scholarly journals Endogenous inhibitor of nonlysosomal high molecular weight protease and calcium-dependent protease.

1986 ◽  
Vol 83 (20) ◽  
pp. 7588-7592 ◽  
Author(s):  
K. Murakami ◽  
J. D. Etlinger
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Endogenous Inhibitor ◽  
Calcium Dependent ◽  
High Molecular Weight Protease

Calcium-Dependent Cross-Linking Processes in Platelets

1979 ◽  
Author(s):  
I. Cohen ◽  
T. Glaser
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Cross Linking ◽  
Low Molecular Weight ◽  
Tracer Concentration ◽  
Calcium Dependent ◽  
A 23187 ◽  
Polymer Formation ◽  
Total Disappearance ◽  
Low Molecular Weight Proteins

When platelet cytoplasmic Ca2+ is increased by the ionophore A 23187, there is the coincident appearance of a cross-linked polymer and the partial disappearance of five high molecular weight polypeptide bands (> 145,000). The glycoproteins show a partial disappearance of bands lb, IIb and IV and the total disappearance of hands la and Ilia. The disappearance of the protein bands, possibly contributing to the polymer formation, is prevented by histamine, aminoacetonltrile and cystamlne, which, as pseudodonor amines are known Inhibitors of factor XHIa-catalyzed cross-linking. 14C-histamine, at a tracer concentration, was incorporated into the polymer as well as into myosin, glycoproteins IIb and IIIa (α-actinln), actin and two unidentified low-molecular weight proteins. The polymer formed is also apparent in isolated membranes following the iono-phore-stimulated increase in intracellular Ca2+. These findings are unrelated to a proteolytic activity since the platelet Ca2+-dependent proteases are inhibited by leupep-tin. Ca2+-activation of a platelet cytosol transamidase would explain the data obtained. This platelet transamidase(s) may couple membrane proteins to cytoplasmic contra-tlle proteins. Thus, a new concept is proposed for the stabilization of platelet membranes and platelets as they form the hemostatic plug.

Purification and Characterization of a High-Molecular-Weight Protease, Ingensin, from Human Placenta

1986 ◽  
Vol 99 (6) ◽  
pp. 1605-1611 ◽  
Author(s):  
Michio NOJIMA ◽  
Shoichi ISHIURA ◽  
Takeshi YAMAMOTO ◽  
Teruaki OKUYAMA ◽  
Hiroshi FURUYA ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Human Placenta ◽  
Purification And Characterization ◽  
High Molecular Weight Protease

Immunocytochemical localization of the high molecular weight protease in brain

1994 ◽  
Vol 663 (2) ◽  
pp. 341-345 ◽  
Author(s):  
Mazhar N. Malik ◽  
Michael D. Fenko ◽  
Ashfaq M. Sheikh ◽  
Guang Y. Wen ◽  
Henryk M. Wisniewski
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Immunocytochemical Localization ◽  
High Molecular Weight Protease

scholarly journals A high molecular weight protease in the cytosol of rat liver. II. Properties of the purified enzyme.

1986 ◽  
Vol 261 (32) ◽  
pp. 15204-15207 ◽  
Author(s):  
K Tanaka ◽  
T Yoshimura ◽  
A Ichihara ◽  
K Kameyama ◽  
T Takagi
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Rat Liver ◽  
High Molecular Weight Protease
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