Potential Combination of Kapok Leaf Extract (Ceiba pentandra G.) and Turmeric Extract (Curcuma domestica Va) as an Anticancer Compound

Combination of kapok leaf extract (Ceiba pertandra G.) and turmeric extract (Curcuma domestica Va.) was carried out to determine the potential of extracts in treating cancer with BSLT and murine cells P388. Cancer is a disease that is very feared because it’s difficult to cure, and even rarely causes death. The sample was extracted with methanol, the extract was mixed so that the mixture extract from the two samples was obtained. The results showed that in the BSLT test the mixed extract had a bioactivity against shrimp larvae with an LC50 value of 142.946 ppm. While in Leukemia P388 cell testing showed that the combination of mixed extracts had a cytotoxic effect on Leukemia P388 cancer cells with inhibitory concentration values of 54.34 ppm. This shows that the kapok leaf extract (Ceiba pentandra G.) and combination of turmeric extract (Curcuma domestica Va.) has potential and can be developed as an anticancer agent because it has an IC50 value that can inhibit murine P388 cell growth and LC50 value which can kill shrimp larvae Artemia salina L.

Cytotoxic Withanolides from the Whole Herb of Physalis angulata L.

Physalis angulata L. is a medicinal plant of the Solanaceae family, which is used to produce a variety of steroids. The present study reports on the cytotoxic withanolides of this plant. The species of Physalis angulata L. was identified by DNA barcoding techniques. Two new withanolides (1–2), together with six known analogues (3–8), were isolated from the whole plant of Physalis angulata L. The structures of these new compounds were determined on the basis of extensive spectroscopic data analyses and electronic circular dichroism (ECD) calculations. The withanolides exhibited strong cytotoxic activities against A549, Hela and p388 cell lines. Furthermore, compounds 1 and 2 induced typical apoptotic cell death in A549 cell line according to the evaluation of the apoptosis-inducing activity by flow cytometric analysis.

Two New Lanostanoid Triterpenes from the Fruit Body of Ganoderma lucidum-the Major Component of SunRecome®

Two new lanostanoid triterpenes named 3β-hydroxy-4,4,14-trimethyl-7,11,15-trioxochol-8-en-24-oic acid (1) and 3β-hydroxy-7,11,12,15,23-pentaoxo-lanost-8-en-26-oic acid (2) were isolated from the fruit bodies of Ganoderma lucidum, which is the major component of the antitumor product SunRecome®. Their cytotoxic activities were assayed in vitro against HeLa, p388, SGC-7901, BEL-7402 cell lines, and the results showed that 1 had IC50 values of 18.00 μM against p388 cell, 12.70 μM against Hela cell, 22.00 μM against BEL-7402 cell, 1.50 μM against SGC-7901 cell and 2 had IC50 values of 9.85 μM against p388 cell, 17.10 μM against Hela cell, 51.00 μM against BEL-7402 cell, 42.00 μM against SGC-7901 cell.

Two New Isonakafurans from the Great Barrier Reef Sponge Dysidea sp. nov.

Two new sesquiterpenes, the furan Δ7,14-isonakafuran-9 (11) and the autoxidized derivative (12), were isolated from the sponge Dysidea sp. nov. collected from One Tree Island on the Great Barrier Reef. The structures of the two new sesquiterpenes, which both contain a bicyclo[4.3.1]decane skeleton, were deduced by use of one- and two-dimensional n.m.r. spectroscopy, in particular by n.O.e. and HMBC experiments. Compound (11) is isomeric with nakafuran-9 (6) while the hydroperoxide derivative (12) was subjected to X-ray crystallographic analysis to confirm its relative stereochemistry at C1 and C11. Both metabolites have growth inhibitory activity against the P388 cell line, while the hydroperoxide derivative (12) is also inhibitory to the marine fungus Trichophyton mentagrophytes.