scholarly journals Significant enlargement of a specific subset of CD3+CD8+ peripheral blood leukocytes mediating cytotoxic T-lymphocyte activity during human immunodeficiency virus infection.

1993 ◽  
Vol 90 (20) ◽  
pp. 9427-9430 ◽  
Author(s):  
A. Bensussan ◽  
C. Rabian ◽  
V. Schiavon ◽  
D. Bengoufa ◽  
G. Leca ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes ◽  
Specific Subset ◽  
Immunodeficiency Virus ◽  
Lymphocyte Activity

scholarly journals Human Immunodeficiency Virus (HIV)–Specific Cytotoxic T Lymphocyte Activity in HIV‐Exposed Seronegative Persons

1999 ◽  
Vol 179 (3) ◽  
pp. 538-547 ◽  
Author(s):  
Nicole F. Bernard ◽  
Christina M. Yannakis ◽  
Jimmy S. Lee ◽  
Christos M. Tsoukas
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Immunodeficiency Virus ◽  
Lymphocyte Activity ◽  
Hiv Exposed

scholarly journals Prior Vaccination Increases the Epitopic Breadth of the Cytotoxic T-Lymphocyte Response That Evolves in Rhesus Monkeys following a Simian-Human Immunodeficiency Virus Infection

2002 ◽  
Vol 76 (12) ◽  
pp. 6376-6381 ◽  
Author(s):  
Sampa Santra ◽  
Dan H. Barouch ◽  
Marcelo J. Kuroda ◽  
Jörn E. Schmitz ◽  
Georgia R. Krivulka ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
T Lymphocyte ◽  
Rhesus Monkeys ◽  
Cytotoxic T Lymphocyte ◽  
Virus Challenge ◽  
Modified Vaccinia Virus Ankara ◽  
Immunodeficiency Virus ◽  
Ctl Responses

ABSTRACT Although recent evidence has confirmed the importance of cytotoxic T-lymphocyte (CTL) responses in controlling human immunodeficiency virus type 1 and simian immunodeficiency virus replication, the relevance of the epitopic breadth of those CTL responses remains unexplored. In the present study, we sought to determine whether vaccination can expand CTL populations which recognize a repertoire of viral epitopes that is greater than is typically generated in the course of a viral infection. We demonstrate that potent secondary CTL responses to subdominant epitopes are rapidly generated following a pathogenic simian-human immunodeficiency virus challenge of rhesus monkeys vaccinated with plasmid DNA or recombinant modified vaccinia virus Ankara vaccines. These data indicate that prior vaccination can increase the breadth of the CTL response that evolves after an AIDS virus infection.

scholarly journals Kinetics of Virus-Specific CD8+ T Cells and the Control of Human Immunodeficiency Virus Infection

2004 ◽  
Vol 78 (18) ◽  
pp. 10096-10103 ◽  
Author(s):  
Miles P. Davenport ◽  
Ruy M. Ribeiro ◽  
Alan S. Perelson
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
Viral Replication ◽  
Cytotoxic T Lymphocyte ◽  
Viral Kinetics ◽  
Viral Loads ◽  
Immunodeficiency Virus ◽  
Kinetics Of

ABSTRACT Several primate models indicate that cytotoxic T lymphocyte-inducing vaccines may be unable to prevent human immunodeficiency virus infection but may have a long-term benefit in controlling viral replication and delaying disease progression. Here we show that analysis of the kinetics of antigen-specific CD8+ T-cell expansion suggests a delay in activation following infection that allows unimpeded early viral replication. Viral kinetics do not differ between controls and vaccinees during this delay phase. An increase in virus-specific CD8+ T-cell numbers around day 10 postinfection coincides with a slowing in viral replication in vaccinees and reduces peak viral loads by around 1 log. However, this response is too little too late to prevent establishment of persistent infection.

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