scholarly journals Kinetics of Amyloid β-Protein Degradation Determined by Novel Fluorescence- and Fluorescence Polarization-based Assays

2003 ◽  
Vol 278 (39) ◽  
pp. 37314-37320 ◽  
Author(s):  
Malcolm A. Leissring ◽  
Alice Lu ◽  
Margaret M. Condron ◽  
David B. Teplow ◽  
Ross L. Stein ◽  
...  
Keyword(s):  
Protein Degradation ◽  
Fluorescence Polarization ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Kinetics Of

Kinetics of secretion of amyloid β-protein and secreted APP

1994 ◽  
Vol 19 ◽  
pp. S169
Author(s):  
Wataru Araki ◽  
Kunishita Tatsuhide ◽  
Tabira Takeshi
Keyword(s):  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Kinetics Of

scholarly journals Early and Selective Impairments in Axonal Transport Kinetics of Synaptic Cargoes Induced by Soluble Amyloid β-Protein Oligomers

Traffic ◽  
2012 ◽  
Vol 13 (5) ◽  
pp. 681-693 ◽  
Author(s):  
Yong Tang ◽  
David A. Scott ◽  
Utpal Das ◽  
Steven D. Edland ◽  
Kryslaine Radomski ◽  
...  
Keyword(s):  
Axonal Transport ◽  
Amyloid Β ◽  
Transport Kinetics ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Kinetics Of

Kinetics of peptide secondary structure conversion during amyloid β-protein fibrillogenesis

2012 ◽  
Vol 301 ◽  
pp. 95-102 ◽  
Author(s):  
Timothy Steckmann ◽  
Zubair Awan ◽  
Bernard S. Gerstman ◽  
Prem P. Chapagain
Keyword(s):  
Secondary Structure ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Peptide Secondary Structure ◽  
Kinetics Of

scholarly journals Dual Effect of Thioflavin T on the Nucleation Kinetics of Amyloid β-Protein 40

2016 ◽  
Vol 32 (6) ◽  
pp. 1391-1396 ◽  
Author(s):  
Song LI ◽  
◽  
Fu-Feng LIU ◽  
Lin-Ling YU ◽  
Yan-Jiao ZHAO ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Thioflavin T ◽  
Amyloid Β Protein ◽  
Nucleation Kinetics ◽  
Dual Effect ◽  
Β Protein ◽  
Kinetics Of

Ketamine reduces amyloid β-protein degradation by suppressing neprilysin expression in primary cultured astrocytes

2013 ◽  
Vol 545 ◽  
pp. 54-58 ◽  
Author(s):  
Naoki Yamamoto ◽  
Hajime Arima ◽  
Kaori Naruse ◽  
Rika Kasahara ◽  
Hideo Taniura ◽  
...  
Keyword(s):  
Protein Degradation ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Cultured Astrocytes ◽  
Primary Cultured Astrocytes

scholarly journals Catalytic photooxygenation degrades brain Aβ in vivo

2021 ◽  
Vol 7 (13) ◽  
pp. eabc9750
Author(s):  
Nozomu Nagashima ◽  
Shuta Ozawa ◽  
Masahiro Furuta ◽  
Miku Oi ◽  
Yukiko Hori ◽  
...  
Keyword(s):  
Protein Degradation ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Protein Targets ◽  
Β Protein ◽  
Endogenous Protein ◽  
Ubiquitin Proteasome ◽  
Related Proteins ◽  
Orange Color

Protein degradation induced by small molecules by recruiting endogenous protein degradation systems, such as ubiquitin-proteasome systems, to disease-related proteins is an emerging concept to inhibit the function of undruggable proteins. Protein targets without reliable ligands and/or existing outside the cells where ubiquitin-proteasome systems do not exist, however, are beyond the scope of currently available protein degradation strategies. Here, we disclose photooxygenation catalyst 7 that permeates the blood-brain barrier and selectively and directly degrades an extracellular Alzheimer’s disease–related undruggable protein, amyloid-β protein (Aβ). Key was the identification of a compact but orange color visible light–activatable chemical catalyst whose activity can be switched on/off according to its molecular mobility, thereby ensuring high selectivity for aggregated Aβ. Chemical catalyst–promoted protein degradation can be applied universally for attenuating extracellular amyloids and various pathogenic proteins and is thus a new entry to induced protein degradation strategies.

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