scholarly journals p73β Is Regulated by Protein Kinase Cδ Catalytic Fragment Generated in the Apoptotic Response to DNA Damage

2002 ◽  
Vol 277 (37) ◽  
pp. 33758-33765 ◽  
Author(s):  
Jian Ren ◽  
Rakesh Datta ◽  
Hisashi Shioya ◽  
Yongqing Li ◽  
Eiji Oki ◽  
...  
Keyword(s):  
Dna Damage ◽  
Protein Kinase ◽  
Apoptotic Response ◽  
Catalytic Fragment ◽  
Protein Kinase Cδ

scholarly journals Activation of SAPK/JNK Signaling by Protein Kinase Cδ in Response to DNA Damage

2002 ◽  
Vol 277 (50) ◽  
pp. 48372-48378 ◽  
Author(s):  
Kiyotsugu Yoshida ◽  
Yoshio Miki ◽  
Donald Kufe
Keyword(s):  
Dna Damage ◽  
Protein Kinase ◽  
Jnk Signaling ◽  
Protein Kinase Cδ

scholarly journals Protein kinase Cδ regulates vaccinia-related kinase 1 in DNA damage–induced apoptosis

2011 ◽  
Vol 22 (8) ◽  
pp. 1398-1408 ◽  
Author(s):  
Choon-Ho Park ◽  
Bo-Hwa Choi ◽  
Min-Woo Jeong ◽  
Sangjune Kim ◽  
Wanil Kim ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cell Death ◽  
Protein Kinase ◽  
Cell Viability ◽  
Apoptotic Cell ◽  
Critical Role ◽  
Regulatory Region ◽  
Dependent Manner ◽  
Protein Kinase Cδ

Vaccinia-related kinase 1 (VRK1) is a novel serine/threonine kinase that plays an important role in cell proliferation. However, little is known about the upstream regulators of VRK1 activity. Here we provide evidence for a role of protein kinase Cδ (PKCδ) in the regulation of murine VRK1. We show that PKCδ interacts with VRK1, phosphorylates the Ser-355 residue in the putative regulatory region, and negatively regulates its kinase activity in vitro. Intriguingly, PKCδ-induced cell death was facilitated by phosphorylation of VRK1 when cells were exposed to a DNA-damaging agent. In addition, p53 played a critical role in the regulation of DNA damage–induced cell death accompanied by PKCδ-mediated modulation of VRK1. In p53-deficient cells, PKCδ-mediated phosphorylation of VRK1 had no effect on cell viability. However, cells overexpressing p53 exhibited significant reduction of cell viability when cotransfected with both VRK1 and PKCδ. Taken together, these results indicate that PKCδ regulates phosphorylation and down-regulation of VRK1, thereby contributing to cell cycle arrest and apoptotic cell death in a p53-dependent manner.

scholarly journals The Protein Kinase Cδ Catalytic Fragment Targets Mcl-1 for Degradation to Trigger Apoptosis

2006 ◽  
Vol 281 (40) ◽  
pp. 29703-29710 ◽  
Author(s):  
Leonid A. Sitailo ◽  
Shalini S. Tibudan ◽  
Mitchell F. Denning
Keyword(s):  
Protein Kinase ◽  
Catalytic Fragment ◽  
Protein Kinase Cδ
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