Identification by Mutagenesis of Conserved Arginine and Tryptophan Residues in Rat Liver Carnitine Palmitoyltransferase I Important for Catalytic Activity

Jia Dai; Hongfa Zhu; Jianying Shi; Gebre Woldegiorgis

doi:10.1074/jbc.m002118200

Identification by Mutagenesis of Conserved Arginine and Tryptophan Residues in Rat Liver Carnitine Palmitoyltransferase I Important for Catalytic Activity

Journal of Biological Chemistry ◽

10.1074/jbc.m002118200 ◽

2000 ◽

Vol 275 (29) ◽

pp. 22020-22024 ◽

Cited By ~ 18

Author(s):

Jia Dai ◽

Hongfa Zhu ◽

Jianying Shi ◽

Gebre Woldegiorgis

Keyword(s):

Catalytic Activity ◽

Rat Liver ◽

Carnitine Palmitoyltransferase ◽

Tryptophan Residues ◽

Carnitine Palmitoyltransferase I

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Expression of a cDNA for rat liver carnitine palmitoyltransferase I in yeast establishes that catalytic activity and malonyl-CoA sensitivity reside in a single polypeptide

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)47213-4 ◽

1994 ◽

Vol 269 (42) ◽

pp. 26438-26442

Author(s):

N F Brown ◽

V Esser ◽

D W Foster ◽

J D McGarry

Keyword(s):

Catalytic Activity ◽

Rat Liver ◽

Carnitine Palmitoyltransferase ◽

Malonyl Coa ◽

Carnitine Palmitoyltransferase I ◽

Single Polypeptide

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Identification by Mutagenesis of Conserved Arginine and Glutamate Residues in the C-terminal Domain of Rat Liver Carnitine Palmitoyltransferase I That Are Important for Catalytic Activity and Malonyl-CoA Sensitivity

Journal of Biological Chemistry ◽

10.1074/jbc.m210566200 ◽

2003 ◽

Vol 278 (13) ◽

pp. 11145-11149 ◽

Cited By ~ 10

Author(s):

Michelle Treber ◽

Jia Dai ◽

Gebre Woldegiorgis

Keyword(s):

Catalytic Activity ◽

Rat Liver ◽

Carnitine Palmitoyltransferase ◽

Terminal Domain ◽

Malonyl Coa ◽

Carnitine Palmitoyltransferase I

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Cloning, sequencing, and expression of a cDNA encoding rat liver carnitine palmitoyltransferase I. Direct evidence that a single polypeptide is involved in inhibitor interaction and catalytic function.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)53392-5 ◽

1993 ◽

Vol 268 (8) ◽

pp. 5817-5822 ◽

Cited By ~ 1

Author(s):

V. Esser ◽

C.H. Britton ◽

B.C. Weis ◽

D.W. Foster ◽

J.D. McGarry

Keyword(s):

Rat Liver ◽

Direct Evidence ◽

Carnitine Palmitoyltransferase ◽

Catalytic Function ◽

Carnitine Palmitoyltransferase I ◽

Single Polypeptide ◽

Sequencing And Expression ◽

Inhibitor Interaction

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Identification by Mutagenesis of a Conserved Glutamate (Glu487) Residue Important for Catalytic Activity in Rat Liver Carnitine Palmitoyltransferase II

Journal of Biological Chemistry ◽

10.1074/jbc.m202914200 ◽

2002 ◽

Vol 277 (44) ◽

pp. 42219-42223 ◽

Cited By ~ 5

Author(s):

Guolu Zheng ◽

Jia Dai ◽

Gebre Woldegiorgis

Keyword(s):

Catalytic Activity ◽

Rat Liver ◽

Carnitine Palmitoyltransferase ◽

Carnitine Palmitoyltransferase Ii

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Pig Muscle Carnitine Palmitoyltransferase I (CPTIβ), with LowKmfor Carnitine and Low Sensitivity to Malonyl-CoA Inhibition, Has Kinetic Characteristics Similar to Those of the Rat Liver (CPTIα) Enzyme†

Biochemistry ◽

10.1021/bi0488597 ◽

2004 ◽

Vol 43 (39) ◽

pp. 12686-12691 ◽

Cited By ~ 8

Author(s):

Joana Relat ◽

Carine Nicot ◽

Mar Gacias ◽

Gebre Woldegiorgis ◽

Pedro F. Marrero ◽

...

Keyword(s):

Rat Liver ◽

Carnitine Palmitoyltransferase ◽

Kinetic Characteristics ◽

Malonyl Coa ◽

Pig Muscle ◽

Carnitine Palmitoyltransferase I ◽

Low Sensitivity

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Biogenesis of the Rat Liver Mitochondrial Carnitine Palmitoyltransferase I

Current Views of Fatty Acid Oxidation and Ketogenesis - Advances in Experimental Medicine and Biology ◽

10.1007/0-306-46818-2_1 ◽

2006 ◽

pp. 1-16 ◽

Cited By ~ 1

Author(s):

Isabelle Cohen ◽

Jean Girard ◽

Carina Prip-Buus

Keyword(s):

Rat Liver ◽

Carnitine Palmitoyltransferase ◽

Carnitine Palmitoyltransferase I

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Identification of Positive and Negative Determinants of Malonyl-CoA Sensitivity and Carnitine Affinity within the Amino Termini of Rat Liver- and Muscle-type Carnitine Palmitoyltransferase I

Journal of Biological Chemistry ◽

10.1074/jbc.m007722200 ◽

2000 ◽

Vol 275 (49) ◽

pp. 38410-38416 ◽

Cited By ~ 34

Author(s):

Vicky N. Jackson ◽

Victor A. Zammit ◽

Nigel T. Price

Keyword(s):

Rat Liver ◽

Carnitine Palmitoyltransferase ◽

Muscle Type ◽

Malonyl Coa ◽

Carnitine Palmitoyltransferase I

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Subcellular Distributuon of Mitochondrial Carnitine Palmitoyltransferase I in Rat Liver

Current Views of Fatty Acid Oxidation and Ketogenesis - Advances in Experimental Medicine and Biology ◽

10.1007/0-306-46818-2_2 ◽

2002 ◽

pp. 17-25 ◽

Cited By ~ 3

Author(s):

Fiona Fraser ◽

Clark G. Corstorphine ◽

Victor A. Zammit

Keyword(s):

Rat Liver ◽

Carnitine Palmitoyltransferase ◽

Carnitine Palmitoyltransferase I

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Identification of Conserved Amino Acid Residues in Rat Liver Carnitine Palmitoyltransferase I Critical for Malonyl-CoA Inhibition

Journal of Biological Chemistry ◽

10.1074/jbc.m209999200 ◽

2002 ◽

Vol 278 (11) ◽

pp. 9058-9063 ◽

Cited By ~ 56

Author(s):

Montserrat Morillas ◽

Paulino Gómez-Puertas ◽

Assia Bentebibel ◽

Eva Sellés ◽

Nuria Casals ◽

...

Keyword(s):

Amino Acid ◽

Rat Liver ◽

Carnitine Palmitoyltransferase ◽

Amino Acid Residues ◽

Malonyl Coa ◽

Carnitine Palmitoyltransferase I

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Evidence that the AMP-activated protein kinase stimulates rat liver carnitine palmitoyltransferase I by phosphorylating cytoskeletal components

FEBS Letters ◽

10.1016/s0014-5793(98)01400-8 ◽

1998 ◽

Vol 439 (3) ◽

pp. 317-320 ◽

Cited By ~ 34

Author(s):

Guillermo Velasco ◽

Teresa Gómez del Pulgar ◽

David Carling ◽

Manuel Guzmán

Keyword(s):

Protein Kinase ◽

Rat Liver ◽

Carnitine Palmitoyltransferase ◽

Carnitine Palmitoyltransferase I ◽

Amp Activated Protein Kinase

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