Two New Isonakafurans from the Great Barrier Reef Sponge Dysidea sp. nov.

1998 ◽  
Vol 51 (3) ◽  
pp. 195 ◽  
Author(s):  
Andrew E. Flowers ◽  
Mary J. Garson ◽  
Karl A. Byriel ◽  
Colin H. L. Kennard

Two new sesquiterpenes, the furan Δ7,14-isonakafuran-9 (11) and the autoxidized derivative (12), were isolated from the sponge Dysidea sp. nov. collected from One Tree Island on the Great Barrier Reef. The structures of the two new sesquiterpenes, which both contain a bicyclo[4.3.1]decane skeleton, were deduced by use of one- and two-dimensional n.m.r. spectroscopy, in particular by n.O.e. and HMBC experiments. Compound (11) is isomeric with nakafuran-9 (6) while the hydroperoxide derivative (12) was subjected to X-ray crystallographic analysis to confirm its relative stereochemistry at C1 and C11. Both metabolites have growth inhibitory activity against the P388 cell line, while the hydroperoxide derivative (12) is also inhibitory to the marine fungus Trichophyton mentagrophytes.


Zootaxa ◽  
2009 ◽  
Vol 2260 (1) ◽  
pp. 927-930
Author(s):  
J. K. LOWRY ◽  
H. E. STODDART

One species of wandinid amphipod is reported from the Great Barrier Reef, Queensland, Australia. Wandin griffini Lowry & Stoddart is known from Lizard Island, One Tree Island and reefs on the Outer Barrier, living among rubble usually at the base of living coral. The species is rare in this habitat.







2017 ◽  
Vol 118 (1-2) ◽  
pp. 125-130 ◽  
Author(s):  
Veronique Chazottes ◽  
Pat Hutchings ◽  
Alicia Osorno


1977 ◽  
Vol 24 (1) ◽  
pp. M1-M11 ◽  
Author(s):  
P.J. Davies ◽  
D.W. Kinsey


1997 ◽  
Vol 50 (2) ◽  
pp. 139 ◽  
Author(s):  
Eric J. Dumdei ◽  
Jamie S. Simpson ◽  
Mary J. Garson ◽  
Karl A. Byriel ◽  
Colin H. L. Kennard

Three new chlorinated metabolites, namely 3-(3,3-dichloro-2-methylpropyl)-6-(3,3-dichloro-2-methyl-propylidene)-1,4-dimethylpiperazine-2,5-dione (3), 1-methyl-3-(3,3,3-trichloro-2-methylpropyl)-6-(3,3,3-richloro-2-methylpropylidene)piperazine-2,5-dione (4) and 5,5-dichloro-4-methyl-2-[methyl(4,4-dichloro-3-methyl-1-oxobutyl)amino]-N-(thiazol-2-ylmethyl)pentanamide (8), have been isolated from collections of Dysidea herbacea from the southern region of the Great Barrier Reef. The relative and absolute stereochemistry of (4) was determined by X-ray crystallographic analysis.



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