A convenient and practical synthesis of the cis isomer of the first orally active dopamine D3-Preferring D3-D2 receptor partial agonist cariprazine

2021 ◽  
pp. 1-8
Author(s):  
Rui-Xiang Yuan ◽  
Jun-Wei Xu ◽  
Lian-Hua Song ◽  
Yang-Li Qi ◽  
Hong Mou ◽  
...  
Keyword(s):  
Partial Agonist ◽  
D2 Receptor ◽  
Dopamine D3 ◽  
Practical Synthesis ◽  
Orally Active ◽  
Cis Isomer

DOPAMINE D3 RECEPTOR OCCUPANCY AND D3 RECEPTOR-MEDIATED ACTIONS OF CARIPRAZINE, A DOPAMINE D3/D2 RECEPTOR PARTIAL AGONIST ANTIPSYCHOTIC CANDIDATE

2014 ◽  
Vol 153 ◽  
pp. S23
Author(s):  
Ashok Rakhit ◽  
Suresh Durgam ◽  
Nika Adham ◽  
István Gyertyán ◽  
Béla Kiss ◽  
...  
Keyword(s):  
Partial Agonist ◽  
D2 Receptor ◽  
Receptor Occupancy ◽  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Dopamine D3

Cariprazine (RGH-188), a D3-preferring dopamine D3/D2 receptor partial agonist antipsychotic candidate demonstrates anti-abuse potential in rats

2012 ◽  
Vol 226 (2) ◽  
pp. 285-293 ◽  
Author(s):  
V. Román ◽  
I. Gyertyán ◽  
K. Sághy ◽  
B. Kiss ◽  
Zs. Szombathelyi
Keyword(s):  
Partial Agonist ◽  
D2 Receptor ◽  
Abuse Potential ◽  
Dopamine D3

Pharmacology of human dopamine D3 receptor expressed in a mammalian cell line: comparison with D2 receptor

1992 ◽  
Vol 225 (4) ◽  
pp. 331-337 ◽  
Author(s):  
Pierre Sokoloff ◽  
Marc Andrieux ◽  
Roger Besançon ◽  
Catherine Pilon ◽  
Marie-Pascale Martres ◽  
...  
Keyword(s):  
Cell Line ◽  
Mammalian Cell ◽  
D2 Receptor ◽  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Mammalian Cell Line ◽  
Dopamine D3

Characterization of aripiprazole partial agonist activity at human dopamine D3 receptors

2008 ◽  
Vol 597 (1-3) ◽  
pp. 27-33 ◽  
Author(s):  
Yoshihiro Tadori ◽  
Robert A. Forbes ◽  
Robert D. McQuade ◽  
Tetsuro Kikuchi
Keyword(s):  
Partial Agonist ◽  
Agonist Activity ◽  
Dopamine D3 Receptors ◽  
D3 Receptors ◽  
Partial Agonist Activity ◽  
Dopamine D3

RETRACTED: Dopamine D3 receptor partial agonist LS-3-134 attenuates cocaine-motivated behaviors

2018 ◽  
Vol 171 ◽  
pp. 46-53 ◽  
Author(s):  
Gregory L. Powell ◽  
John Paul Bonadonna ◽  
Annika Vannan ◽  
Kuiying Xu ◽  
Robert H. Mach ◽  
...  
Keyword(s):  
Partial Agonist ◽  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Dopamine D3 ◽  
Motivated Behaviors
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