Synthesis and Antineoplastic Activity of Quinoline Derivatives

2008 ◽  
Vol 61 (7) ◽  
pp. 531 ◽  
Author(s):  
Qiang Zhou ◽  
Jing Hou ◽  
Huamin Li ◽  
Li Cui ◽  
Han Jia ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Structure Activity Relationship ◽  
Biological Evaluation ◽  
Antineoplastic Activity ◽  
Activity Relationship ◽  
Quinoline Derivatives ◽  
Structure Activity ◽  
Relationship Of

Designed as a new series of molecules that contain the quinoline substructure, several 11H-indolo[3.2-c]quinoline derivatives were synthesized and subjected to biological evaluation. Several compounds were found to exhibit cytotoxic activity against the growth of colon (HTC-8), liver (BEL-7402), gastric (BCG-823), pulmonary gland (A549), and ovary (A2780) cancer cell lines. The structure–activity relationship of these compounds is discussed.

scholarly journals Synthesis, Biological Evaluation, and Structure-activity Relationship of Clonazepam, Meclonazepam, and 1,4-Benzodiazepine Compounds with Schistosomicidal Activity

2012 ◽  
Vol 79 (6) ◽  
pp. 943-949 ◽  
Author(s):  
Carla M. S. Menezes ◽  
Gildardo Rivera ◽  
Marina A. Alves ◽  
Daniel N. do Amaral ◽  
Jean Pierre B. Thibaut ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Biological Evaluation ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of

Structure−Activity Relationship of Quinoline Derivatives as Potent and Selective α2C-Adrenoceptor Antagonists

2006 ◽  
Vol 49 (21) ◽  
pp. 6351-6363 ◽  
Author(s):  
Iisa P. J. Höglund ◽  
Satu Silver ◽  
Mia T. Engström ◽  
Harri Salo ◽  
Andrei Tauber ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Quinoline Derivatives ◽  
Structure Activity ◽  
Relationship Of

Structure−Activity Relationship of Newly Synthesized Quinoline Derivatives for Reversal of Multidrug Resistance in Cancer

1997 ◽  
Vol 40 (13) ◽  
pp. 2047-2052 ◽  
Author(s):  
Tsuneji Suzuki ◽  
Nobuyuki Fukazawa ◽  
Kunio San-nohe ◽  
Wakao Sato ◽  
Osamu Yano ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Quinoline Derivatives ◽  
Structure Activity ◽  
Relationship Of

Synthesis, biological evaluation and structure–activity relationship of 2-styrylquinazolones as anti-tubercular agents

2016 ◽  
Vol 26 (11) ◽  
pp. 2663-2669 ◽  
Author(s):  
Pradeep S. Jadhavar ◽  
Tejas M. Dhameliya ◽  
Maulikkumar D. Vaja ◽  
Dinesh Kumar ◽  
Jonnalagadda Padma Sridevi ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Biological Evaluation ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of
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