scholarly journals Conditional reduction of human immunodeficiency virus type 1 replication by a gain-of-herpes simplex virus 1 thymidine kinase function.

1996 ◽  
Vol 93 (15) ◽  
pp. 7955-7960 ◽  
Author(s):  
S. M. Smith ◽  
R. B. Markham ◽  
K. T. Jeang
Keyword(s):  
Human Immunodeficiency Virus ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Thymidine Kinase ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Herpes Simplex Virus 1 ◽  
Immunodeficiency Virus ◽  
Simplex Virus

scholarly journals Herpes Simplex Virus Infection Induces Replication of Human Immunodeficiency Virus Type 1

Virology ◽  
2000 ◽  
Vol 278 (2) ◽  
pp. 534-540 ◽  
Author(s):  
Masako Moriuchi ◽  
Hiroyuki Moriuchi ◽  
Richard Williams ◽  
Stephen E. Straus
Keyword(s):  
Human Immunodeficiency Virus ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Herpes Simplex Virus Infection ◽  
Immunodeficiency Virus ◽  
Simplex Virus

scholarly journals Analysis of Select Herpes Simplex Virus 1 (HSV-1) Proteins for Restriction of Human Immunodeficiency Virus Type 1 (HIV-1): HSV-1 gM Protein Potently Restricts HIV-1 by Preventing Intracellular Transport and Processing of Env gp160

2017 ◽  
Vol 92 (2) ◽  
Author(s):  
Sachith Polpitiya Arachchige ◽  
Wyatt Henke ◽  
Ankita Pramanik ◽  
Maria Kalamvoki ◽  
Edward B. Stephens
Keyword(s):  
Human Immunodeficiency Virus ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Human Immunodeficiency Virus Type ◽  
Herpes Simplex Virus 1 ◽  
Immunodeficiency Virus ◽  
Simplex Virus ◽  
Hiv 1 ◽  
Hsv 1

ABSTRACTVirus-encoded proteins that impair or shut down specific host cell functions during replication can be used as probes to identify potential proteins/pathways used in the replication of viruses from other families. We screened nine proteins from herpes simplex virus 1 (HSV-1) for the ability to enhance or restrict human immunodeficiency virus type 1 (HIV-1) replication. We show that several HSV-1 proteins (glycoprotein M [gM], US3, and UL24) potently restricted the replication of HIV-1. Unlike UL24 and US3, which reduced viral protein synthesis, we observed that gM restriction of HIV-1 occurred through interference with the processing and transport of gp160, resulting in a significantly reduced level of mature gp120/gp41 released from cells. Finally, we show that an HSV-1 gM mutant lacking the majority of the C-terminal domain (HA-gM[Δ345-473]) restricted neither gp160 processing nor the release of infectious virus. These studies identify proteins from heterologous viruses that can restrict viruses through novel pathways.IMPORTANCEHIV-1 infection of humans results in AIDS, characterized by the loss of CD4+T cells and increased susceptibility to opportunistic infections. Both HIV-1 and HSV-1 can infect astrocytes and microglia of the central nervous system (CNS). Thus, the identification of HSV-1 proteins that directly restrict HIV-1 or interfere with pathways required for HIV-1 replication could lead to novel antiretroviral strategies. The results of this study show that select viral proteins from HSV-1 can potently restrict HIV-1. Further, our results indicate that the gM protein of HSV-1 restricts HIV-1 through a novel pathway by interfering with the processing of gp160 and its incorporation into virus maturing from the cell.

scholarly journals Recent Herpes Simplex Virus Type 2 Infection and the Risk of Human Immunodeficiency Virus Type 1 Acquisition in India

2003 ◽  
Vol 187 (10) ◽  
pp. 1513-1521 ◽  
Author(s):  
Steven J. Reynolds ◽  
Arun R. Risbud ◽  
Mary E. Shepherd ◽  
Jonathan M. Zenilman ◽  
Ronald S. Brookmeyer ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Immunodeficiency Virus ◽  
Simplex Virus

Triple Retinal Infection with Human Immunodeficiency Virus Type 1, Cytomegalovirus, and Herpes Simplex Virus Type 1

Ophthalmology ◽  
1994 ◽  
Vol 101 (2) ◽  
pp. 270-279 ◽  
Author(s):  
Volker Rummelt ◽  
Carmen Rummelt ◽  
Gerhard Jahn ◽  
Hartmut Wenkell ◽  
Christian Sinzger ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Immunodeficiency Virus ◽  
Simplex Virus

scholarly journals Herpes simplex virus type 2 infection increases human immunodeficiency virus type 1 entry into human primary macrophages

2011 ◽  
Vol 8 (1) ◽  
pp. 166 ◽  
Author(s):  
Elena Sartori ◽  
Arianna Calistri ◽  
Cristiano Salata ◽  
Claudia Del Vecchio ◽  
Giorgio Palù ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Immunodeficiency Virus ◽  
Simplex Virus
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