivana Zagar ◽  
Simona Gaberscek ◽  
Marko Grmek
Keyword(s):  
Fdg Pet ◽  
Malignant Lesion ◽  
Standardized Uptake Value ◽  
Benign Lesions ◽  
Fdg Uptake ◽  
Pet Ct ◽  
Thyroid Uptake ◽  
Malignant Lesions ◽  
Fdg Pet Ct ◽  
Thyroid Lesions

AbstractBackground. Incidental18F-FDG uptake in the thyroid on PET-CT examinations represents a diagnostic challenge. The maximal standardized uptake value (SUVmax) is one possible parameter that can help in distinguishing between benign and malignant thyroid PET lesions.Patients and methods. We retrospectively evaluated18F-FDG PET-CT examinations of 5,911 patients performed at two different medical centres from 2010 to 2011. If pathologically increased activity was accidentally detected in the thyroid, the SUVmaxof the thyroid lesion was calculated. Patients with incidental18F-FDG uptake in the thyroid were instructed to visit a thyroidologist, who performed further investigation including fine needle aspiration cytology (FNAC) if needed. Lesions deemed suspicious after FNAC were referred for surgery.Results. Incidental18F-FDG uptake in the thyroid was found in 3.89% ― in 230 out of 5,911 patients investigated on PET-CT. Malignant thyroid lesions (represented with focal thyroid uptake) were detected in 10 of 66 patients (in 15.2%). In the first medical centre the SUVmaxof 36 benign lesions was 5.6 ± 2.8 compared to 15.8 ± 9.2 of 5 malignant lesions (p < 0.001). In the second centre the SUVmaxof 20 benign lesions was 3.7 ± 2.2 compared to 5.1 ± 2.3 of 5 malignant lesions (p = 0.217). All 29 further investigated diffuse thyroid lesions were benign.Conclusions. Incidental18F-FDG uptake in the thyroid was found in 3.89% of patients who had a PET-CT examination. Only focal thyroid uptake represented a malignant lesion in our study ― in 15.2% of all focal thyroid lesions. SUVmaxshould only serve as one of several parameters that alert the clinician on the possibility of thyroid malignancy.

False positive 18F-FDG-PET/CT in a patient after talc pleurodesis

Lung Cancer ◽  
2007 ◽  
Vol 58 (3) ◽  
pp. 418-421 ◽  
Author(s):  
Hojjat Ahmadzadehfar ◽  
Holger Palmedo ◽  
Holger Strunk ◽  
Hans-Jürgen Biersack ◽  
Elham Habibi ◽  
...  
Keyword(s):  
False Positive ◽  
Fdg Pet ◽  
Talc Pleurodesis ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Correlation of Clinical and Endoscopic Evaluation with PET-CT in Detecting Recurrence of Head and Neck Squamous Cell Carcinoma

2018 ◽  
Vol 26 (2) ◽  
pp. 105-111
Author(s):  
Rambabu Mappuri ◽  
Ramakrishnan Narayanaswamy
Keyword(s):  
Squamous Cell Carcinoma ◽  
False Positive ◽  
Fdg Pet ◽  
High Sensitivity ◽  
Primary Treatment ◽  
Endoscopic Evaluation ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Introduction The current study reports the correlation of clinical and endoscopic evaluation with 18F-Fluorine Fluorodeoxyglucose Positron emission tomography/Computed tomography (18F-FDG PET/CT) findings in detecting the residual/recurrence tumor after definitive treatment in the follow up cases of squamous cell carcinoma head and neck. Materials and Methods A prospective comparative study carried out on 30 follow-up cancer patients after definitive primary treatment. All patients were evaluated by clinical examination, endoscopy and 18F-FDG PET/CT and these results correlated to detect residual/recurrence. Suspicious lesion at primary site suggesting residual/recurrence was confirmed by gold standard investigation, histopathological examination (HPE).   Result The age group mostly involved is 40-70 with male predominance. Predominant sites were oral cavity and larynx. 20 patients showed recurrence on clinical and endoscopic evaluation with 03 false positive results, 10 patients showed no recurrence with 01 false negative result. On PET/CT, 19 patients were showed recurrence with 01 false positive result, 11 patients showed no recurrence. PET/CT showed high sensitivity, specificity, with high NPV in detecting the recurrence of disease in the follow up period. Clinical and endoscopic evaluation also has high sensitivity, PPV and NPV. Conclusion It is recommended that 18F-FDG PET/CT scan should be done in every case after primary treatment in addition to complete clinical and endoscopic evaluation and during follow-up period for early detection and management of residual/ recurrence.

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