Characterization of small, Type V edge-localized modes in the National Spherical Torus Experiment

The design and R&D for ITER In-Vessel Coils (IVCs) is being deployed. The concerned issue of “Edge Localized Modes” (ELMs) and “Vertical Stabilization” (VS) of the ITER plasma can be addressed by the implemented IVCs. The ELM and VS coils will be installed in the vessel just behind the blanket shield modules to reach the requirement of keeping strong coupling with the plasma. The 59mm Stainless Steel Jacketed Mineral Insulated Conductor (SSMIC) using MgO as the insulation is being designed for the IVCs to resist the special challenges, including the nuclear radiation, high temperature, electromagnetic and thermal fatigue. It is necessary to take the mechanical performances of the SSMIC and the feasibility of fabrication techniques into consideration of the R&D program. The mechanical performances of the SSMIC close to the actual work conditions, including the three point bend modulus, three point bend cyclical performance and the cyclical performance with a U-bend sample of the SSMIC prototypes have been investigated and the results are presented in this paper.

Download Full-text

Dietary fat clearance in type V hyperlipoproteinaemia secondary to a rare variant of human apolipoprotein E: the apolipoprotein E3 (Arg 136 → Ser)

British Journal Of Nutrition ◽

10.1017/s0007114500000787 ◽

2000 ◽

Vol 83 (6) ◽

pp. 615-622 ◽

Cited By ~ 6

Author(s):

Bernard Vialettes ◽

Pascal Reynier ◽

Catherine Atlan-Gepner ◽

Nadia Mekki ◽

Laurence Lesluyes-Mazzochi ◽

...

Keyword(s):

Phenotypic Expression ◽

Present Case Report ◽

Human Apolipoprotein ◽

Low Fat Diet ◽

Mutant Variant ◽

Restriction Polymorphism ◽

Polymerase Chain ◽

Type V ◽

Selection Of

This present case report describes two siblings with severe type V hyperlipoproteinaemia, diagnosed very early in life and due to the combination of the common apolipoprotein (Apo) E2 allele and a rare mutant variant of ApoE, ApoE3 (Arg 136 → Ser). Phenotyping of ApoE falsely identified E2/E2 phenotype. The presence of mutated ApoE was suspected on an unusual restriction polymorphism of a Hha 1 restriction site and confirmed by sequence analysis of the cloned polymerase chain reaction fragment of exon 4 and familial segregation study. The severity of the hypertriacylglycerolaemia was modulated by the lipid content of the diet. A low-fat diet enriched in medium-chain triacylglycerol (TAG) decreased but did not normalize plasma TAG levels in both affected patients of the pedigree. A standardized lipid-enriched test meal showed a marked impairment of TAG-rich lipoprotein (TRL) clearance, especially the exogeneous TRL bearing ApoB-48 which still represented 79 % of total TRL 7 h after the fat load. Finally, differences between the male and female siblings with the existence of a consanguine relationship in their parents suggested the involvement of other genetic factors in modulating the severity of phenotypic expression. This observation reinforces the usefulness of genotyping of ApoE for the characterization of genetic hypertriacylglycerolaemia and selection of the appropriate diet and treatment.

Download Full-text