Fabrication and characterization of dual drug-loaded poly (lactic-co-glycolic acid) fiber-microsphere composite scaffolds

2018 ◽  
Vol 68 (7) ◽  
pp. 375-383 ◽  
Author(s):  
Wen Zhao ◽  
Wenlong Liu ◽  
Rui Xu ◽  
Yian Wang ◽  
Kaixiang Jin ◽  
...  
2021 ◽  
Vol 8 ◽  
Author(s):  
Fujian Zhao ◽  
Xiongfa Ji ◽  
Yang Yan ◽  
Zhen Yang ◽  
Xiaofeng Chen ◽  
...  

The repair of bone defects in load-bearing positions still faces great challenges. Tantalum (Ta) has attempted to repair bone defects based on the excellent mechanical properties. However, the osseointegration of Ta needs to be improved due to the lack of osteoinduction. Herein, tantalum–gelatin–methacryloyl–bioactive glass (Ta–GelMA–BG) scaffolds were successfully fabricated by loading BG in 3D-printed Ta scaffolds through a chemical crosslinking method. The results showed that the composite scaffolds have the ability to promote cell adhesion and proliferation. The incorporation of BG resulted in a significant increase in apatite-forming and osteogenesis differentiation abilities. In vivo results indicated that the Ta–GelMA–BG scaffolds significantly enhanced the osteointegration at the early stage after implantation. Overall, the Ta–GelMA–BG scaffolds are a promising platform for the load bearing bone regeneration field.


2012 ◽  
Vol 66 (1) ◽  
pp. 36-38 ◽  
Author(s):  
Hairong Liu ◽  
Leilei Xia ◽  
Yao Dai ◽  
Man Zhao ◽  
Zheng Zhou ◽  
...  

2016 ◽  
Vol 56 (9) ◽  
pp. 983-991 ◽  
Author(s):  
Anuj Kumar ◽  
Kummara Madhusudana Rao ◽  
Adnan Haider ◽  
Sung Soo Han ◽  
Tae Won Son ◽  
...  

Heliyon ◽  
2020 ◽  
Vol 6 (5) ◽  
pp. e03975
Author(s):  
Shifteh Malekhosseini ◽  
Aram Rezaie ◽  
Salar Khaledian ◽  
Mohadese Abdoli ◽  
Mohammad Mahdi Zangeneh ◽  
...  

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