scholarly journals Bradykinin inhibits M current via phospholipase C and Ca2+ release from IP3-sensitive Ca2+ stores in rat sympathetic neurons

1998 ◽  
Vol 95 (12) ◽  
pp. 7151-7156 ◽  
Author(s):  
H. Cruzblanca ◽  
D.-S. Koh ◽  
B. Hille
Keyword(s):  
Phospholipase C ◽  
Sympathetic Neurons ◽  
M Current

The Anticonvulsant Drug Retigabine Enhances M-current and Reduces Neuronal Excitability in Bullfrog Sympathetic Neurons

BIOS ◽  
2010 ◽  
Vol 81 (2) ◽  
pp. 55-61
Author(s):  
Rebecca Riblet ◽  
Amanpreet Kaur ◽  
Harleen Kaur ◽  
Mark D. Womble
Keyword(s):  
Neuronal Excitability ◽  
Sympathetic Neurons ◽  
Anticonvulsant Drug ◽  
M Current

Hyperpolarizing shift of the M-current activation curve after washout of muscarine in bullfrog sympathetic neurons

1996 ◽  
Vol 207 (2) ◽  
pp. 97-100 ◽  
Author(s):  
Takayuki Tokimasa ◽  
Mark A. Simmons ◽  
Carla R. Schneider ◽  
Takashi Akasu
Keyword(s):  
Sympathetic Neurons ◽  
Activation Curve ◽  
M Current ◽  
Current Activation ◽  
Hyperpolarizing Shift

Mechanisms underlying the M-current block by barium in bullfrog sympathetic neurons

2000 ◽  
Vol 285 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Susumu Kotani ◽  
Takae Hirasawa ◽  
Tomotaro Suzuki ◽  
Kazunori Sato ◽  
Manabu Sakakibara ◽  
...  
Keyword(s):  
Sympathetic Neurons ◽  
M Current ◽  
Current Block

scholarly journals Contribution of KCNQ and TREK Channels to the Resting Membrane Potential in Sympathetic Neurons at Physiological Temperature

2020 ◽  
Vol 21 (16) ◽  
pp. 5796
Author(s):  
Paula Rivas-Ramírez ◽  
Antonio Reboreda ◽  
Lola Rueda-Ruzafa ◽  
Salvador Herrera-Pérez ◽  
Jose Antonio Lamas
Keyword(s):  
Membrane Potential ◽  
Room Temperature ◽  
Sympathetic Neurons ◽  
K Channel ◽  
Resting Membrane Potential ◽  
Physiological Temperature ◽  
M Current ◽  
Key Players ◽  
Cervical Ganglion ◽  
Ionic Mechanisms

The ionic mechanisms controlling the resting membrane potential (RMP) in superior cervical ganglion (SCG) neurons have been widely studied and the M-current (IM, KCNQ) is one of the key players. Recently, with the discovery of the presence of functional TREK-2 (TWIK-related K+ channel 2) channels in SCG neurons, another potential main contributor for setting the value of the resting membrane potential has appeared. In the present work, we quantified the contribution of TREK-2 channels to the resting membrane potential at physiological temperature and studied its role in excitability using patch-clamp techniques. In the process we have discovered that TREK-2 channels are sensitive to the classic M-current blockers linopirdine and XE991 (IC50 = 0.310 ± 0.06 µM and 0.044 ± 0.013 µM, respectively). An increase from room temperature (23 °C) to physiological temperature (37 °C) enhanced both IM and TREK-2 currents. Likewise, inhibition of IM by tetraethylammonium (TEA) and TREK-2 current by XE991 depolarized the RMP at room and physiological temperatures. Temperature rise also enhanced adaptation in SCG neurons which was reduced due to TREK-2 and IM inhibition by XE991 application. In summary, TREK-2 and M currents contribute to the resting membrane potential and excitability at room and physiological temperature in the primary culture of mouse SCG neurons.

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