Recombinant bovine somatotropin on heifer’s biometric measures, bodyweight, blood metabolites, and dry matter intake predictions

2018 ◽  
Vol 58 (12) ◽  
pp. 2207
Author(s):  
Jefferson R. Gandra ◽  
Euclides R. Oliveira ◽  
Caio S. Takiya ◽  
Tiago A. Del Valle ◽  
Erika R. S. Gandra ◽  
...  

This study aimed to determine the influence of sustained-release recombinant bovine somatotropin (rbST) injections on biometrics measures, bodyweight (BW), average BW gain, observed and predicted DM intake, accuracy of recent methods to estimate DM intake, blood metabolites, haematological profile and rectal temperature in dairy heifers. Thirty Holstein heifers (132 ± 27 kg BW and 6.2 ± 0.35 months of age) were used in a complete randomised design experiment. Heifers were assigned to treatments: (1) Control (CON), 250 mL of saline solution, or (2) rbST, 250 mg of sustained-release rbST every 15 days. Treatments were injected in the subcutaneous of ischiorectal fossa or subscapular region in a regular alternating manner (right and left side) every 15 days throughout a period of 90 days. Prediction of DM intake was calculated using either non-linear or linear models for heifers in tropical conditions. rbST injections increased the average values of thoracic perimeter, length, and rump width in heifers. rbST-treated heifers had higher average BW and BW gain than CON. Regardless of the model applied, both observed and predicted DM intake were higher for heifers rbST-treated in relation to CON. Non-linear model was accurate without significant bias. rbST injections elevated blood glucose and high-density lipoprotein cholesterol concentration in heifers. No differences were detected on haematological profile and rectal temperature of heifers. rbST injections every 15 days to growing heifers promoted animal performance by increasing biometrics measures and BW gain. In addition, non-linear model was accurate to predict DM intake of heifers.

1990 ◽  
Vol 70 (3) ◽  
pp. 795-809 ◽  
Author(s):  
M. LÉONARD ◽  
M. GALLO ◽  
G. GALLO ◽  
E. BLOCK

Efficacy of a sustained-release formulation of recombinant bovine somatotropin (rbST) was evaluated for two consecutive lactations. In trial 1, 48 multiparous and 12 primiparous Holstein cows were allocated randomly by parity to four treatment groups receiving 0, 320, 640, or 960 mg rbST in a sustained-release formulation at 28-d intervals starting in early, mid-, or late lactation with the total treatment period being 252, 168, or 84 d for the three different starting periods, respectively. Fifteen cows receiving 640 or 960 mg rbST 28 d−1 in trial I received 640 mg rbST 28 d−1 in trial II for a full second lactation and were paired with cows receiving a placebo and which were never administered rbST. Cows were fed total mixed rations ad libitum and milked twice daily. Response in milk and milk component yield was positive and very consistent for multiparous cows between trials. Primiparous cows responded in both lactations with the same numerical magnitude as multiparous cows but with higher variability. No adverse effect of treatment on final body condition score and achievement of proper condition for a subsequent lactation was found because treated cows had lower condition scores for a longer period of time but regained body condition at a faster rate in late lactation. No effect of treatment was observed on health parameters in either lactation. Trends towards longer days open and more breedings per conception were apparent for both lactations. Key words: Somatotropin, milk production, health, dairy cows, primiparous cows


1991 ◽  
Vol 71 (2) ◽  
pp. 343-353 ◽  
Author(s):  
Guillermo F. Gallo ◽  
Elliot Block

Three trials were conducted to determine the effects of recombinant bovine somatotropin (rbST) on reproductive functions of lactating Holstein dairy cows. In Trial 1, 49 cows were used to investigate the effects of 0, 320 or 640 mg of rbST in a sustained-release formulation injected every 28 d on plasma progesterone (P4) concentration during estrous cycles. Total P4 area and P4 mean were increased (P < 0.05) in rbST-treated cows during the 1st and 2nd detected estrous cycle post-rbST injection. Maximum P4 value, slope of the P4 decline and length of cycles were not affected by rbST treatment. In Trial 2, 56 cows were used to investigate the effects of 0, 320, 640 and 960 mg of rbST in a sustained-release preparation injected every 28 d on plasma P4 concentration from weeks 1 to 34 of pregnancy. Mean P4 was increased (P = 0.08) in rbST-treated cows proportionally to the rbST dose received. In Trial 3, 18 cows were used to investigate the effects of 0 or 25 mg d−1 of rbST injected from days 3 to 15 postpartum (pp) on the gonadotropin-releasing hormone (GnRH) induced luteinizing hormone (LH) response curve at 14 d pp. Total area under the LH curve and LH peak value were increased (P < 0.05) in rbST-treated cows, but LH baseline and time to LH peak were not different among groups. Cows receiving rbST were in a more negative energy balance due to higher milk production. In summary, long-term administration of rbST increased the concentration of plasma progesterone during the first two estrous cycles post-treatment and during pregnancy, and enhanced the GnRH-induced LH response at 14 d pp. Key words: Bovine somatotropin, GnRH-LH induction, progesterone, estrous cycle, pregnancy


1993 ◽  
Vol 76 (4) ◽  
pp. 1125-1136 ◽  
Author(s):  
J.V. Downer ◽  
D.L. Patterson ◽  
D.W. Rock ◽  
W.V. Chalupa ◽  
R.M. Cleale ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document