Artificial Liver Support–Dosefinding Studies and In Vitro Comparison of Single Pass Albumin Dialysis (SPAD) with MARS and CVVHDF

2005 ◽  
Vol 43 (05) ◽  
Author(s):  
IM Sauer ◽  
M Goetz ◽  
G Walter ◽  
I Steffen ◽  
U Stumborg ◽  
...  
Keyword(s):  
Artificial Liver ◽  
Albumin Dialysis ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Single Pass ◽  
In Vitro Comparison

Studies of Adsorbents for Hemoperfusion in Artificial Liver Support. I. Preparation and in Vitro Studies of Cross-Linked Agarose Beads Entrapped Activated Charcoal (CAAC)

1981 ◽  
Vol 4 (4) ◽  
pp. 200-204 ◽  
Author(s):  
C.X. Xu ◽  
X.J. Tang ◽  
Z. Niu ◽  
Z.M. Li
Keyword(s):  
Thermal Stability ◽  
Blood Flow ◽  
High Temperature ◽  
Mechanical Strength ◽  
Activated Charcoal ◽  
Artificial Liver ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Agarose Beads

A new method for the preparation of the cross-linked agarose beads entrapped activated charcoal (CAAC) is reported. Since the agarose-encapsulated adsorbents reported elsewhere cannot stand high temperature for sterilization, the CAAC has the advantage of thermal stability to withstand autoclave at 121°C. for ½ hour without breaking up or melting. A further advantage of CAAC is that the adsorbent has a much better consistency with good mechanical strength and elasticity, so that it can be formed into beads of a diameter less than 1 mm. This will not only give a better adsorption capacity than larger beads, but can also assure a better blood flow than soft beads which usually interfere in hemoperfusion due to compacting and sludging. Preliminary investigations indicate that the CAAC is relatively hemocompatible.

Comparative Evaluation of Different Membranes for the Construction of an Artificial Liver Support System

1997 ◽  
Vol 20 (2) ◽  
pp. 119-124 ◽  
Author(s):  
S. Qiang ◽  
Y. Yaoting ◽  
L. Hongyin ◽  
H. Klinkmann
Keyword(s):  
Hepatoma Cell ◽  
Hepatoma Cell Line ◽  
Artificial Liver ◽  
Human Hepatoma Cell ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Liver Support System ◽  
Extracorporeal Liver Support ◽  
Hepatocyte Growth

During the past decades, many technological improvements have been made in the construction of extracorporeal liver support systems. Among these achievements, membranes of artificial capillary system, used as substrates of hepatocyte growth, aroused our interest in their application for the construction of bioreactors. The present paper studied the comparison of hepatocyte growth and function on six different membranes. Four of them are cellulose based membranes, Cuprophan, Hemophan, Cellulose acetate, and Bioflux; two are synthetic polymer SPAN and Polysulphone. Human hepatoma cell line SMMC-7721, with moderately differentiated hepatocyte-specific functions, was inoculated into the hollow fiber cartridges. These cells were allowed to attach and to grow over these membranes. It was found that there existed differences in hepatocyte immobilization and growth among these membranes. They influenced the growth and functions of hepatoma cells in vitro to some extent. These results show that membrane is an important factor in the construction of capillary membrane bioreactors for artificial liver support.

Albumin Dialysis With a Noncell Artificial Liver Support Device in Patients With Acute Liver Failure

2013 ◽  
Vol 159 (8) ◽  
pp. 522 ◽  
Author(s):  
Faouzi Saliba ◽  
Christophe Camus ◽  
François Durand ◽  
Philippe Mathurin ◽  
Alexia Letierce ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Artificial Liver ◽  
Albumin Dialysis ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Support Device

Albumin Apheresis for Artificial Liver Support: In Vitro Testing of a Novel Filter

2018 ◽  
Vol 22 (4) ◽  
pp. 399-409
Author(s):  
Tomasz Piatek ◽  
Joanna Giebultowicz ◽  
Marieke Rüth ◽  
Horst-Dieter Lemke ◽  
Florian Bonn ◽  
...  
Keyword(s):  
In Vitro Testing ◽  
Artificial Liver ◽  
Liver Support ◽  
Artificial Liver Support

scholarly journals In vitro comparison of the molecular adsorbent recirculation system (MARS) and single-pass albumin dialysis (SPAD)

Hepatology ◽  
2004 ◽  
Vol 39 (5) ◽  
pp. 1408-1414 ◽  
Author(s):  
Igor M. Sauer ◽  
Max Goetz ◽  
Ingo Steffen ◽  
Gesa Walter ◽  
Daniel C. Kehr ◽  
...  
Keyword(s):  
Albumin Dialysis ◽  
Single Pass ◽  
Recirculation System ◽  
Molecular Adsorbent ◽  
In Vitro Comparison

The Comparison of Albumin Dialysis between Open- and Closed-Loop Dialysis Modes

2014 ◽  
Vol 960-961 ◽  
pp. 47-51
Author(s):  
Ying Ying Pei ◽  
Yi Ze Sun ◽  
Si Jie Sun ◽  
Da Yong Gao ◽  
Wei Ping Ding
Keyword(s):  
Closed Loop ◽  
Support Systems ◽  
Open Loop ◽  
Molar Ratio ◽  
Artificial Liver ◽  
Albumin Dialysis ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Physical Size ◽  
Overall Performance

The open-loop albumin dialysis mode (OLM) is usually used to remove protein-bound toxins from artificial liver support systems. However, there is still interest in closed-loop albumin dialysis mode (CLM) because this mode could enable the regeneration and reuse of albumin and minimize the physical size of liver support systems. In this paper, the two dialysis modes were theoretically compared under various theoretical conditions. Our results show that at the beginning of the dialysis period, in terms of detoxification efficiency, CLM is better. As the molar ratio of toxin to albumin in the blood (RTA) decreases, the overall performance of CLM approaches that of OLM in 4-hour dialysis. In certain cases, the clearance of albumin-bound toxins by CLM could be as effective as that by OLM; occasionally, CLM is even more effective.

scholarly journals IMPACT OF ARTIFICIAL LIVER SUPPORT WITH ALBUMIN DIALYSIS (MARS) ON LABORATORY FINDINGS

ASAIO Journal ◽  
2000 ◽  
Vol 46 (2) ◽  
pp. 242
Author(s):  
S. Klammt ◽  
S. Mitzner ◽  
J. Stange ◽  
B. Brinkmann ◽  
P. Peszynski ◽  
...  
Keyword(s):  
Artificial Liver ◽  
Albumin Dialysis ◽  
Liver Support ◽  
Laboratory Findings ◽  
Artificial Liver Support
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