Utility of Recombinant Cytochrome P450 Enzymes: A Drug Metabolism Perspective

2005 ◽  
Vol 6 (5) ◽  
pp. 503-517 ◽  
Author(s):  
W. Tang ◽  
R. Wang ◽  
Anthony Lu
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Cytochrome P450 Enzymes

scholarly journals Drug Metabolism by Cytochrome P450 Enzymes: What Distinguishes the Pathways Leading to Substrate Hydroxylation Over Desaturation?

2015 ◽  
Vol 21 (25) ◽  
pp. 8973-8973 ◽  
Author(s):  
Li Ji ◽  
Abayomi S. Faponle ◽  
Matthew G. Quesne ◽  
Mala A. Sainna ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Cytochrome P450 Enzymes ◽  
Substrate Hydroxylation

scholarly journals Effects of Ospemifene on Drug Metabolism Mediated by Cytochrome P450 Enzymes in Humans in Vitro and in Vivo

2013 ◽  
Vol 14 (7) ◽  
pp. 14064-14075 ◽  
Author(s):  
Miia Turpeinen ◽  
Jouko Uusitalo ◽  
Terhi Lehtinen ◽  
Marita Kailajärvi ◽  
Olavi Pelkonen ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Cytochrome P450 Enzymes

scholarly journals Cytochrome P450 enzymes: understanding the biochemical hieroglyphs

F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 178 ◽  
Author(s):  
John T. Groves
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Reactive Intermediates ◽  
Heme Iron ◽  
Cytochrome P450 Enzymes ◽  
Steroid Biosynthesis ◽  
Reaction Cycle ◽  
Cyp Enzymes ◽  
Protein Architecture ◽  
Recent Advances

Cytochrome P450 (CYP) enzymes are the primary proteins of drug metabolism and steroid biosynthesis. These crucial proteins have long been known to harbor a cysteine thiolate bound to the heme iron. Recent advances in the field have illuminated the nature of reactive intermediates in the reaction cycle. Similar intermediates have been observed and characterized in novel heme-thiolate proteins of fungal origin. Insights from these discoveries have begun to solve the riddle of how enzyme biocatalyst design can afford a protein that can transform substrates that are more difficult to oxidize than the surrounding protein architecture.

Drug Metabolism by Cytochrome P450 Enzymes: What Distinguishes the Pathways Leading to Substrate Hydroxylation Over Desaturation?

2015 ◽  
Vol 21 (25) ◽  
pp. 9083-9092 ◽  
Author(s):  
Li Ji ◽  
Abayomi S. Faponle ◽  
Matthew G. Quesne ◽  
Mala A. Sainna ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Cytochrome P450 Enzymes ◽  
Substrate Hydroxylation
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