scholarly journals Generalized Taylor dispersion for translationally invariant microfluidic systems

2021 ◽  
Vol 33 (8) ◽  
pp. 082004
Author(s):  
A. Alexandre ◽  
T. Guérin ◽  
D. S. Dean

Author(s):  
David E Huber ◽  
Juan G Santiago

Molecular dispersion is caused by both molecular diffusion and non-uniform bulk fluid motion. While the Taylor–Aris dispersion regime is the most familiar regime in microfluidic systems, an oft-overlooked regime is that of purely kinematic (or ballistic) dispersion. In most microfluidic systems, this dispersion regime is transient and quickly gives way to Taylor–Aris dispersion. In electrophoretic focusing methods such as temperature gradient focusing (TGF), however, the characteristic time scales for dispersion are fixed, and focused peaks may never reach the Taylor limit. In this situation, generalized Taylor dispersion analysis is not applicable. A heuristic model is developed here which accounts for both molecular diffusion and advective dispersion across all dispersion regimes, from pure diffusion to Taylor dispersion to pure advection. This model is compared to results from TGF experiments and accurately captures both the initial decrease and subsequent increase in peak widths as electric field strength increases. The results of this combined analytical and experimental study provide a useful tool for estimation of dispersion and optimization of TGF systems.



2010 ◽  
Vol 2 (4) ◽  
pp. 227-238 ◽  
Author(s):  
Gerardo Perozziello ◽  
Giuseppina Simone ◽  
Patrizio Candeloro ◽  
Francesco Gentile ◽  
Natalia Malara ◽  
...  


2013 ◽  
Vol 5 (2) ◽  
pp. 82-96 ◽  
Author(s):  
Yung-Shin Sun ◽  
Ji-Yen Cheng


Author(s):  
Can Huang ◽  
Han Zhang ◽  
Song-I Han ◽  
Arum Han


Talanta ◽  
2021 ◽  
pp. 122533
Author(s):  
Yunhe Yang ◽  
Yang Yang ◽  
Shuangshuang Wang ◽  
Huihui Li ◽  
David Da Yong Chen




Lab on a Chip ◽  
2021 ◽  
Author(s):  
Peer Erfle ◽  
Juliane Riewe ◽  
Heike Bunjes ◽  
Andreas Dietzel

Poorly soluble drugs can be incorporated in lipid carrier nanoparticles to achieve sufficient bioavailability and open up diverse routes of administration. Preparation by antisolvent precipitation in microfluidic systems enables excellent...



Author(s):  
Ann Ramirez ◽  
Mayowa Amosu ◽  
Priscilla Lee ◽  
Katharina Maisel
Keyword(s):  


2007 ◽  
Vol 119 (13) ◽  
pp. 2278-2281 ◽  
Author(s):  
Richard K. P. Benninger ◽  
Oliver Hofmann ◽  
Björn Önfelt ◽  
Ian Munro ◽  
Chris Dunsby ◽  
...  


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