Antibacterial combination therapy using Co3+, Cu2+, Zn2+ and Pd2+ complexes: Their calf thymus DNA binding studies

Background: In this era of science, cancer is a black dot on the face of humankind. Consequently, the search of promising anticancer agents continues. Aims: Here we designed and synthesized new N-substituted rhodanines (RD1-7), evaluated their multispectroscopic interaction with calf thymus DNA, in silico and anticancer studies against MDA-MB-231cancer cell line. Methods: By MTT assay rhodanine RD1 was found to be the most potent with IC50 value of 72.61 μM. In addition, DNA binding studies (UV-vis and fluorescence) revealed strong binding affinity of RD1-7 with DNA (Kb in the range of 1.5-7.4 × 105 M-1). Moreover, molecular docking study, experimental DNA binding and anticancer studies are all well agreed to each other. Results: It was observed that H-bonding and hydrophobic attractions were responsible for stability of DNAcompound adducts. Besides, the reported rhodanines (RD1-7) were found as minor groove binders of DNA. Concisely, RD1-7 indicated promising pharmacological properties and hence, shows auspicious future for the development of novel anticancer agents. Conclusion: The reported rhodanines showed excellent anticancer properties. Therefore, the described rhodanines may be used as potential anticancer agents in the future.

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Calf thymus DNA binding studies of the new neodymium-naproxen complex

Journal of Biochemical and Molecular Toxicology ◽

10.1002/jbt.21401 ◽

2012 ◽

Vol 26 (5) ◽

pp. 193-198 ◽

Cited By ~ 4

Author(s):

Ruina Huo ◽

Guiqing Xu ◽

Xiaoying Jiang ◽

Yao Ge ◽

Zaikun Xue ◽

...

Keyword(s):

Dna Binding ◽

Calf Thymus Dna ◽

Binding Studies ◽

Calf Thymus ◽

Dna Binding Studies

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Towards understanding the mechanism of action of mithramycin and its analogues: dimerization and DNA binding studies

Planta Medica ◽

10.1055/s-0036-1596246 ◽

2016 ◽

Vol 81 (S 01) ◽

pp. S1-S381

Author(s):

S Weidenbach ◽

C Hou ◽

JM Chen ◽

OV Tsodikov ◽

J Rohr

Keyword(s):

Dna Binding ◽

Mechanism Of Action ◽

Binding Studies ◽

Dna Binding Studies

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Metal Based Pharmacological Active Agents: Structural, Electrochemical, DNA Binding Studies and Antibacterial Properties

Current Drug Therapy ◽

10.2174/157488550904150525152329 ◽

2015 ◽

Vol 9 (4) ◽

pp. 210-218 ◽

Cited By ~ 1

Author(s):

Harun Muslu ◽

Derya Kılıcaslan ◽

Mustafa Cesme ◽

Aysegul Golcu ◽

Sibel Ozkan

Keyword(s):

Dna Binding ◽

Antibacterial Properties ◽

Binding Studies ◽

Dna Binding Studies

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BSA and DNA Binding Studies of Aspergillus foetidus Mediated Biosynthesized CdS Nanoparticles

Current Nanoscience ◽

10.2174/1573413712666160630131356 ◽

2016 ◽

Vol 12 (6) ◽

pp. 781-788 ◽

Cited By ~ 1

Author(s):

Tina Nasrin ◽

Ratan Sadhukhan ◽

Tapan Kumar Das

Keyword(s):

Dna Binding ◽

Cds Nanoparticles ◽

Binding Studies ◽

Aspergillus Foetidus ◽

Dna Binding Studies

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Arene ruthenium, rhodium and iridium complexes containing benzamide derivative ligands: Study of interesting bonding modes, antibacterial, antioxidant and DNA binding studies

Journal of Organometallic Chemistry ◽

10.1016/j.jorganchem.2021.121731 ◽

2021 ◽

Vol 937 ◽

pp. 121731

Author(s):

Lathewdeipor Shadap ◽

Nipanshu Agarwal ◽

Vivek Chetry ◽

Krishna Mohan Poluri ◽

Werner Kaminsky ◽

...

Keyword(s):

Dna Binding ◽

Iridium Complexes ◽

Binding Studies ◽

Dna Binding Studies

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DNA-binding studies and antioxidant activities of two-, three- and four-coordinate silver(i) complexes containing bis(2-benzimidazolyl)aniline derivatives

New Journal of Chemistry ◽

10.1039/c4nj00503a ◽

2014 ◽

Vol 38 (8) ◽

pp. 3688-3698 ◽

Cited By ~ 36

Author(s):

Huilu Wu ◽

Yanhui Zhang ◽

Chengyong Chen ◽

Jiawen Zhang ◽

Yuchen Bai ◽

...

Keyword(s):

Dna Binding ◽

Hydroxyl Radical ◽

Superoxide Radical ◽

Antioxidant Activities ◽

Binding Studies ◽

Aniline Derivatives ◽

Novel Structure ◽

Dna Binding Studies

Three novel structure Ag(i) complexes have been synthesized and characterized. The three ligands and Ag(i) complexes bind to DNA in an intercalation mode. The Ag(i) complexes have stronger ability of antioxidation for hydroxyl radical and superoxide radical.

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