Obstructive sleep apnea - an underestimated cardiovascular risk factor

2005 ◽  
Vol 130 (49) ◽  
pp. 2817-2817
Author(s):  
B Sanner
Keyword(s):  
Obstructive Sleep Apnea ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Sleep Apnea ◽  
Cardiovascular Risk Factor ◽  
Obstructive Sleep

scholarly journals OBSTRUCTIVE SLEEP APNEA SYNDROME AS CARDIOVASCULAR RISK FACTOR ASSOCIATED WITH HYPERURICEMIA

2021 ◽  
Vol 39 (Supplement 1) ◽  
pp. e397-e398
Author(s):  
Ruth Skvortsova ◽  
Kristina Anisimova ◽  
Viktoria Pavlova ◽  
Anna Obukhova ◽  
Kristina Popova ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Cardiovascular Risk Factor ◽  
Sleep Apnea Syndrome ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Abstract 2174: Increased Platelet Aggregability In Obstructive Sleep Apnea Syndrome Patients Is Improved By Nasal Continuous Positive Airway Pressure Treatment

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Hisanori Horiuchi ◽  
Kensuke Sumi ◽  
Arata Tabuchi ◽  
Ryoji Taniguchi ◽  
Toru Oga ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Platelet Aggregation ◽  
Sleep Apnea ◽  
Platelet Aggregability ◽  
Nasal Cpap ◽  
Obstructive Sleep ◽  
Significant Difference ◽  
Induced Aggregation

Background and aim: Obstructive sleep apnea (OSA) is a risk factor for cerebrovascular diseases. One cause for them is an occlusive arterial thrombus triggered by local platelet activation. Whether OSA is an independent risk factor for increased platelet aggregability is unclear. Methods: We enrolled 124 patients with snoring or daytime sleepiness in whom 3% oxygen desaturation index (3%ODI), a principal marker of the severity of intermittent hypoxia and reoxygenation (IHR), was measured. We studied ex vivo ADP- and collagen-induced aggregation of platelet-rich plasma using an optical aggregometer. The agonist concentration giving half maximal aggregation was defined as the platelet-aggregation threshold index (PATI) value. Therefore, the lower PATI value implicates the higher aggregability. In 23 patients who underwent nasal CPAP, platelet aggregability was followed until 90 days. Results: There was a significant difference in the PATI value for ADP-induced aggregation between 66 patients with non-to-mild OSA (3%ODI≤15) (1.04±0.07 μM, mean±SE) and 58 patients with moderate-to-severe OSA(3%ODI>15) (0.78±0.09 μM)(p=0.029). Multiple linear model revealed that 3%ODI strongly significantly contributed to the PATI values for ADP (p<0.001) and collagen (p=0.0026) among the 59 subjects with a cardiovascular risk factor such as smoking, hypertension, diabetes mellitus or hyperlipidemia. However, the percentage of time of arterial O2 saturation<90% during sleep did not significantly contribute to the PATI values for ADP (p=0.21) and collagen (p=0.20). After initiation of nasal CPAP therapy, the PATI values for ADP-induced aggregation significantly worsened transiently on day 30 (p=0.035), and then it recovered and improved at day 90 and the PATI for collagen-induced aggregation improved at day 90 without the transient exacerbation. Conclusions: OSA patients had increased platelet aggregability. Severity of IHR more significantly contributed to platelet aggregation than total hypoxic time. Among OSA patients with conventional cardiovascular risk factors, the effects of IHR on the platelet aggregability was prominent. Nasal CPAP initially induced a transient hyperaggregable state of platelets, after which it continued to improve.

scholarly journals Obstructive Sleep Apnea as a Risk Factor of Insulin Resistance in Nondiabetic Adults

Life ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 50
Author(s):  
Monika Michalek-Zrabkowska ◽  
Piotr Macek ◽  
Helena Martynowicz ◽  
Pawel Gac ◽  
Grzegorz Mazur ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Obstructive Sleep Apnea ◽  
Risk Factor ◽  
Sleep Apnea ◽  
Glucose Concentration ◽  
Insulin Concentration ◽  
Fasting Insulin ◽  
Sleep Habits ◽  
Obstructive Sleep

Objective: The aim of this research was to assess the relationship between prevalence and severity of obstructive sleep apnea (OSA) and insulin resistance among patients with increased risk of OSA without diabetes mellitus. Method and materials: our study group involved 102 individuals with suspected OSA, mean age 53.02 ± 12.37 years. Data on medical history, medication usage, sleep habits, sleep quality and daytime sleepiness, were obtained using questionnaires. All patients underwent standardized full night polysomnography. Serum fasting insulin and glucose concentration were analyzed, the homeostatic model assessment-insulin resistance (HOMA-IR) index was calculated. Results: polysomnographic study indicated that in the group with OSA mean values of apnea–hypopnea index (AHI), oxygen desaturation index (ODI), duration of SpO2 < 90% and average desaturation drop were significantly higher compared to the group without OSA, while the minimum SpO2 was significantly lower. The carbohydrate metabolism parameters did not differ within those groups. Significantly higher fasting insulin concentration and HOMA-IR index were found in the group with AHI ≥ 15 compared to the group with AHI < 15 and in the group with AHI ≥ 30 compared to the group with AHI < 30. Higher AHI and ODI were independent risk factors for higher fasting insulin concentration and higher HOMA-IR index. Increased duration of SpO2 < 90% was an independent risk factor for higher fasting glucose concentration. Conclusions: Individuals with moderate to severe OSA without diabetes mellitus had a higher prevalence of insulin resistance.

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