scholarly journals DNA Binding and Bending by the Human Papillomavirus Type 16 E2 Protein

1997 ◽  
Vol 272 (13) ◽  
pp. 8236-8242 ◽  
Author(s):  
Alison Thain ◽  
Kenneth Webster ◽  
Dave Emery ◽  
Anthony R. Clarke ◽  
Kevin Gaston
Keyword(s):  
Human Papillomavirus ◽  
Dna Binding ◽  
E2 Protein ◽  
Human Papillomavirus Type 16 ◽  
Dna Binding And Bending

scholarly journals p53 represses human papillomavirus type 16 DNA replication via the viral E2 protein

2008 ◽  
Vol 5 (1) ◽  
pp. 5 ◽  
Author(s):  
Craig Brown ◽  
Anna M Kowalczyk ◽  
Ewan R Taylor ◽  
Iain M Morgan ◽  
Kevin Gaston
Keyword(s):  
Human Papillomavirus ◽  
Dna Replication ◽  
E2 Protein ◽  
Human Papillomavirus Type 16

A Mutation Study of the DNA Binding Domain of Human Papillomavirus Typell E2 Protein

1997 ◽  
Vol 121 (1) ◽  
pp. 138-144 ◽  
Author(s):  
T. Matsumoto ◽  
N. Nakashima ◽  
K. Takase ◽  
H. Hirochika ◽  
H. Mizuno
Keyword(s):  
Human Papillomavirus ◽  
Dna Binding ◽  
Binding Domain ◽  
Dna Binding Domain ◽  
E2 Protein

Inverse relationship between the expression of the human papillomavirus type 16 transcription factor E2 and virus DNA copy number during the progression of cervical intraepithelial neoplasia

Microbiology ◽  
2000 ◽  
Vol 81 (7) ◽  
pp. 1825-1832 ◽  
Author(s):  
Mark Stevenson ◽  
Lucy C. Hudson ◽  
Julie E. Burns ◽  
Roy L. Stewart ◽  
Michael Wells ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Cervical Intraepithelial Neoplasia ◽  
Intraepithelial Neoplasia ◽  
Lower Grade ◽  
Invasive Squamous Cell Carcinoma ◽  
Hpv 16 ◽  
E2 Protein ◽  
Hpv Dna ◽  
Human Papillomavirus Type 16 ◽  
Invasive Carcinomas

The human papillomavirus type 16 (HPV-16) status of 43 cervical biopsies, which had been characterized histologically as normal, various grades of cervical intraepithelial neoplasia (CIN) and invasive squamous cell carcinoma, was examined by using (i) a novel antibody against the HPV-16 E2 protein, (ii) sensitive HPV-16 DNA in situ hybridization and (iii) microdissection/PCR for the E2 ORF. The data indicate that E2 protein expression is highest in koilocytes in lower-grade CIN (I), but decreases with increasing grade, whereas the detection of HPV DNA is delayed until CIN I/II, rising to the highest levels in carcinoma cells. Co-localization of E2 with HPV-16 DNA-positive cells was most commonly observed in koilocytes in CIN II lesions. PCR analyses of microdissected epithelium from the same or serial sections indicated that E2 ORFs were retained in an intact form in a number of higher-grade CIN lesions and invasive carcinomas.

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