Determination of Discharge Distribution in Meandering Compound Channels Using Machine Learning Techniques

Author(s):  
Abinash Mohanta ◽  
Arpan Pradhan ◽  
K. C. Patra
2020 ◽  
Vol 16 (4) ◽  
pp. 407-419
Author(s):  
Aytun Onay ◽  
Melih Onay

Background: Virtual screening of candidate drug molecules using machine learning techniques plays a key role in pharmaceutical industry to design and discovery of new drugs. Computational classification methods can determine drug types according to the disease groups and distinguish approved drugs from withdrawn ones. Introduction: Classification models developed in this study can be used as a simple filter in drug modelling to eliminate potentially inappropriate molecules in the early stages. In this work, we developed a Drug Decision Support System (DDSS) to classify each drug candidate molecule as potentially drug or non-drug and to predict its disease group. Methods: Molecular descriptors were identified for the determination of a number of rules in drug molecules. They were derived using ADRIANA.Code program and Lipinski's rule of five. We used Artificial Neural Network (ANN) to classify drug molecules correctly according to the types of diseases. Closed frequent molecular structures in the form of subgraph fragments were also obtained with Gaston algorithm included in ParMol Package to find common molecular fragments for withdrawn drugs. Results: We observed that TPSA, XlogP Natoms, HDon_O and TPSA are the most distinctive features in the pool of the molecular descriptors and evaluated the performances of classifiers on all datasets and found that classification accuracies are very high on all the datasets. Neural network models achieved 84.6% and 83.3% accuracies on test sets including cardiac therapy, anti-epileptics and anti-parkinson drugs with approved and withdrawn drugs for drug classification problems. Conclusion: The experimental evaluation shows that the system is promising at determination of potential drug molecules to classify drug molecules correctly according to the types of diseases.


Author(s):  
Sergio Arce-García ◽  
Natalia Orviz-Martínez ◽  
Tatiana Cuervo-Carabel

The use of Twitter by newspapers is widespread and is a way to keep readers informed in real time. In this article, we analyze the discourse of the messages released by the ten main general information newspapers in Spain and the reactions they provoked on the social network. The objective is to analyze whether the emotional discourse of the news in each newspaper caused greater dissemination among and attention from users, as well as to determine the emotions and feelings expressed by them. To do so, news about important events such as court judgements, street riots, and general elections was followed between October and November 2019. A total of 124,897 tweets collected using machine-learning techniques were analyzed by the application of algorithms which allowed the determination of emotions and valences of feelings. We carried out statistical studies and produced graphs showing the dependence between emotional variables and positive or negative sentimental valence. The results showed that, in general, newspapers do not use an excessive amount of emotional speech with the aim of impacting their public. However, differences were found among the newspapers in terms of trying to encourage reader loyalty. The reaction of the users was more linked to the informative facts themselves and the emotions they provoked than to the type of emotional and/or polarized discourse. The day-to-day information determines to a large extent what is consumed by Twitter users, in which changing modes of speech are observed depending on the editorial line of each newspaper. Resumen El uso de Twitter por parte de los diarios de información está muy extendido y es una forma de tener a sus lectores informados casi en tiempo real. En este artículo analizamos el discurso de los mensajes vertidos por los diez principales diarios de información general en España y las reacciones que provocan en la red social. El objetivo de esta investigación es analizar si es el discurso emocional de las noticias de cada diario el que provoca mayor difusión y atención por parte de los usuarios, así como conocer las emociones y sentimientos vertidos temporalmente en los mismos. Para ello se hizo un seguimiento entre octubre y noviembre de 2019 de noticias que incluyen acontecimientos importantes como sentencias, altercados o la celebración de elecciones generales. Mediante el empleo de técnicas de machine learning se analizaron con la aplicación de algoritmos 124.897 tweets, lo que permitió determinar las emociones y valencias, así como desarrollar estudios estadísticos y gráficos de dependencia entre variables emocionales y de valencia sentimental positiva o negativa. Los resultados evidencian que en general, no se emplean excesivos discursos emocionales que busquen impactar. Sin embargo, sí que se aprecian diferencias de uso emocional y de sentimientos entre los diarios que pretenden la fidelización del lector. Por contra se encuentra que la reacción de los usuarios está más ligada al hecho informativo en sí y a las emociones que les provocan, que al tipo de discurso emocional y/o polarizado. El día a día informativo determina en gran medida qué se consume por parte de los usuarios de la red social, en la que se aprecian discursos cambiantes en función de la línea editorial de cada diario.


2015 ◽  
Vol 61 ◽  
pp. 395-401 ◽  
Author(s):  
Nijat Mehdiyev ◽  
Julian Krumeich ◽  
David Enke ◽  
Dirk Werth ◽  
Peter Loos

2012 ◽  
Vol 59 (4) ◽  
pp. 1155-1161 ◽  
Author(s):  
Myriam Cilla ◽  
Javier Martinez ◽  
Estefania Pena ◽  
Miguel Angel Martinez

Author(s):  
Andrei Popescu ◽  
Seda Polat-Erdeniz ◽  
Alexander Felfernig ◽  
Mathias Uta ◽  
Müslüm Atas ◽  
...  

AbstractConstraint solving is applied in different application contexts. Examples thereof are the configuration of complex products and services, the determination of production schedules, and the determination of recommendations in online sales scenarios. Constraint solvers apply, for example, search heuristics to assure adequate runtime performance and prediction quality. Several approaches have already been developed showing that machine learning (ML) can be used to optimize search processes in constraint solving. In this article, we provide an overview of the state of the art in applying ML approaches to constraint solving problems including constraint satisfaction, SAT solving, answer set programming (ASP) and applications thereof such as configuration, constraint-based recommendation, and model-based diagnosis. We compare and discuss the advantages and disadvantages of these approaches and point out relevant directions for future work.


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