Approach to the prediction of the contribution of major cytochrome P450 enzymes to drug metabolism in the early drug-discovery stage

Xenobiotica ◽  
2006 ◽  
Vol 36 (8) ◽  
pp. 671-683 ◽  
Author(s):  
C. Emoto ◽  
S. Murase ◽  
K. Iwasaki
Keyword(s):  
Cytochrome P450 ◽  
Drug Discovery ◽  
Drug Metabolism ◽  
Cytochrome P450 Enzymes ◽  
Discovery Stage ◽  
Early Drug

Proposal of a Parameter for OATP1B1 Inhibition Screening at the Early Drug Discovery Stage

2019 ◽  
Vol 108 (12) ◽  
pp. 3898-3902 ◽  
Author(s):  
Hiroyuki Murata ◽  
Soichiro Ito ◽  
Hiroyuki Kusuhara ◽  
Yukihiro Nomura ◽  
Toshio Taniguchi
Keyword(s):  
Drug Discovery ◽  
Discovery Stage ◽  
Early Drug

Software-aided cytochrome P450 reaction phenotyping and kinetic analysis in early drug discovery

2015 ◽  
Vol 30 (2) ◽  
pp. 301-310 ◽  
Author(s):  
Esra Nurten Cece-Esencan ◽  
Fabien Fontaine ◽  
Guillem Plasencia ◽  
Marieke Teppner ◽  
Andreas Brink ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Discovery ◽  
Kinetic Analysis ◽  
Reaction Phenotyping ◽  
Early Drug

scholarly journals Drug Metabolism by Cytochrome P450 Enzymes: What Distinguishes the Pathways Leading to Substrate Hydroxylation Over Desaturation?

2015 ◽  
Vol 21 (25) ◽  
pp. 8973-8973 ◽  
Author(s):  
Li Ji ◽  
Abayomi S. Faponle ◽  
Matthew G. Quesne ◽  
Mala A. Sainna ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Cytochrome P450 Enzymes ◽  
Substrate Hydroxylation

scholarly journals Effects of Ospemifene on Drug Metabolism Mediated by Cytochrome P450 Enzymes in Humans in Vitro and in Vivo

2013 ◽  
Vol 14 (7) ◽  
pp. 14064-14075 ◽  
Author(s):  
Miia Turpeinen ◽  
Jouko Uusitalo ◽  
Terhi Lehtinen ◽  
Marita Kailajärvi ◽  
Olavi Pelkonen ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Cytochrome P450 Enzymes
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