Decreased Gastric Acid Output Following Neuropeptide Y Administration into the Lateral Cerebral Ventricle of Conscious Rats

Injection of neuropeptide Y (NPY) into the hypothalamic paraventricular nucleus (PVN) inhibits gastric acid secretion in anesthetized rats. The role of the autonomic nervous system in mediation of this response was investigated. Unilateral microinjection of 200 pmol NPY into the PVN of anesthetized rats inhibited spontaneous and pentagastrin-stimulated gastric acid output. Inhibition was abolished by subdiaphragmatic vagotomy, atropine, and bethanechol but was restored by electrical stimulation of the distal cut end of the vagus in cervically vagotomized rats. Although sympathectomy, phenoxybenzamine, and yohimbine abolished the inhibition, it was not affected by prazosin treatment. Gastric blood flow was not altered by injection of NPY. These results suggest that the antisecretory effect of NPY in the PVN was sympathetically mediated via suppression of gastric vagal cholinergic tone through activation of alpha 2-adrenoceptors.

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Modulation of gastric acid secretion by adenosine in conscious rats

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y87-186 ◽

1987 ◽

Vol 65 (6) ◽

pp. 1182-1185 ◽

Cited By ~ 11

Author(s):

G. B. Glavin ◽

V. S. Westerberg ◽

J. D. Geiger

Keyword(s):

Acid Secretion ◽

Receptor Antagonist ◽

Gastric Acid Secretion ◽

Gastric Acid ◽

Adenosine Receptor ◽

Acid Output ◽

Gastric Acid Output ◽

Gastric Function ◽

Conscious Rats ◽

Adenosine Receptor Antagonist

Basal (nonstimulated) gastric acid output was determined in conscious rats fitted with indwelling gastric cannulae. The adenosine deaminase resistant analog of adenosine, R-phenylisopropyladenosine, elevated intraluminal pH beyond 7.0 and decreased gastric acid secretion when given at doses of 0.10 or 1.0 mg/kg, while S-phenylisopropyladenosine at similar doses did not affect either gastric acid output or pH. The potent adenosine receptor antagonist, 8-phenyltheophylline, given at doses of 0.1, 1.0, and 2.5 mg/kg augmented gastric acid output and, at doses of 0.01, 0.1,1.0, and 2.5 mg/kg, blocked the acid-reducing effect of R-phenylisopropyladenosine (0.1 mg/kg). These data suggest that adenosine systems may be important regulators of gastric function.

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Sexual arousal increases gastric acid output

Gastroenterology ◽

10.1016/0016-5085(78)93254-7 ◽

1978 ◽

Vol 74 (5) ◽

pp. 1066

Author(s):

J.C. Meeroff

Keyword(s):

Gastric Acid ◽

Sexual Arousal ◽

Acid Output ◽

Gastric Acid Output

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PAC1 Deficiency in a Murine Model Induces Gastric Mucosa Hypertrophy and Higher Basal Gastric Acid Output

Journal of Molecular Neuroscience ◽

10.1007/s12031-010-9440-z ◽

2010 ◽

Vol 43 (1) ◽

pp. 76-84 ◽

Cited By ~ 11

Author(s):

Yuxin Lu ◽

Patrizia Germano ◽

Gordon V. Ohning ◽

John P. Vu ◽

Joseph R. Pisegna

Keyword(s):

Gastric Mucosa ◽

Gastric Acid ◽

Murine Model ◽

Acid Output ◽

Gastric Acid Output

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The Effect of Intragastric Ammonia Production on Titratable Gastric Acid Output in Helicobacter pylori-Infected Patients with Chronic Gastritis

Digestive Diseases and Sciences ◽

10.1007/s10620-005-3013-y ◽

2005 ◽

Vol 50 (11) ◽

pp. 2094-2099 ◽

Cited By ~ 4

Author(s):

Bogdan Cylwik ◽

Jan W. Dlugosz ◽

Andrzej Kemona ◽

Maciej Szmitkowski

Keyword(s):

Helicobacter Pylori ◽

Gastric Acid ◽

Chronic Gastritis ◽

Acid Output ◽

Ammonia Production ◽

Gastric Acid Output

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Effect of vagotomy on the acid response to gastric distension

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y70-098 ◽

1970 ◽

Vol 48 (10) ◽

pp. 670-674 ◽

Cited By ~ 4

Author(s):

R. M. Preshaw

Keyword(s):

Motor Activity ◽

Gastric Acid ◽

Motor Response ◽

Acid Output ◽

The Body ◽

Conscious Dogs ◽

Truncal Vagotomy ◽

Gastric Distension ◽

Gastric Acid Output

Distension of the body of the stomach, in conscious dogs with vagally innervated antral pouches, caused an increase in gastric acid output, and an increase in antral motor activity. Truncal vagotomy inhibited the acid response to distension, but had no effect on the antral motor response. Denervation of the antral pouch by separating it from the main stomach caused little further diminution in the response.

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