scholarly journals Retraction for Akimoto et al., Testis-specific protein on Y chromosome (TSPY) represses the activity of the androgen receptor in androgen-dependent testicular germ-cell tumors

2014 ◽  
Vol 111 (6) ◽  
pp. 2398.2-2398
Keyword(s):  
Androgen Receptor ◽  
Germ Cell ◽  
Y Chromosome ◽  
Germ Cell Tumors ◽  
Specific Protein ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell

scholarly journals The Role of the Mouse Y Chromosome on Susceptibility to Testicular Germ Cell Tumors

2009 ◽  
Vol 69 (8) ◽  
pp. 3614-3618 ◽  
Author(s):  
Philip D. Anderson ◽  
Man-Yee Lam ◽  
Christophe Poirier ◽  
Colin E. Bishop ◽  
Joseph H. Nadeau
Keyword(s):  
Germ Cell ◽  
Y Chromosome ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell

Lack of association between the incidence of testicular germ cell tumors and Y-chromosome haplogroups in the Japanese population

2006 ◽  
Vol 13 (9) ◽  
pp. 1212-1217 ◽  
Author(s):  
ASHRAF A EWIS ◽  
JUWON LEE ◽  
TAKUSHI NARODA ◽  
SUSUMU KAGAWA ◽  
YOSHINOBU BABA ◽  
...  
Keyword(s):  
Germ Cell ◽  
Y Chromosome ◽  
Japanese Population ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell

Absence of constitutional Y chromosome AZF deletions in patients with testicular germ cell tumors

Urology ◽  
2005 ◽  
Vol 65 (1) ◽  
pp. 196-201 ◽  
Author(s):  
M.F. Lutke Holzik ◽  
K. Storm ◽  
R.H. Sijmons ◽  
M. D’hollander ◽  
E.G.J.M. Arts ◽  
...  
Keyword(s):  
Germ Cell ◽  
Y Chromosome ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell

Serum Lactate Dehydrogenase Isoenzyme 1 and Relapse in Patients with Nonseminomatous Testicular Germ Cell Tumors Clinical Stage I

2001 ◽  
Vol 40 (4) ◽  
pp. 536-540 ◽  
Author(s):  
Finn Edler von Eyben ◽  
Ebbe Lindegaard Madsen ◽  
Ole Blaabjerg ◽  
Per Hyltoft Petersen ◽  
Hans von der Maase ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Germ Cell ◽  
Clinical Stage ◽  
Germ Cell Tumors ◽  
Serum Lactate ◽  
Stage I ◽  
Serum Lactate Dehydrogenase ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Dehydrogenase Isoenzyme

Molecular Mechanisms of Resistance in Testicular Germ Cell Tumors - clinical Implications

2018 ◽  
Vol 18 (10) ◽  
pp. 967-978 ◽  
Author(s):  
Katarina Kalavska ◽  
Vincenza Conteduca ◽  
Ugo De Giorgi ◽  
Michal Mego
Keyword(s):  
Germ Cell ◽  
Molecular Mechanisms ◽  
Cisplatin Resistance ◽  
Apoptotic Cell ◽  
Germ Cell Tumors ◽  
Treatment Resistance ◽  
Experimental Models ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Repair Capacity

Testicular germ cell tumors (TGCTs) represent the most common malignancy in men aged 15-35. Due to these tumors’ biological and clinical characteristics, they can serve as an appropriate system for studying molecular mechanisms associated with cisplatin-based treatment resistance. This review describes treatment resistance from clinical and molecular viewpoints. Cisplatin resistance is determined by various biological mechanisms, including the modulation of the DNA repair capacity of cancer cells, alterations to apoptotic cell death pathways, deregulation of gene expression pathways, epigenetic alterations and insufficient DNA binding. Moreover, this review describes TGCTs as a model system that enables the study of the cellular features of cancer stem cells in metastatic process and describes experimental models that can be used to study treatment resistance in TGCTs. All of the abovementioned aspects may help to elucidate the molecular mechanisms underlying cisplatin resistance and may help to identify promising new therapeutic targets.

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