Correction: Nucleotide Sequence of Abelson Murine Leukemia Virus Genome: Structural Similarity of its Transforming Gene Product to other Onc Gene Products with Tyrosinespecific Kinase Activity

1983 ◽  
Vol 80 (23) ◽  
pp. 7372-7372 ◽  
Keyword(s):  
Nucleotide Sequence ◽  
Murine Leukemia Virus ◽  
Kinase Activity ◽  
Leukemia Virus ◽  
Structural Similarity ◽  
Virus Genome ◽  
Gene Products ◽  
Abelson Murine Leukemia Virus ◽  
Transforming Gene ◽  
Murine Leukemia

Abelson murine leukemia virus induces platelet-derived growth factor-independent fibroblast growth: correlation with kinase activity and dissociation from full morphologic transformation

1989 ◽  
Vol 9 (1) ◽  
pp. 278-287
Author(s):  
R W Rees-Jones ◽  
M Goldfarb ◽  
S P Goff
Keyword(s):  
Growth Factor ◽  
Murine Leukemia Virus ◽  
Kinase Activity ◽  
Cell Transformation ◽  
Leukemia Virus ◽  
Platelet Derived Growth Factor ◽  
Fibroblast Growth ◽  
Morphological Transformation ◽  
Abelson Murine Leukemia Virus ◽  
Murine Leukemia

Abelson murine leukemia virus (A-MuLV) encodes a single protein product, a tyrosine-specific protein kinase, whose activity is necessary for cell transformation by this retrovirus. Using a defined medium culture system, we demonstrate that transformation of NIH 3T3 fibroblasts by A-MuLV abrogates their normal requirement for platelet-derived growth factor (PDGF) for cell growth. Analysis of constructed insertional mutant viruses revealed an absolute correlation between A-MuLV-encoded tyrosine kinase activity and PDGF-independent fibroblast growth. Sequences of the provirus not required for kinase activity appeared unnecessary for abrogating the fibroblast requirement for PDGF. Conversely, sequences required for kinase activity appeared necessary, suggesting that induction of PDGF-independent fibroblast growth, like cell transformation, is a function of this tyrosine kinase. Fibroblasts transformed by a partially transformation-defective mutant demonstrated incomplete morphological transformation but were still independent of PDGF for growth. Thus, the processes of full morphological transformation and growth factor independence can be partially dissociated.

Lethal effect of the abelson murine leukemia virus transforming gene product

Cell ◽  
1981 ◽  
Vol 27 (3) ◽  
pp. 477-486 ◽  
Author(s):  
Steven F. Ziegler ◽  
Cheryl A. Whitlock ◽  
Steven P. Goff ◽  
Ann Gifford ◽  
Owen N. Witte
Keyword(s):  
Gene Product ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Lethal Effect ◽  
Abelson Murine Leukemia Virus ◽  
Transforming Gene ◽  
Murine Leukemia

The nucleotide sequence of the Akv murine leukemia virus genome

Virology ◽  
1984 ◽  
Vol 134 (1) ◽  
pp. 196-207 ◽  
Author(s):  
M. Etzerodt ◽  
T. Mikkelsen ◽  
F.S. Pedersen ◽  
N.O. Kjeldgaard ◽  
P. Jørgensen
Keyword(s):  
Nucleotide Sequence ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Virus Genome ◽  
Murine Leukemia

scholarly journals Structure of the abelson murine leukemia virus genome

Cell ◽  
1979 ◽  
Vol 18 (4) ◽  
pp. 955-962 ◽  
Author(s):  
Anthony Shields ◽  
Stephen Goff ◽  
Michael Paskind ◽  
Gary Otto ◽  
David Baltimore
Keyword(s):  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Virus Genome ◽  
Abelson Murine Leukemia Virus ◽  
Murine Leukemia

scholarly journals Abelson murine leukemia virus: structural requirements for transforming gene function.

1982 ◽  
Vol 79 (18) ◽  
pp. 5508-5512 ◽  
Author(s):  
A. Srinivasan ◽  
C. Y. Dunn ◽  
Y. Yuasa ◽  
S. G. Devare ◽  
E. P. Reddy ◽  
...  
Keyword(s):  
Gene Function ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Structural Requirements ◽  
Abelson Murine Leukemia Virus ◽  
Transforming Gene ◽  
Murine Leukemia
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