A Few Cases of Increased FDG Uptake on 18F-FDG PET/CT in Residual Lesions of Tuberculosis at the Time of Treatment Completion

During the coronavirus disease 2019 (COVID-19) pandemic, several case studies demonstrated that many asymptomatic patients with COVID-19 underwent fluorine-18 fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) examination for various indications. However, there is a lack of literature to characterize the pattern of [18F]FDG PET/CT imaging on asymptomatic COVID-19 patients. Therefore, a systematic review to analyze the pulmonary findings of [18F]FDG PET/CT on asymptomatic COVID-19 patients was conducted. This systematic review was performed under the guidelines of PRISMA. PubMed, Medline, and Web of Science were used to search for articles for this review. Articles with the key words: “asymptomatic”, “COVID-19”, “[18F]FDG PET/CT”, and “nuclear medicine” were searched for from 1 January 2020 to 20 May 2021. Thirty asymptomatic patients with COVID-19 were included in the eighteen articles. These patients had a mean age of 62.25 ± 14.85 years (male: 67.71 ± 12.00; female: 56.79 ± 15.81). [18F]FDG-avid lung lesions were found in 93.33% (28/30) of total patients. The major lesion was [18F]FDG-avid multiple ground-glass opacities (GGOs) in the peripheral or subpleural region in bilateral lungs, followed by the consolidation. The intensity of [18F]FDG uptake in multiple GGOs was 5.605 ± 2.914 (range from 2 to 12) for maximal standardized uptake value (SUVmax). [18F]FDG-avid thoracic lymph nodes (LN) were observed in 40% (12/40) of the patients. They mostly appeared in both mediastinal and hilar regions with an SUVmax of 5.8 ± 2.93 (range from 2.5 to 9.6). The [18F]FDG uptake was observed in multiple GGOs, as well as in the mediastinal and hilar LNs. These are common patterns in PET/CT of asymptomatic patients with COVID-19.

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Benign High-Flow Priapism With a Diffuse and Intense 18F-FDG Uptake on 18F-FDG PET/CT Scanning

Clinical Nuclear Medicine ◽

10.1097/rlu.0000000000002616 ◽

2019 ◽

Vol 44 (7) ◽

pp. e442-e444

Author(s):

Zakieh Nasiri ◽

Soroush Zarehparvar Moghadam ◽

Zahra Kiamanesh ◽

Farshad Emami ◽

Ramin Sadeghi

Keyword(s):

Fdg Pet ◽

Ct Scanning ◽

High Flow ◽

Fdg Uptake ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Diagnostic value of navigation-guided core needle biopsy in deep regions of the head and neck with focal FDG uptake on 18F-FDG PET/CT

Journal of Cranio-Maxillofacial Surgery ◽

10.1016/j.jcms.2020.02.009 ◽

2020 ◽

Vol 48 (5) ◽

pp. 508-513

Author(s):

Ya Gao ◽

Wen-Jie Wu ◽

Lei Zheng ◽

Ming-Wei Huang ◽

Shu-Ming Liu ◽

...

Keyword(s):

Head And Neck ◽

Core Needle Biopsy ◽

Fdg Pet ◽

Needle Biopsy ◽

Diagnostic Value ◽

Core Needle ◽

Fdg Uptake ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Phenotyping Type 2 Diabetes in Terms of Myocardial Insulin Resistance and Its Potential Cardiovascular Consequences: A New Strategy Based on 18F-FDG PET/CT

Journal of Personalized Medicine ◽

10.3390/jpm12010030 ◽

2022 ◽

Vol 12 (1) ◽

pp. 30

Author(s):

José Raul Herance ◽

Rafael Simó ◽

Mayra Alejandra Velasquez ◽

Bruno Paun ◽

Daniel García-Leon ◽

...

Keyword(s):

Insulin Resistance ◽

Type 2 Diabetes ◽

Fdg Pet ◽

Cardiovascular Events ◽

Fdg Uptake ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct ◽

Myocardial Insulin Resistance

Background: Systemic insulin resistance is generally postulated as an independent risk factor of cardiovascular events in type 2 diabetes (T2D). However, the role of myocardial insulin resistance (mIR) remains to be clarified. Methods: Two 18F-FDG PET/CT scans were performed on forty-three T2D patients at baseline and after hyperinsulinemic–euglycemic clamp (HEC). Myocardial insulin sensitivity (mIS) was determined by measuring the increment in myocardial 18F-FDG uptake after HEC. Coronary artery calcium scoring (CACs) and myocardial radiodensity (mRD) were assessed by CT. Results: After HEC, seventeen patients exhibited a strikingly enhancement of myocardial 18F-FDG uptake and twenty-six a marginal increase, thus revealing mIS and mIR, respectively. Patients with mIR showed higher mRD (HU: 38.95 [33.81–44.06] vs. 30.82 [21.48–38.02]; p = 0.03) and CACs > 400 (AU: 52% vs. 29%; p = 0.002) than patients with mIS. In addition, HOMA-IR and mIS only showed a correlation in those patients with mIR. Conclusions: 18F-FDG PET combined with HEC is a reliable method for identifying patients with mIR. This subgroup of patients was found to be specifically at high risk of developing cardiovascular events and showed myocardial structural changes. Moreover, the gold-standard HOMA-IR index was only associated with mIR in this subgroup of patients. Our results open up a new avenue for stratifying patients with cardiovascular risk in T2D.

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18F-FDG PET/CT With Diffusely High FDG Uptake Throughout Subcutaneous Adipose Tissues

Clinical Nuclear Medicine ◽

10.1097/rlu.0000000000002216 ◽

2018 ◽

Vol 43 (10) ◽

pp. 762-763 ◽

Cited By ~ 4

Author(s):

Melissa Cindy Kong ◽

Helen Ruth Nadel

Keyword(s):

Fdg Pet ◽

Adipose Tissues ◽

Fdg Uptake ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct ◽

Subcutaneous Adipose

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Pituitary 18F-FDG uptake correlates with serum TSH levels in thyroid cancer patients on 18F-FDG PET/CT

Nuclear Medicine Communications ◽

10.1097/mnm.0000000000000940 ◽

2019 ◽

Vol 40 (1) ◽

pp. 57-62 ◽

Cited By ~ 2

Author(s):

Yingli Ding ◽

Shuqi Wu ◽

Jing Xu ◽

Hui Wang ◽

Chao Ma

Keyword(s):

Thyroid Cancer ◽

Cancer Patients ◽

Fdg Pet ◽

Fdg Uptake ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct ◽

Serum Tsh ◽

Tsh Levels

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A case of periosteal fasciitis located in the mandible in a child

Oral Radiology ◽

10.1007/s11282-021-00544-4 ◽

2021 ◽

Author(s):

Sato Eida ◽

Yuka Hotokezaka ◽

Miho Sasaki ◽

Hitoshi Hotokezaka ◽

Shuichi Fujita ◽

...

Keyword(s):

Computed Tomography ◽

Fdg Pet ◽

Signal Intensity ◽

Fdg Uptake ◽

Pet Ct ◽

Left Mandible ◽

18F Fdg ◽

Dual Time Point ◽

Fdg Pet Ct ◽

Time Point

AbstractPeriosteal fasciitis (PF), a subtype of nodular fasciitis, is an uncommon benign soft-tissue mass that originates from the periosteum or tissues adjacent to bones. PF has rarely seen in children, especially involving in the mandible. This case report presents a rare case of PF originating from the periosteum of the mandible in an 11-year-old girl. She was referred to our hospital with fast-growing painless swelling in her left mandible. Computed tomography revealed an exophytic juxtacortical mass eroding the lower part of the left mandible and lower mandibular cortex with a periosteal reaction. The mass showed low signal intensity on T1-weighted magnetic resonance imaging (MRI) and high signal intensity on T2-weighted MRI. The apparent diffusion coefficient (ADC) of the lesion found to be moderate. Dynamic contrast-enhanced MRI revealed a gradual increment pattern in the central region of the mass. On 18F-fluorodeoxyglucose (FDG) positron-emission tomography/computed tomography (PET/CT), relatively high 18F-FDG uptake was observed on the early scan and the 18F-FDG uptake was declined on the delayed scan. The clinical and conventional radiological findings of the mass were suggestive of malignancy. However, the findings of ADC and dynamic MRI and dual-time-point FDG-PET/CT favored benign etiology over malignant etiology. Histological and immunohistochemical findings along with reactive ossification of the periosteum confirmed the diagnosis of PF. Currently, comprehensive examinations, such as clinical, imaging, and histopathological examinations, are recommended for the definitive diagnosis of PF, while MRI and dual-time-point FDG-PET/CT could have a potential usefulness to differentiate from malignancy.

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Qualitative and semiquantitative [18F]FDG-PET/CT analysis in patients with IE: a strategy to enhance specificity?

European Heart Journal ◽

10.1093/ehjci/ehaa946.0298 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

R Boni

Keyword(s):

Fdg Pet ◽

Final Diagnosis ◽

Antimicrobial Treatment ◽

Uptake Ratio ◽

Fdg Uptake ◽

Duke Criteria ◽

Focal Uptake ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

Abstract Aim The 2015 ESC Guideline for the diagnosis and management of infectious endocarditis (IE) included molecular imaging procedures such as radiolabeled leukocytes and [18F]FDG-PET/CT as major criteria to establish the diagnosis of IE. Whereas in case of radiolabeled leukocytes the criteria for defining positive and negative scan are well established, in case of [18F]FDG-PET/CT a consensus of the criteria that define a positive scan is still lacking. Materials and methods In this work we prospectively evaluated a series of 90 patients (M:F=60:30, mean age 67±16 years, median age 72 years, range 18–88) that performed [18F]FDG-PET/CT for suspected IE between January 2016 and January 2019 in our center to define which pattern of uptake and semiquantitative parameters (SUVmax, SUVmean, valve/liver, valve/lung and valve/mediastinum uptake ratio) present the highest diagnostic accuracy for IE. PET/CT results were correlated with transthoracic (TTE) or transesophageal (TEE) echocardiography, blood culture, the Duke criteria. The new ESC criteria were also evaluated. Results Globally PET/CT presented sensitivity=96% and specificity=75%, NPV= 97% and PPV=68%. A focal pattern of uptake was found 17/30 patients with confirmed IE (mean SUVmax=5.29±1.8, median SUVmax=5.5) whereas whereas a diffuse pattern of uptake was found in 11 patients with confirmed IE (mean SUVmax=8.1±3.5, median SUVmax=7.6). No significant differences between the valve/liver ratio uptake and the valve/mediastinum uptake ratio were found between positive and negative patients with either focal or diffuse pattern of uptake. Interesting, in presence of diffuse valve uptake both SUVmax and the valve/lung uptake ratio were significantly higher in patients with a final diagnosis of IE, including the group of patients under antimicrobial treatment (>90%). PET/CT confirmed its ability to identify extracardiac sites of [18F]FDG uptake in presence of septic embolism (35%) and in patients with other diseases (vasculitis, vascular prosthesis infections, mediastinitis and cancer, particularly in patients with IE sustained by Streptococcus Gallolyticus). Conclusions Our results suggest pattern of [18F]FDG uptake more specific for valve infection is a focal uptake or a diffuse uptake with a SUVmax>5 and a valve/lung ratio >8. Funding Acknowledgement Type of funding source: None

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