scholarly journals Direct demonstration of critical amino acid residues required for cytotoxic T-lymphocyte allorecognition of H-2 class I antigens.

1988 ◽  
Vol 85 (9) ◽  
pp. 3085-3089 ◽  
Author(s):  
E. McLaughlin-Taylor ◽  
C. G. Miyada ◽  
M. McMillan ◽  
R. B. Wallace
Keyword(s):  
Amino Acid ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Class I ◽  
Amino Acid Residues ◽  
Critical Amino Acid ◽  
Direct Demonstration

scholarly journals Definition of Amino Acid Residues on the Epitope Responsible for Recognition by Influenza A Virus H1-Specific, H2-Specific, and H1- and H2-Cross-Reactive Murine Cytotoxic T-Lymphocyte Clones

1998 ◽  
Vol 72 (11) ◽  
pp. 9404-9406 ◽  
Author(s):  
Manabu Tamura ◽  
Koichi Kuwano ◽  
Ichiro Kurane ◽  
Francis A. Ennis
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Influenza A Virus ◽  
T Lymphocyte ◽  
Influenza A ◽  
Cytotoxic T Lymphocyte ◽  
Amino Acid Residues ◽  
Amino Acid Region ◽  
Definition Of ◽  
Conserved Amino Acids

ABSTRACT We defined the epitopes recognized by three influenza A virus-specific, H-2Kd -restricted CD8+ cytotoxic T-lymphocyte (CTL) clones: H1-specific clone A-12, H2-specific clone F-4, and H1- and H2-cross-reactive clone B7-B7. The A-12 and B7-B7 clones recognized the same peptide, which comprises amino acids 533 to 541 (IYSTVASSL) of A/PR/8 hemagglutinin (HA). The F-4 and B7-B7 clones both recognized the peptide which comprise amino acids 529 to 537 (IYATVAGSL) of A/Jap HA. Amino acids 533 to 541 of A/PR/8 HA are compatible with amino acids 529 to 537 of A/Jap HA. Amino acid S at positions 3 and 7 was responsible for recognition by H1-specific clone A-12, while amino acid G at position 7 was responsible for recognition by H2-specific clone F-4. Two conserved amino acids, T at position 4 and A at position 6, were responsible for recognition by H1-, and H2-cross-reactive clone B7-B7. These results indicate that a single nine-amino-acid region is recognized by HA-specific CTL clones of three different subtype specificities and that the amino acids responsible for the recognition by the CTL clones are different.

scholarly journals Identification of the murine H-2Db and human HLA-A*0201 MHC class I-restricted HPV6 E7-specific cytotoxic T lymphocyte epitopes

2016 ◽  
Vol 65 (3) ◽  
pp. 261-271 ◽  
Author(s):  
Shiwen Peng ◽  
Austin Mattox ◽  
Simon R. Best ◽  
Anca M. Barbu ◽  
James A. Burns ◽  
...  
Keyword(s):  
Mhc Class I ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Class I

Virosome-mediated delivery of protein antigens in vivo: efficient induction of class I MHC-restricted cytotoxic T lymphocyte activity

Vaccine ◽  
2005 ◽  
Vol 23 (10) ◽  
pp. 1232-1241 ◽  
Author(s):  
Laura Bungener ◽  
Anke Huckriede ◽  
Arjan de Mare ◽  
Jacqueline de Vries-Idema ◽  
Jan Wilschut ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Class I ◽  
Protein Antigens ◽  
Class I Mhc ◽  
Efficient Induction ◽  
Lymphocyte Activity
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