scholarly journals Correction for Smith et al., Identification of a Plasmodium falciparum intercellular adhesion molecule-1 binding domain: A parasite adhesion trait implicated in cerebral malaria

2006 ◽  
Vol 103 (32) ◽  
pp. 12209-12209
Keyword(s):  
Plasmodium Falciparum ◽  
Cerebral Malaria ◽  
Adhesion Molecule ◽  
Intercellular Adhesion ◽  
Binding Domain ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1

scholarly journals Rational Design of Anticytoadherence Inhibitors for Plasmodium falciparum Based on the Crystal Structure of Human Intercellular Adhesion Molecule 1

2006 ◽  
Vol 50 (2) ◽  
pp. 724-730 ◽  
Author(s):  
Matthias Dormeyer ◽  
Yvonne Adams ◽  
Bernd Kramer ◽  
Srabasti Chakravorty ◽  
Man Tsuey Tse ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Plasmodium Falciparum ◽  
Binding Site ◽  
Adhesion Molecule ◽  
Rational Design ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Lymphocyte Function ◽  
Dependent Manner ◽  
Intercellular Adhesion Molecule 1

ABSTRACT Adhesion of Plasmodium falciparum-infected erythrocytes (IE) to host endothelium has been associated with pathology in malaria. Although the interaction with endothelial cells can be complex due to the relatively large number of host receptors available for binding, specific proteins have been identified that are more commonly used than others. For example, binding to intercellular adhesion molecule 1 (ICAM 1) is found frequently in parasites from pediatric cases of malaria. The binding site for P. falciparum-infected erythrocytes on ICAM 1 has been mapped in some detail and is distinct from the site for lymphocyte function-associated antigen 1 (LFA-1). Part of the ICAM 1 binding site for P. falciparum-infected erythrocytes (the DE loop) was used to screen a library of compounds based on its structure (derived from the crystal structure of human ICAM 1). This resulted in the identification of 36 structural mimeotopes as potential competitive inhibitors of binding. One of these compounds, (+)-epigalloyl-catechin-gallate [(+)-EGCG], was found to inhibit IE adhesion to ICAM 1 in a dose-dependent manner with two variant ICAM 1-binding parasite lines, providing the first example of a potential mimeotope-based anticytoadherence inhibitor for Plasmodium falciparum.

Expression of Intercellular Adhesion Molecule 1 (ICAM-1) in Plasmodium falciparum -infected Placenta

Placenta ◽  
2001 ◽  
Vol 22 (6) ◽  
pp. 573-579 ◽  
Author(s):  
T. Sugiyama ◽  
L.E. Cuevas ◽  
W. Bailey ◽  
R. Makunde ◽  
K. Kawamura ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Adhesion Molecule ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1

scholarly journals Divergent binding sites on intercellular adhesion molecule-1 (ICAM-1) for variant Plasmodium falciparum isolates

2003 ◽  
Vol 51 (4) ◽  
pp. 1039-1049 ◽  
Author(s):  
Man Tsuey Tse ◽  
Kausik Chakrabarti ◽  
Carolyn Gray ◽  
Chetan E. Chitnis ◽  
Alister Craig
Keyword(s):  
Plasmodium Falciparum ◽  
Adhesion Molecule ◽  
Binding Sites ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1

scholarly journals Fibrinogen Binding to Intercellular Adhesion Molecule 1: Implications for Plasmodium falciparum Adhesion

2002 ◽  
Vol 70 (7) ◽  
pp. 3962-3964 ◽  
Author(s):  
Carolyn Gray ◽  
Alister Craig
Keyword(s):  
Plasmodium Falciparum ◽  
Adhesion Molecule ◽  
Binding Sites ◽  
Cell Adhesion Molecule ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Flow Conditions ◽  
Intercellular Adhesion Molecule 1 ◽  
Fibrinogen Binding ◽  
Endothelial Cell Adhesion

ABSTRACT Intercellular adhesion molecule 1 (ICAM-1) is an endothelial cell adhesion molecule implicated in cerebral malaria. We investigated whether fibrinogen affects Plasmodium falciparum binding to ICAM-1, as the ICAM-1 binding sites of P. falciparum and fibrinogen overlap. We show that fibrinogen dramatically reduces P. falciparum adhesion to ICAM-1 under flow conditions.

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