Synthesis of MUC1 Peptide and Glycopeptide Dendrimers

2009 ◽  
Vol 62 (10) ◽  
pp. 1339 ◽  
Author(s):  
Candy K. Y. Chun ◽  
Richard J. Payne
Keyword(s):  
Peptide Synthesis ◽  
Tandem Repeat ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Cycloaddition Reaction ◽  
Repeat Sequence ◽  
Tandem Repeat Sequence ◽  
Multiple Copies ◽  
Fmoc Strategy

Several dendrimers possessing multiple copies of peptides and glycopeptides belonging to the MUC1 eicosapeptide tandem repeat sequence have been prepared. Fmoc-strategy solid-phase peptide synthesis was used to construct the peptides and glycopeptides, which were conjugated to suitably functionalized dendrimer cores using the copper-catalyzed azide-alkyne cycloaddition reaction to produce multivalent peptide and glycopeptide dendrimers.

Aqueous Microwave-Assisted Solid-Phase Peptide Synthesis Using Fmoc Strategy: In-Water Synthesis of "Difficult Sequences"

2012 ◽  
Vol 19 (11) ◽  
pp. 1231-1236 ◽  
Author(s):  
Keiko Hojo ◽  
Hideki Ichikawa ◽  
Asaki Hara ◽  
Mare Onishi ◽  
Koichi Kawasaki ◽  
...  
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Microwave Assisted ◽  
Difficult Sequences ◽  
Fmoc Strategy

Aqueous Microwave-Assisted Solid-Phase Peptide Synthesis Using Fmoc Strategy. II. Racemization Studies and Water Based Synthesis of Cysteine- Containing Peptides

2013 ◽  
Vol 20 (10) ◽  
pp. 1122-1128 ◽  
Author(s):  
Keiko Hojo ◽  
Natsuki Shinozaki ◽  
Asaki Hara ◽  
Mare Onishi ◽  
Yoshinobu Fukumori ◽  
...  
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Microwave Assisted ◽  
Water Based ◽  
Fmoc Strategy

scholarly journals Sintesis Tetrapeptida Linear (DPAP) Menggunakan Metode Sintesis Peptida Fasa Padat (SPPS) Dan Aktivitas Insektisidanya Terhadap Ulat Krop Kubis

2020 ◽  
Vol 8 (1) ◽  
pp. 6-14
Author(s):  
Eka Fitri Yanti ◽  
Rani Maharani
Keyword(s):  
Peptide Synthesis ◽  
Column Chromatography ◽  
Insecticidal Activity ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Negative Effects ◽  
Reverse Phase ◽  
Linear Peptide ◽  
Fmoc Strategy ◽  
Phase Column

Crop cabbage worm (Crocidolomia pavonana) is one of the pests that has a bad effect on the cabbage production in Indonesia. One of the efforts that has been applied to control this pest is by using bayrusil. However, the bayrusil can cause negative effects such as poisoning and environmentally polluting effects. To prevent the undesired effects, it has been developed the use of environmentally friendly insecticide and one of them is the use of insecticidal peptide. Tripsin-modulating oostatic factor (TMOF) and ist analogues is one of the peptides that has an insecticidal activity. The aim of this research is to synthesise a linear tetrapeptide (DPAP) an analogues of TMOF and to test insecticidal activities against crop cabbage worm.  A DPAP has been synthesised by Solid Phase Peptide Synthesis on 2-chlorotrytil chloride resin. Fmoc strategy was applied on the synthesis and a combination DIC/Oxime was employed in the coupling reaction.The tetrapeptidyl resin was cleaved by TFA:water:EDT (90:5:5). The peptide was purified by reverse-phase column chromatography and characterized by TOF ES-MS spectroscopy. A linear peptide was biologically tested towards the C. pavonana, showing percentage of mortality values at 1000 ppm.

Improved methodologies for solid phase peptide synthesis: Use of a Fmoc strategy with benzhydryl resins

Peptides ◽  
1992 ◽  
pp. 544-545
Author(s):  
Alexander R. Mitchell ◽  
Farzaneh Ghofrani ◽  
Janis Dillaha Young
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Fmoc Strategy

An α-aminoglycine derivative suitable for solid phase peptide synthesis using Fmoc strategy.

1993 ◽  
Vol 34 (24) ◽  
pp. 3861-3862 ◽  
Author(s):  
Driss Qasmi ◽  
Loïc René ◽  
Bernard Badet
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Fmoc Strategy

scholarly journals Aqueous microwave-assisted solid-phase peptide synthesis using Fmoc strategy. III: Racemization studies and water-based synthesis of histidine-containing peptides

Amino Acids ◽  
2014 ◽  
Vol 46 (10) ◽  
pp. 2347-2354 ◽  
Author(s):  
Keiko Hojo ◽  
Natsuki Shinozaki ◽  
Koushi Hidaka ◽  
Yuko Tsuda ◽  
Yoshinobu Fukumori ◽  
...  
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Microwave Assisted ◽  
Water Based ◽  
Fmoc Strategy

A Strategy for Thioamide Incorporation During Fmoc Solid-Phase Peptide Synthesis with Robust Stereochemical Integrity

2019 ◽  
Author(s):  
luis camacho III ◽  
Bryan J. Lampkin ◽  
Brett VanVeller
Keyword(s):  
Amino Acid ◽  
Functional Groups ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Side Chains ◽  
Amino Acid Side Chains ◽  
Peptide Elongation

We describe a method to protect the sensitive stereochemistry of the thioamide—in analogy to the protection of the functional groups of amino acid side chains—in order to preserve the thioamide moiety during peptide elongation.<br>

Analytical Methods for Solid Phase Peptide Synthesis

2004 ◽  
Vol 8 (4) ◽  
pp. 291-301 ◽  
Author(s):  
Giuseppina Sabatino ◽  
Mario Chelli ◽  
Alberto Brandi ◽  
Anna Papini
Keyword(s):  
Peptide Synthesis ◽  
Analytical Methods ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis
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