OBSTRUCTIVE SLEEP APNEA SYNDROME AS CARDIOVASCULAR RISK FACTOR ASSOCIATED WITH HYPERURICEMIA

Recently, it has been clearly described an independent relationship between obstructive sleep apnea syndrome (OSAS) and cardiovascular risk, with underlying mechanisms also including endothelial dysfunction. We enrolled 32 consecutive non-obese patients (mean age of 39.5±11.5 years), of which 16 with mild OSAS and 16 snoring without OSAS. Mild OSAS is defined by an AHI index between 5 and 15. We have investigated if whether there was a relationship between mild OSAS, endothelial function and carotid intima-media thickness (C-IMT). The population was divided into two groups: Group 1 (16 simple snorer patients with an average age of 39.4±12.1 years) and Group 2 (16 subjects with mild OSAS with an average age of 39.6±11.2 years). Each group underwent cardiovascular investigation including measurement of flow-mediated dilation (FMD) of the brachial artery and C-IMT. Both groups comprised non-obese subjects. Patients with mild OSAS had serum total cholesterol values statistically significantly higher than simple snores patients (178.6±24.9 vs 159.2±25.3; p=0.038). OSAS patients had also a trend towards higher values of maximum C-IMT compared to simple snorer patients (0.70±0.15 vs 0.65±0.16), although below the level of significance. Between the two groups, no difference was found for FMD values. The present results on mild OSAS strengthen the importance of a diagnosis of OSAS as soon as possible, in order to encourage all primary prevention interventions to correct risk factors responsible for disease progression and the occurrence of cardiovascular diseases, not excluding the use of therapies of non-invasive ventilation even in the early stages of the disease.

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Sex-Related Differences in Polygraphic Parameters in a Population of Patients with Obstructive Sleep Apnea Syndrome

CNS & Neurological Disorders - Drug Targets ◽

10.2174/1871527320666211022104140 ◽

2021 ◽

Vol 20 ◽

Author(s):

Laura Buratti ◽

Chiara Rocchi ◽

Viviana Totaro ◽

Serena Broggi ◽

Simona Lattanzi ◽

...

Keyword(s):

Obstructive Sleep Apnea ◽

Cardiovascular Risk ◽

Sleep Apnea ◽

Sleep Quality ◽

Obstructive Sleep Apnea Syndrome ◽

Sleep Apnea Syndrome ◽

Men And Women ◽

Autonomic Changes ◽

Obstructive Sleep ◽

Apnea Syndrome

Background: Sex-related differences in the prevalence and clinical presentation of Obstructive Sleep Apnea Syndrome (OSAS) have been widely documented. The aim of this study was to investigate the influence of patients’ sex on polygraphic parameters with particular attention to sleep autonomic changes in a population of OSAS patients. Methods: Sixty OSAS patients aged 55-65 years (30 men, 30 women) were enrolled. Sleep quality was assessed with the Pittsburgh Sleep Quality Index (PSQI) and daytime sleepiness with the Epworth Sleepiness Scale (ESS). The presence of respiratory events and autonomic changes during the night was investigated by polygraphy. Results : Similar main cardiovascular risk factors prevalence was observed in both men and women. We observed a significant difference in PSQI (higher in women, p=0.0001) and ESS (higher in men, p=0.004) scores. Snoring (p=0.033), supine AHI (p=0.004), T90 (p=0.021), LO2 (p=0.0001), LF/HF ratio and LF (p=0.0001) were significantly higher in men. Sex differences in PSQI mean score and LF/HF ratio variability were preserved in all the subgroups of OSA severity. Conclusion: The influence of sex in modulating cardiovascular risk is a widely discussed topic. In our study, men showed more severe polygraphic parameters and an increase in LF/HF ratio compared to women. The results of our investigation suggest the relevance of delivering information about the different expressions of OSAS in men and women in order to improve diagnostic skills and in-depth prevention approaches.

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Is It Time to Consider Obstructive Sleep Apnea Syndrome a Risk Factor for Alzheimer’s Disease?

American Journal of Respiratory and Critical Care Medicine ◽

10.1164/rccm.201710-2105ed ◽

2018 ◽

Vol 197 (7) ◽

pp. 855-856 ◽

Cited By ~ 4

Author(s):

Claudio Liguori ◽

Fabio Placidi

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Obstructive Sleep Apnea ◽

Risk Factor ◽

Sleep Apnea ◽

Obstructive Sleep Apnea Syndrome ◽

Sleep Apnea Syndrome ◽

Obstructive Sleep ◽

Apnea Syndrome

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SERUM OSMOLARITY IS ASSOCIATED WITH SEVERITY OF OBSTRUCTIVE SLEEP APNEA SYNDROME: A NOVEL RISK FACTOR FOR CARDIOVASCULAR DISEASE

10.1183/13993003.congress-2018.pa413 ◽

2018 ◽

Author(s):

Asiye Kanbay ◽

Mustafa Çalışkan ◽

Halil İbrahim Yakar ◽

Sebahat Alışır Ecder

Keyword(s):

Cardiovascular Disease ◽

Obstructive Sleep Apnea ◽

Risk Factor ◽

Sleep Apnea ◽

Obstructive Sleep Apnea Syndrome ◽

Sleep Apnea Syndrome ◽

Serum Osmolarity ◽

Obstructive Sleep ◽

Apnea Syndrome

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Aortic Pressure Augmentation as a Marker of Cardiovascular Risk in Obstructive Sleep Apnea Syndrome

Hypertension Research ◽

10.1291/hypres.31.1109 ◽

2008 ◽

Vol 31 (6) ◽

pp. 1109-1114 ◽

Cited By ~ 16

Author(s):

Akiko NODA ◽

Seiichi NAKATA ◽

Hiroshi FUKATSU ◽

Yoshinari YASUDA ◽

Etsuko MIYAO ◽

...

Keyword(s):

Obstructive Sleep Apnea ◽

Cardiovascular Risk ◽

Sleep Apnea ◽

Obstructive Sleep Apnea Syndrome ◽

Sleep Apnea Syndrome ◽

Aortic Pressure ◽

Obstructive Sleep ◽

Apnea Syndrome

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Obstructive sleep apnea syndrome is a risk factor for arterial hypertension

Arterial’naya Gipertenziya (Arterial Hypertension) ◽

10.18705/1607-419x-2003-9-2-37-41 ◽

2003 ◽

Vol 9 (2) ◽

pp. 37-41

Author(s):

A. L. Kalinkin

Keyword(s):

Obstructive Sleep Apnea ◽

Risk Factor ◽

Sleep Apnea ◽

Cardiovascular Diseases ◽

Arterial Hypertension ◽

Obstructive Sleep Apnea Syndrome ◽

Sleep Apnea Syndrome ◽

Experimental Studies ◽

Obstructive Sleep ◽

Apnea Syndrome

The obstructive sleep apnea syndrome (OSAS) is a risk factor for cardiovascular diseases The results of epidemiological, observational, and experimental studies support the fact that OSAS is of considerable importance in the development of arterial hypertension via chronic sympathetic activation and sleep-induced neurohumoral changes OSAS is of prime importance in the development of refractory AH CPAP therapy not only eliminates sleep-induced obstructive respiratory impairments, but frequently lowers blood pressure in hypertensive patients, and improves the prognosis of cardiovascular diseases

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Comparison of the Effects of the Somatotype on the Physical Activity, Kinesiophobia, and Fatigue Levels of Obstructive Sleep Apnea Syndrome Patients and Healthy Individuals

Iranian Journal of Public Health ◽

10.18502/ijph.v50i5.6109 ◽

2021 ◽

Author(s):

Şeyma Toy ◽

Rukiye Çiftçi ◽

Deniz Şenol ◽

Fatma Kizilay ◽

Hilal Ermiş

Keyword(s):

Physical Activity ◽

Obstructive Sleep Apnea ◽

Risk Factor ◽

Sleep Apnea ◽

Obstructive Sleep Apnea Syndrome ◽

Sleep Apnea Syndrome ◽

Activity Level ◽

Healthy Individuals ◽

Obstructive Sleep ◽

Apnea Syndrome

Background: We aimed to compare the physical activity, kinesiophobia, and fatigue levels of obstructive sleep apnea syndrome (OSAS) patients and healthy individuals in terms their somatotypes. Methods: A total of 165 individuals were enrolled referred to the Department of Chest Diseases Sleep Disorders Center Outpatient Clinic of Inonu University, Malatya, Turkey in 2018. The somatotype analysis was conducted using the Heath-Carter method, the fatigue level was assessed using the Functional Assessment of Chronic Illness Therapy (FACIT) fatigue scale, the kinesiophobia level was assessed using the Tampa Scale for Kinesiophobia (TSK), and the physical activity level was assessed using the International Physical Activity Questionnaire (IPAQ). Results: The results of the somatotype analysis revealed 3 different somatotypes in the healthy individuals and the OSAS patients’ mesomorph endomorph, endomorphic mesomorph, and mesomorphic endomorph. When comparing the somatotypes of the healthy individuals and the OSAS patients, statistically significant differences were found in the FACIT scores of the mesomorph endomorphs, the IPAQ and FACIT scores of the endomorphic mesomorphs, and the TSK and FACIT scores of the mesomorphic endomorphs (P<0.05). Conclusion: In all three somatotypes of the OSAS patients, the fatigue index scores were higher when compared to those of the healthy individuals. Moreover, when compared with the healthy individuals, the physical activity levels of the endomorphic mesomorphs with OSAS were low, while the kinesiophobia scores of the mesomorphic endomorphs with OSAS were high. Based on the results of this study, in OSAS patients, the endomorphic mesomorph somatotype could be a risk factor for reduced physical activity, while the mesomorphic endomorph somatotype could be a risk factor for increased kinesiophobia.

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