Age, Renal Tubular Phosphate Reabsorption, and Serum Phosphate Levels in Adults

2008 ◽  
Vol 359 (8) ◽  
pp. 864-866 ◽  
Author(s):  
Massimo Cirillo ◽  
Carolina Ciacci ◽  
Natale G. De Santo
1978 ◽  
Vol 234 (1) ◽  
pp. F22-F28 ◽  
Author(s):  
S. Goldfarb ◽  
M. Bosanac ◽  
M. Goldberg ◽  
Z. S. Agus

2012 ◽  
Vol 36 (1) ◽  
pp. 149-161 ◽  
Author(s):  
Ganesh Pathar ◽  
Michael Föller ◽  
Arezoo Daryadel ◽  
Kerim Mutig ◽  
Evgeny Bogatikov ◽  
...  

1985 ◽  
Vol 249 (2) ◽  
pp. F315-F318
Author(s):  
T. G. Hammond ◽  
A. Haramati ◽  
F. G. Knox

Atrial natriuretic factor (ANF), a family of peptides isolated from cardiac atria, has marked effects on sodium excretion. A synthetic 26 amino acid sequence of ANF peptide has also been shown to be phosphaturic. However, it is difficult to assess whether the phosphaturia is due to changes in tubular reabsorption of phosphate without control of filtered load of phosphate. In the present study, the hypothesis that ANF peptide decreases tubular phosphate reabsorption was tested by using graded phosphate infusions of 0, 1, 2, and 3 mumol/min in thyroparathyroidectomized rats. Further, reabsorbed phosphate was similarly assessed in rats infused with parathyroid hormone (PTH) to allow comparison with a known phosphaturic hormone. ANF peptide decreased reabsorbed phosphate compared with saline controls (2.72 +/- 0.28 mumol/ml GFR compared with 3.35 +/- 0.35, P less than 0.05) but not as much as a maximally phosphaturic dose of PTH (2.04 +/- 0.13 mumol/ml GFR). We conclude that synthetic ANF peptide decreases tubular phosphate reabsorption in vivo.


1964 ◽  
Vol 207 (1) ◽  
pp. 89-96 ◽  
Author(s):  
Dorothea Hellman ◽  
H. Robert Baird ◽  
Frederic C. Bartter

A maximal renal tubular rate of reabsorption of phosphate (Tmp) has been demonstrated in the normal dog. In the dog, as in the man, considerable variability in the Tmp often occurs. While some of this variability remains unexplained, a direct relationship between glomerular filtration rate (GFR) and Tmp can be demonstrated when the GFR is varied over a wide range. This relationship suggests that glomerular intermittency may exist in the dog.


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