Molecular library aims to improve new organic LED development

Purine 5′,8-cyclo-2′-deoxynucleosides (cPu) are tandem-type lesions observed among the DNA purine modifications and identified in mammalian cellular DNA in vivo. These lesions can be present in two diasteroisomeric forms, 5′R and 5′S, for each 2′-deoxyadenosine and 2′-deoxyguanosine moiety. They are generated exclusively by hydroxyl radical attack to 2′-deoxyribose units generating C5′ radicals, followed by cyclization with the C8 position of the purine base. This review describes the main recent achievements in the preparation of the cPu molecular library for analytical and DNA synthesis applications for the studies of the enzymatic recognition and repair mechanisms, their impact on transcription and genetic instability, quantitative determination of the levels of lesions in various types of cells and animal model systems, and relationships between the levels of lesions and human health, disease, and aging, as well as the defining of the detection limits and quantification protocols.

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Novel antibody specificities targeting glycoprotein B of cytomegalovirus identified by molecular library technology

New Biotechnology ◽

10.1016/j.nbt.2009.05.003 ◽

2009 ◽

Vol 25 (6) ◽

pp. 429-436 ◽

Cited By ~ 2

Author(s):

Fredrika Axelsson ◽

Jonas Persson ◽

Emmanuel Moreau ◽

Marie-Hélène Côté ◽

Alain Lamarre ◽

...

Keyword(s):

Glycoprotein B ◽

Antibody Specificities ◽

Library Technology ◽

Molecular Library

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Matter–wave interference of particles selected from a molecular library with masses exceeding 10 000 amu

Physical Chemistry Chemical Physics ◽

10.1039/c3cp51500a ◽

2013 ◽

Vol 15 (35) ◽

pp. 14696 ◽

Cited By ~ 143

Author(s):

Sandra Eibenberger ◽

Stefan Gerlich ◽

Markus Arndt ◽

Marcel Mayor ◽

Jens Tüxen

Keyword(s):

Matter Wave ◽

Wave Interference ◽

Molecular Library

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Synthesis and Preliminarily Cytotoxicity to A549, HCT116 and MCF-7 Cell Lines of Thieno[2,3-d]pyrimidine Derivatives Containing Isoxazole Moiety

10.20944/preprints201703.0190.v1 ◽

2017 ◽

Author(s):

Jianping Yong ◽

Canzhong Lu ◽

Xiaoyuan Wu

Keyword(s):

Cell Lines ◽

Anticancer Drugs ◽

Broad Spectrum ◽

Pyrimidine Derivatives ◽

Reference Drug ◽

Drug Candidates ◽

Mtt Method ◽

Novel Structures ◽

Molecular Library ◽

Mcf 7

Under the guidance of our previous achievements, and in order to extend this small molecular library. In current work, other 21 novel structures of thieno[2,3-d]pyrimidines containing isoxazole-moiety (1a-1u) were firstly synthesized and the cytotoxicity to A549, HCT116 and MCF-7 cell lines was evaluated using the MTT method. The results showed that most target compounds exhibited good to excellent cytotoxicity to A549, HCT116 and MCF-7 cell lines, especially 6-Methyl-4-{[3-(4-chlorophenyl)-isoxazol-5-yl-]-methoxy-}-thieno[2,3-d]-pyrimidine (1e) exhibited a broad-spectrum and the most potent cytotoxicity to A549, HCT116 and MCF-7 cell lines (IC50s: 2.79, 6.69 and 4.21×10-3 μM, respectively) as compared with the reference drug gefitinib (IC50s: 17.90, 21.55 and 20.68 μM, respectively). 1e can be seen as the best drug candidates for development of anticancer drugs.

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