Telenzepine, a New M1-Receptor Antagonist, Is a More Potent Inhibitor of Pentagastrin-Stimulated Gastric Acid Output Than Pirenzepine in Dogs

1990 ◽  
Vol 25 (3) ◽  
pp. 293-297 ◽  
Author(s):  
G. Holtmann ◽  
U. Küppers ◽  
M. V. Singer
Keyword(s):  
Receptor Antagonist ◽  
Gastric Acid ◽  
Potent Inhibitor ◽  
Acid Output ◽  
Gastric Acid Output ◽  
M1 Receptor

Pharmacological evidence for histamine H3 receptor in the control of gastric acid secretion in cats

1991 ◽  
Vol 260 (4) ◽  
pp. G631-G635 ◽  
Author(s):  
A. Bado ◽  
F. Hervatin ◽  
M. J. Lewin
Keyword(s):  
Acid Secretion ◽  
Receptor Antagonist ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Acid Output ◽  
Gastric Fistula ◽  
Gastric Acid Output ◽  
H2 Receptor Antagonist ◽  
H2 Receptor ◽  
H3 Receptor

We investigated the possible involvement of H3 receptor in the control of gastric acid secretion in the conscious cat provided with a gastric fistula [main stomach (MS)] and a denervated Heidenhain pouch (HP). Intravenous infusion of the selective H3 agonist (R)-alpha-methylhistamine at 3, 10, and 30 nmol.kg-1.h-1 induced a dose-related inhibition of pentagastrin-stimulated gastric acid output. Maximal inhibition in MS (48 +/- 3%, P less than 0.01) and HP (36 +/- 5%, P less than 0.01) was obtained with 30 nmol.kg-1.h-1. This dose also significantly inhibited peptone meal-induced gastric acid output by 38 +/- 4 and 46 +/- 8% (P less than 0.01) in MS and HP, respectively. These inhibitions were completely prevented by 10 nmol.kg-1.h-1 iv of the selective H3 receptor antagonist thioperamide. On the other hand, (R)-alpha-methylhistamine was without any effect on histamine-stimulated gastric acid output, whereas thioperamide produced a slight but not significant increase of this output in contrast to the H2 receptor antagonist ranitidine, which showed a strong inhibitory effect. These findings suggest that pentagastrin- or meal-induced gastric acid secretion involves an H3 receptor pharmacologically distinct from the H2 receptor.

Modulation of gastric acid secretion by adenosine in conscious rats

1987 ◽  
Vol 65 (6) ◽  
pp. 1182-1185 ◽  
Author(s):  
G. B. Glavin ◽  
V. S. Westerberg ◽  
J. D. Geiger
Keyword(s):  
Acid Secretion ◽  
Receptor Antagonist ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Adenosine Receptor ◽  
Acid Output ◽  
Gastric Acid Output ◽  
Gastric Function ◽  
Conscious Rats ◽  
Adenosine Receptor Antagonist

Basal (nonstimulated) gastric acid output was determined in conscious rats fitted with indwelling gastric cannulae. The adenosine deaminase resistant analog of adenosine, R-phenylisopropyladenosine, elevated intraluminal pH beyond 7.0 and decreased gastric acid secretion when given at doses of 0.10 or 1.0 mg/kg, while S-phenylisopropyladenosine at similar doses did not affect either gastric acid output or pH. The potent adenosine receptor antagonist, 8-phenyltheophylline, given at doses of 0.1, 1.0, and 2.5 mg/kg augmented gastric acid output and, at doses of 0.01, 0.1,1.0, and 2.5 mg/kg, blocked the acid-reducing effect of R-phenylisopropyladenosine (0.1 mg/kg). These data suggest that adenosine systems may be important regulators of gastric function.

scholarly journals PAC1 Deficiency in a Murine Model Induces Gastric Mucosa Hypertrophy and Higher Basal Gastric Acid Output

2010 ◽  
Vol 43 (1) ◽  
pp. 76-84 ◽  
Author(s):  
Yuxin Lu ◽  
Patrizia Germano ◽  
Gordon V. Ohning ◽  
John P. Vu ◽  
Joseph R. Pisegna
Keyword(s):  
Gastric Mucosa ◽  
Gastric Acid ◽  
Murine Model ◽  
Acid Output ◽  
Gastric Acid Output

Effect of vagotomy on the acid response to gastric distension

1970 ◽  
Vol 48 (10) ◽  
pp. 670-674 ◽  
Author(s):  
R. M. Preshaw
Keyword(s):  
Motor Activity ◽  
Gastric Acid ◽  
Motor Response ◽  
Acid Output ◽  
The Body ◽  
Conscious Dogs ◽  
Truncal Vagotomy ◽  
Gastric Distension ◽  
Gastric Acid Output

Distension of the body of the stomach, in conscious dogs with vagally innervated antral pouches, caused an increase in gastric acid output, and an increase in antral motor activity. Truncal vagotomy inhibited the acid response to distension, but had no effect on the antral motor response. Denervation of the antral pouch by separating it from the main stomach caused little further diminution in the response.

scholarly journals A new method for determining gastric acid output using a wireless pH-sensing capsule

2013 ◽  
Vol 37 (12) ◽  
pp. 1198-1209 ◽  
Author(s):  
D. H. Weinstein ◽  
S. deRijke ◽  
C. C. Chow ◽  
L. Foruraghi ◽  
X. Zhao ◽  
...  
Keyword(s):  
Gastric Acid ◽  
Acid Output ◽  
New Method ◽  
Ph Sensing ◽  
Gastric Acid Output
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