Hydrolysis of amides. III. Dilute acid hydrolysis of amides of the type R-CH2-CONH2
Keyword(s):
Rate constants over a range of temperature, enthalpies of activation, and entropies of activation are reported for the dilute acid hydrolysis of n-valeramide, isovaleramide, 3,3-dimethylbutanamide, phenylacetamide, cyclohexylacetamide, methoxyacetamide, bromoacetamide, and chloroacetamide. ��� The rate constants of the first six amides together with those of two other alkyl-substituted acetamides taken from a previous paper are almost perfectly correlated by the Taft linear steric energy relationship. The enthalpies of activation, also, show a linear dependence on the steric parameter, Es. The results obtained for the halogeno amides indicate that the acid hydrolysis of amides may show a slight sensitivity to polar effects.
Keyword(s):
2017 ◽
Vol 4
(1)
◽
2008 ◽
Vol 153
(1-3)
◽
pp. 116-126
◽
1985 ◽
Vol 27
(3)
◽
pp. 355-361
◽
Keyword(s):
1999 ◽
pp. 133-142
◽
Keyword(s):
2020 ◽
Vol 61
◽
pp. 104843
◽
Keyword(s):