Characterization of hepatobiliary organic anion transporter regulation in the Zucker rat

2004 ◽  
Vol 42 (08) ◽  
Author(s):  
A Geier ◽  
CG Dietrich ◽  
C Gartung ◽  
F Lammert ◽  
HE Wasmuth ◽  
...  
Keyword(s):  
Organic Anion ◽  
Organic Anion Transporter ◽  
Zucker Rat ◽  
Anion Transporter

Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat

2005 ◽  
Vol 43 (6) ◽  
pp. 1021-1030 ◽  
Author(s):  
Andreas Geier ◽  
Christoph G. Dietrich ◽  
Tobias Grote ◽  
Ulrich Beuers ◽  
Thomas Prüfer ◽  
...  
Keyword(s):  
Organic Anion ◽  
Organic Anion Transporter ◽  
Glutathione Metabolism ◽  
Zucker Rat ◽  
Bile Formation ◽  
Anion Transporter ◽  
Obese Zucker Rat

Characterization of the Uptake of Organic Anion Transporter (OAT) 1 and OAT3 Substrates by Human Kidney Slices

2007 ◽  
Vol 321 (1) ◽  
pp. 362-369 ◽  
Author(s):  
Yoshitane Nozaki ◽  
Hiroyuki Kusuhara ◽  
Tsunenori Kondo ◽  
Maki Hasegawa ◽  
Yoshiyuki Shiroyanagi ◽  
...  
Keyword(s):  
Organic Anion ◽  
Human Kidney ◽  
Organic Anion Transporter ◽  
Kidney Slices ◽  
Anion Transporter

Molecular Characterization of the Renal Organic Anion Transporter 1

2002 ◽  
Vol 36 (2-3) ◽  
pp. 169-174 ◽  
Author(s):  
Gerhard Burckhardt ◽  
Natascha A Wolff ◽  
Andrew Bahn
Keyword(s):  
Molecular Characterization ◽  
Organic Anion ◽  
Organic Anion Transporter ◽  
Anion Transporter

scholarly journals Cloning and Functional Characterization of Human Sodium-dependent Organic Anion Transporter (SLC10A6)

2007 ◽  
Vol 282 (27) ◽  
pp. 19728-19741 ◽  
Author(s):  
Joachim Geyer ◽  
Barbara Döring ◽  
Kerstin Meerkamp ◽  
Bernhard Ugele ◽  
Nadiya Bakhiya ◽  
...  
Keyword(s):  
Organic Anion ◽  
Functional Characterization ◽  
Organic Anion Transporter ◽  
Anion Transporter ◽  
Sodium Dependent

Characterization of mouse organic anion transporter 5 as a renal steroid sulfate transporter

2005 ◽  
Vol 97 (4) ◽  
pp. 369-375 ◽  
Author(s):  
Jin-Oh Kwak ◽  
Hyun-Woo Kim ◽  
Kwang-Jin Oh ◽  
Chang-Bo Ko ◽  
Hwayong Park ◽  
...  
Keyword(s):  
Organic Anion ◽  
Organic Anion Transporter ◽  
Sulfate Transporter ◽  
Anion Transporter ◽  
Steroid Sulfate

scholarly journals Genetic variants of human organic anion transporter 4 demonstrate altered transport of endogenous substrates

2010 ◽  
Vol 299 (4) ◽  
pp. F767-F775 ◽  
Author(s):  
James E. Shima ◽  
Takafumi Komori ◽  
Travis R. Taylor ◽  
Doug Stryke ◽  
Michiko Kawamoto ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Drug Disposition ◽  
Organic Anion ◽  
Functional Characterization ◽  
Organic Anion Transporter ◽  
Loss Of Function ◽  
Anion Transporter ◽  
Endogenous Substrates ◽  
Slc Transporter

Apical reabsorption from the urine has been shown to be important for such processes as the maintenance of critical metabolites in the blood and the excretion of nephrotoxic compounds. The solute carrier (SLC) transporter OAT4 ( SLC22A11) is expressed on the apical membrane of renal proximal tubule cells and is known to mediate the transport of a variety of xenobiotic and endogenous organic anions. Functional characterization of genetic variants of apical transporters thought to mediate reabsorption, such as OAT4, may provide insight into the genetic factors influencing the complex pathways involved in drug elimination and metabolite reclamation occurring in the kidney. Naturally occurring genetic variants of OAT4 were identified in public databases and by resequencing DNA samples from 272 individuals comprising 4 distinct ethnic groups. Nine total nonsynonymous variants were identified and functionally assessed using uptake of three radiolabeled substrates. A nonsense variant, R48Stop, and three other variants (R121C, V155G, and V155M) were found at frequencies of at least 2% in an ethnic group specific fashion. The L29P, R48Stop, and H469R variants displayed a complete loss of function, and kinetic analysis identified a reduced Vmax in the common nonsynonymous variants. Plasma membrane levels of OAT4 protein were absent or reduced in the nonfunctional variants, providing a mechanistic reason for the observed loss of function. Characterization of the genetic variants of reabsorptive transporters such as OAT4 is an important step in understanding variability in tubular reabsorption with important implications in innate homeostatic processes and drug disposition.

Identification and Characterization of Human Organic Anion Transporter 3 Expressing Predominantly in the Kidney

2001 ◽  
Vol 59 (5) ◽  
pp. 1277-1286 ◽  
Author(s):  
Seok Ho Cha ◽  
Takashi Sekine ◽  
Jun-ichi Fukushima ◽  
Yoshikatsu Kanai ◽  
Yukari Kobayashi ◽  
...  
Keyword(s):  
Organic Anion ◽  
Organic Anion Transporter ◽  
Anion Transporter ◽  
Organic Anion Transporter 3 ◽  
Identification And Characterization
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