Metal-Free Carbon—Carbon Bond-Forming Processes

2012 ◽  
pp. 1
Author(s):  
A. Chanda ◽  
V. V. Fokin
Keyword(s):  
Free Carbon ◽  
Carbon Bond ◽  
Metal Free ◽  
Bond Forming ◽  
Carbon Carbon Bond

Metal-free carbon–carbon bond-forming reductive coupling between boronic acids and tosylhydrazones

2009 ◽  
Vol 1 (6) ◽  
pp. 494-499 ◽  
Author(s):  
José Barluenga ◽  
María Tomás-Gamasa ◽  
Fernando Aznar ◽  
Carlos Valdés
Keyword(s):  
Boronic Acids ◽  
Free Carbon ◽  
Reductive Coupling ◽  
Carbon Bond ◽  
Metal Free ◽  
Bond Forming ◽  
Carbon Carbon Bond

Nickel-Catalyzed Electronically-Reversed Enantioselective Hydrocarbofunctionalizations of Acrylamides

Synlett ◽  
2021 ◽  
Author(s):  
Lou Shi ◽  
Wei Shu
Keyword(s):  
Nickel Catalyst ◽  
Functional Group ◽  
Optically Active ◽  
Forming Process ◽  
Carbon Bond ◽  
Bond Forming ◽  
Synthetic Strategy ◽  
Carbon Carbon Bond ◽  
Wide Range ◽  
Simple Protocol

Asymmetric hydrocarbofunctionalizations of alkenes has emerged as an efficient synthetic strategy for accessing optically active molecules via carbon-carbon bond-forming process from readily available alkenes and carbo-electrophiles. Herein, we present a summary of the efforts from our group to control the regio- and enantioselectivity of hydrocarbofunctionalizations of electron-deficient alkenes with a nickel catalyst and chiral bisoxazolidine ligand. The reaction undergoes electron-reversed hydrocarbofunctionalizations acrylamides with excellent enantioselectivity. This operationally simple protocol enables the asymmetric hydroalkylation, hydrobenzylation and hydropropargylation of acrylamides. This reaction is useful for preparing a wide range of α-branched chiral amides with broad functional group tolerance.

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