Evaluation of Eye Lens Dose Reduction Technics in Head CT

The purpose of this study is to find the best protocol to reduce the X-ray dose to the eye lens during head diagnostic computed tomography (CT) without decreasing image quality in the organs of interest according to the type of scanner. The lens of the eye is one of radiosensitive tissues in the body. Radiation induced cataract has been demonstrated among staff involved in interventional procedures using X-rays. This study compares the absorbed dose and image quality of several dose reduction technics to the eye lens during head CT exam namely bismuth shielding, organ-based dose modulation, tube current modulation, tube voltage modulation and the combination of a number of these techniques. Compared to the reference scan (Fixed tube current without bismuth shielding), the dose to the eye lens was reduced by 29.91% with bismuth shield, 14.55% with tube current modulation, 37.76% with tube current modulation and bismuth shield. The combination of organ-based dose modulation with tube voltage modulation reduced the dose by 44.93% that of tube current modulation with tube voltage modulation reduced by 19.03% and that of tube current modulation with tube voltage modulation and shield by 46.73%. The combination of organ-based dose with tube voltage modulation provided superior image quality than that of tube current modulation with tube voltage modulation and shield while similarly reducing dose to the eye lens.

Light shifts in the rubidium CPT atomic clock with laser current modulation at 3.4 and 6.8 GHz

In the paper presents results of an experimental comparison of the CPT parameters of the resonance at the D1 line in 87Rb when the laser current is modulated at frequencies 3.4 GHz and 6.8 GHz. Resonances are investigated for slope to noise ratio (Q-factor) and shifts from the microwave power. The reproducibility of the parameters of VCSEL lasers required to obtain long-term stability of an atomic clock is considered. The obtained CPT instabilities of the atomic clock for 1 second were 1.2·10−11 for the case of 3.4 GHz and 4·10−12 for 6.8 GHz.

Sparsely Distributed, Pre-synaptic Kv3 K+ Channels Control Spontaneous Firing and Cross-Unit Synchrony via the Regulation of Synaptic Noise in an Auditory Brainstem Circuit

Spontaneous subthreshold activity in the central nervous system is fundamental to information processing and transmission, as it amplifies and optimizes sub-threshold signals, thereby improving action potential initiation and maintaining reliable firing. This form of spontaneous activity, which is frequently considered noise, is particularly important at auditory synapses where acoustic information is encoded by rapid and temporally precise firing rates. In contrast, when present in excess, this form of noise becomes detrimental to acoustic information as it contributes to the generation and maintenance of auditory disorders such as tinnitus. The most prominent contribution to subthreshold noise is spontaneous synaptic transmission (synaptic noise). Although numerous studies have examined the role of synaptic noise on single cell excitability, little is known about its pre-synaptic modulation owing in part to the difficulties of combining noise modulation with monitoring synaptic release. Here we study synaptic noise in the auditory brainstem dorsal cochlear nucleus (DCN) of mice and show that pharmacological potentiation of Kv3 K+ currents reduces the level of synaptic bombardment onto DCN principal fusiform cells. Using a transgenic mouse line (SyG37) expressing SyGCaMP2-mCherry, a calcium sensor that targets pre-synaptic terminals, we show that positive Kv3 K+ current modulation decreases calcium influx in a fifth of pre-synaptic boutons. Furthermore, while maintaining rapid and precise spike timing, positive Kv3 K+ current modulation increases the synchronization of local circuit neurons by reducing spontaneous activity. In conclusion, our study identifies a unique pre-synaptic mechanism which reduces synaptic noise at auditory synapses and contributes to the coherent activation of neurons in a local auditory brainstem circuit. This form of modulation highlights a new therapeutic target, namely the pre-synaptic bouton, for ameliorating the effects of hearing disorders which are dependent on aberrant spontaneous activity within the central auditory system.

Locking Phenomena in Semiconductor Lasers near Threshold with Optical Feedback and Sinusoidal Current Modulation

The dynamics of semiconductor lasers with optical feedback and current modulation has been extensively studied, and it is, by now, well known that the interplay of modulation and feedback can produce a rich variety of nonlinear phenomena. Near threshold, in the so-called low frequency fluctuations regime, the intensity emitted by the laser, without modulation, exhibits feedback-induced spikes, which occur at irregular times. When the laser current is sinusoidally modulated, under appropriate conditions, the spikes lock to the modulation and become periodic. In previous works, we studied experimentally the locked behavior and found sub-harmonic locking (regular spike timing such that a spike is emitted every two or three modulation cycles), but we did not find spikes with regular timing, emitted every modulation cycle. To understand why 1:1 regular locking was not observed, here, we perform simulations of the well-known Lang–Kobayashi model. We find a good qualitative agreement with the experiments: with small modulation amplitudes, we find wide parameter regions in which the spikes are sub-harmonically locked to the modulation, while 1:1 locking occurs at much higher modulation amplitudes.