IRF3 and IRF7 Phosphorylation in Virus-infected Cells Does Not Require Double-stranded RNA-dependent Protein Kinase R or IκB Kinase but Is Blocked by Vaccinia Virus E3L Protein

Double Stranded Rna ◽

Iκb Kinase ◽

Dependent Protein ◽

Infected Cells

Interferon-mediated, double-stranded RNA-dependent protein kinase is inhibited in extracts from vaccinia virus-infected cells.

Journal of Virology ◽

10.1128/jvi.50.1.229-236.1984 ◽

1984 ◽

Vol 50 (1) ◽

pp. 229-236 ◽

Cited By ~ 52

Author(s):

A P Rice ◽

I M Kerr

Keyword(s):

Protein Kinase ◽

Vaccinia Virus ◽

Double Stranded Rna ◽

Dependent Protein ◽

Infected Cells

JNK-deficiency enhanced oncolytic vaccinia virus replication and blocked activation of double-stranded RNA-dependent protein kinase

Cancer Gene Therapy ◽

10.1038/cgt.2008.32 ◽

2008 ◽

Vol 15 (9) ◽

pp. 616-624 ◽

Cited By ~ 15

Author(s):

W Hu ◽

W Hofstetter ◽

W Guo ◽

H Li ◽

A Pataer ◽

...

Keyword(s):

Protein Kinase ◽

Vaccinia Virus ◽

Virus Replication ◽

Double Stranded Rna ◽

Characterization of a vaccinia virus-encoded double-stranded RNA-binding protein that may be involved in inhibition of the double-stranded rna-dependent protein kinase

Virology ◽

10.1016/0042-6822(91)90768-7 ◽

1991 ◽

Vol 185 (1) ◽

pp. 206-216 ◽

Cited By ~ 78

Author(s):

Julia C. Watson ◽

Hwai-Wen Chang ◽

Bertram L. Jacobs

Keyword(s):

Protein Kinase ◽

Vaccinia Virus ◽

Rna Binding ◽

Binding Protein ◽

Rna Binding Protein ◽

Double Stranded Rna ◽

Distinctive Roles for 2′,5′-Oligoadenylate Synthetases and Double-Stranded RNA-Dependent Protein Kinase R in the In Vivo Antiviral Effect of an Adenoviral Vector Expressing Murine IFN-β

The Journal of Immunology ◽

10.4049/jimmunol.172.9.5638 ◽

2004 ◽

Vol 172 (9) ◽

pp. 5638-5647 ◽

Cited By ~ 15

Author(s):

Khaldun Al-khatib ◽

Bryan R. G. Williams ◽

Robert H. Silverman ◽

William Halford ◽

Daniel J. J. Carr

Keyword(s):

Protein Kinase ◽

Adenoviral Vector ◽

Antiviral Effect ◽

Protein Kinase R ◽

Double Stranded Rna ◽

The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.89.11.4825 ◽

1992 ◽

Vol 89 (11) ◽

pp. 4825-4829 ◽

Cited By ~ 307

Author(s):

H. W. Chang ◽

J. C. Watson ◽

B. L. Jacobs

Keyword(s):

Protein Kinase ◽

Vaccinia Virus ◽

Double Stranded Rna ◽

The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms.

Journal of Virology ◽

10.1128/jvi.67.3.1688-1692.1993 ◽

1993 ◽

Vol 67 (3) ◽

pp. 1688-1692 ◽

Cited By ~ 176

Author(s):

M V Davies ◽

H W Chang ◽

B L Jacobs ◽

R J Kaufman

Keyword(s):

Protein Kinase ◽

Vaccinia Virus ◽

Gene Products ◽

Double Stranded Rna ◽

Virus Gene ◽

Faculty Opinions recommendation of Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.2239956.2692064 ◽

2010 ◽

Author(s):

Nancy Sawtell ◽

Diana Koch

Keyword(s):

Protein Kinase ◽

Metabolic Homeostasis ◽

Double Stranded Rna ◽

Faculty Opinions recommendation of Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.2239956.1856054 ◽

2010 ◽

Author(s):

Adolfo Garcia-Sastre

Keyword(s):

Protein Kinase ◽

Metabolic Homeostasis ◽

Double Stranded Rna ◽

Phosphorylation of Plant Eukaryotic Initiation Factor-2 by the Plant-encoded Double-stranded RNA-dependent Protein Kinase, pPKR, and Inhibition of Protein Synthesisin Vitro

Journal of Biological Chemistry ◽

10.1074/jbc.271.8.4539 ◽

1996 ◽

Vol 271 (8) ◽

pp. 4539-4544 ◽

Cited By ~ 41

Author(s):

Jeffrey O. Langland ◽

Lisa A. Langland ◽

Karen S. Browning ◽

Don A. Roth

Keyword(s):

Protein Kinase ◽

Initiation Factor ◽

Eukaryotic Initiation Factor ◽

Double Stranded Rna ◽

Eukaryotic Initiation Factor 2 ◽

Initiation Factor 2 ◽

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.

The EMBO Journal ◽

10.1002/j.1460-2075.1995.tb00300.x ◽

1995 ◽

Vol 14 (24) ◽

pp. 6095-6106 ◽

Cited By ~ 508

Author(s):

Y. L. Yang ◽

L. F. Reis ◽

J. Pavlovic ◽

A. Aguzzi ◽

R. Schäfer ◽

...

Keyword(s):

Protein Kinase ◽

Double Stranded Rna ◽