Isopalinurin: a Mild Protein Phosphatase Inhibitor From a Southern Australian Marine Sponge, Dysidea sp.

1993 ◽  
Vol 46 (8) ◽  
pp. 1291 ◽  
Author(s):  
L Murray ◽  
ATR Sim ◽  
JAP Rostas ◽  
RJ Capon
Keyword(s):  
Marine Sponge ◽  
Protein Phosphatase ◽  
Spectroscopic Analysis ◽  
Ethanol Extract ◽  
Antibiotic Activity ◽  
Tetronic Acid ◽  
Phosphatase Inhibitor ◽  
Protein Phosphatase Inhibitor

A new sesterterpene tetronic acid, isopalinurin (1), has been isolated from an Australian marine sponge, Dysidea sp., collected in Bass Strait. Isopalinurin (1) was identified as the agent responsible for the antibiotic activity and protein phosphatase inhibitory properties exhibited by the crude ethanol extract, and its structure was secured by detailed spectroscopic analysis.

ChemInform Abstract: Isopalinurin (I): A Mild Protein Phosphatase Inhibitor from a Southern Australian Marine Sponge, Dysidea sp.

ChemInform ◽  
2010 ◽  
Vol 24 (48) ◽  
pp. no-no
Author(s):  
L. MURRAY ◽  
A. T. R. SIM ◽  
J. A. P. ROSTAS ◽  
R. J. CAPON
Keyword(s):  
Marine Sponge ◽  
Protein Phosphatase ◽  
Phosphatase Inhibitor ◽  
Protein Phosphatase Inhibitor

Cometins (A-C), New Furanosesterterpenes From an Australian Marine Sponge, Spongia sp.

1992 ◽  
Vol 45 (8) ◽  
pp. 1255 ◽  
Author(s):  
S Urban ◽  
RJ Capon
Keyword(s):  
Marine Sponge ◽  
Spectroscopic Analysis ◽  
Ethanol Extract ◽  
Chemical Derivatization ◽  
Tetronic Acid ◽  
Antibiotic Property ◽  
Great Australian Bight

The known marine furanosesterterpene furospinosulin-1 (1), together with three new furanosesterterpenes, namely cometin-A (2), cometin-B (3) and cometin-C (4), were isolated from a marine sponge, Spongia sp., collected during commercial trawling operations in the Great Australian Bight. The structures of these metabolites were determined by detailed spectroscopic analysis and chemical derivatization . The antibiotic property of the crude ethanol extract of this sponge was attributed solely to the furanosesterterpene tetronic acid cometin -A (2).

On the Cardiac Contractile, Electrophysiological and Biochemical Effects of Endothall, a Protein Phosphatase Inhibitor

Pharmacology ◽  
2000 ◽  
Vol 61 (1) ◽  
pp. 43-50 ◽  
Author(s):  
P. Bokník ◽  
U. Vahlensieck ◽  
S. Huke ◽  
J. Knapp ◽  
B. Linck ◽  
...  
Keyword(s):  
Protein Phosphatase ◽  
Biochemical Effects ◽  
Phosphatase Inhibitor ◽  
Cardiac Contractile ◽  
Protein Phosphatase Inhibitor

scholarly journals Microcystin-LR, a protein phosphatase inhibitor, induces alterations in mitotic chromatin and microtubule organization leading to the formation of micronuclei in Vicia faba

2012 ◽  
Vol 110 (4) ◽  
pp. 797-808 ◽  
Author(s):  
Dániel Beyer ◽  
Ildikó Tándor ◽  
Zoltán Kónya ◽  
Róbert Bátori ◽  
Janos Roszik ◽  
...  
Keyword(s):  
Vicia Faba ◽  
Protein Phosphatase ◽  
Microtubule Organization ◽  
Phosphatase Inhibitor ◽  
Protein Phosphatase Inhibitor ◽  
Mitotic Chromatin

scholarly journals Morphological changes of human myeloid leukemia K562 cells by a protein phosphatase inhibitor, tautomycin.

1990 ◽  
Vol 66 (10) ◽  
pp. 209-212 ◽  
Author(s):  
Junji MAGAE ◽  
Hiroyuki OSADA ◽  
Hirota FUJIKI ◽  
Takaomi C. SAIDO ◽  
Koichi SUZUKI ◽  
...  
Keyword(s):  
Protein Phosphatase ◽  
Myeloid Leukemia ◽  
Morphological Changes ◽  
K562 Cells ◽  
Phosphatase Inhibitor ◽  
Protein Phosphatase Inhibitor
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