Fabrication and Characterization of Polymer and Composite Scaffolds Using Freeze-Drying Technique

2014 ◽  
pp. 45-60
Author(s):  
Naznin Sultana ◽  
Mohd Izzat Hassan ◽  
Mim Mim Lim
Keyword(s):  
Freeze Drying ◽  
Composite Scaffolds ◽  
Fabrication And Characterization

Fabrication and Characterisation of Polymer and Composite Scaffolds Based on Polyhydroxybutyrate and Polyhydroxybutyrate-Co-Hydroxyvalerate

2007 ◽  
Vol 334-335 ◽  
pp. 1229-1232 ◽  
Author(s):  
Naznin Sultana ◽  
Min Wang
Keyword(s):  
Freeze Drying ◽  
Polymer Concentration ◽  
Three Dimensional ◽  
Polymer Scaffolds ◽  
Composite Scaffolds ◽  
Fabrication And Characterization ◽  
Fabrication Parameters ◽  
Highly Porous ◽  
Interconnected Pores

This paper reports the fabrication and characterization of three-dimensional, highly porous polyhydroxybutyrate (PHB), polyhydroxybutyrate-co-valerate (PHBV) and composite scaffolds made by the emulsion freezing / freezing-drying technique. Freeze-drying of the polymer/solvent/ water phase emulsions produced hard and tough scaffolds with interconnected pores. The effects of the fabrication parameters such as polymer concentration in emulsions and emulsion stabilizer were examined and optimized. The density of polymer scaffolds was found to increase with an increasing polymer concentration. Structural analyses of selected samples using scanning electron microscopy indicated that the scaffolds had pore sizes ranging from several microns to a few hundred microns. The porosity of scaffolds of up to 85% was achieved and it increased with a decreasing polymer concentration. It was found that mechanical properties of composite scaffolds increased with the increasing amount of hydroxyapatite (HA) incorporated in the scaffolds.

Preparation and Characterization of Chitosan-Based Scaffolds for Biomedical Applications

2006 ◽  
Vol 514-516 ◽  
pp. 1005-1009 ◽  
Author(s):  
José V. Araújo ◽  
J.A. Lopes da Silva ◽  
Margarida M. Almeida ◽  
Maria Elisabete V. Costa
Keyword(s):  
Biomedical Applications ◽  
Freeze Drying ◽  
Average Pore Size ◽  
Composite Scaffolds ◽  
Average Pore ◽  
Chitosan Matrix ◽  
Freeze Dried ◽  
Porous Chitosan ◽  
Interconnected Structure

Porous chitosan/brushite composite scaffolds were prepared by a freeze-drying technique, starting from brushite suspensions in chitosan solutions. The obtained scaffolds showed a regular macroporous and interconnected structure with brushite particles uniformly distributed in the chitosan matrix. The variation of the brushite concentration affected the microstructure of the final freeze-dried scaffold, in particular, its porosity and its average pore size. The yield strengths of the composite scaffolds could also be improved by the increase of the brushite content.

scholarly journals Fabrication and Characterization of Ta–GelMA–BG Scaffolds by Chemical Crosslinking Processing for Promotion Osteointegration

2021 ◽  
Vol 8 ◽  
Author(s):  
Fujian Zhao ◽  
Xiongfa Ji ◽  
Yang Yan ◽  
Zhen Yang ◽  
Xiaofeng Chen ◽  
...  
Keyword(s):  
Early Stage ◽  
Bone Defects ◽  
Chemical Crosslinking ◽  
Composite Scaffolds ◽  
Load Bearing ◽  
3D Printed ◽  
Fabrication And Characterization ◽  
Cell Adhesion And Proliferation

The repair of bone defects in load-bearing positions still faces great challenges. Tantalum (Ta) has attempted to repair bone defects based on the excellent mechanical properties. However, the osseointegration of Ta needs to be improved due to the lack of osteoinduction. Herein, tantalum–gelatin–methacryloyl–bioactive glass (Ta–GelMA–BG) scaffolds were successfully fabricated by loading BG in 3D-printed Ta scaffolds through a chemical crosslinking method. The results showed that the composite scaffolds have the ability to promote cell adhesion and proliferation. The incorporation of BG resulted in a significant increase in apatite-forming and osteogenesis differentiation abilities. In vivo results indicated that the Ta–GelMA–BG scaffolds significantly enhanced the osteointegration at the early stage after implantation. Overall, the Ta–GelMA–BG scaffolds are a promising platform for the load bearing bone regeneration field.

Fabrication and characterization of novel hydroxyapatite/porous carbon composite scaffolds

2012 ◽  
Vol 66 (1) ◽  
pp. 36-38 ◽  
Author(s):  
Hairong Liu ◽  
Leilei Xia ◽  
Yao Dai ◽  
Man Zhao ◽  
Zheng Zhou ◽  
...  
Keyword(s):  
Porous Carbon ◽  
Carbon Composite ◽  
Composite Scaffolds ◽  
Fabrication And Characterization

Fabrication and Characterization of Multicomponent Polysaccharide/Nanohydroxyapatite Composite Scaffolds

2016 ◽  
Vol 56 (9) ◽  
pp. 983-991 ◽  
Author(s):  
Anuj Kumar ◽  
Kummara Madhusudana Rao ◽  
Adnan Haider ◽  
Sung Soo Han ◽  
Tae Won Son ◽  
...  
Keyword(s):  
Composite Scaffolds ◽  
Fabrication And Characterization

Fabrication and characterization of silk fibroin/chitosan/Nano γ-alumina composite scaffolds for tissue engineering applications

RSC Advances ◽  
2015 ◽  
Vol 5 (35) ◽  
pp. 27558-27570 ◽  
Author(s):  
Abbas Teimouri ◽  
Raheleh Ebrahimi ◽  
Alireza Najafi Chermahini ◽  
Rahmatollah Emadi
Keyword(s):  
Tissue Engineering ◽  
Silk Fibroin ◽  
Composite Scaffolds ◽  
Engineering Applications ◽  
Alumina Composite ◽  
Fabrication And Characterization

A series of silk fibroin/chitosan/Nano γ-alumina composite scaffolds have been prepared using the lyophilization technique for tissue engineering. These were then characterized using SEM, XRD, EDX, FTIR and TGA.

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