Episodic memory reconsolidation: Updating or source confusion?

Memory ◽  
2009 ◽  
Vol 17 (5) ◽  
pp. 502-510 ◽  
Author(s):  
Almut Hupbach ◽  
Rebecca Gomez ◽  
Lynn Nadel
2018 ◽  
Vol 25 (8) ◽  
pp. 369-381 ◽  
Author(s):  
Alyssa H. Sinclair ◽  
Morgan D. Barense

2020 ◽  
Author(s):  
Despina Antypa ◽  
Aurore A. Perrault ◽  
Patrik Vuilleumier ◽  
Sophie Schwartz ◽  
Ulrike Rimmele

AbstractEvidence from animal and human research shows that established memories can undergo changes after reactivation through a process called reconsolidation. Alterations of the level of the stress hormone cortisol may be one way of manipulating reconsolidation. Here, in a double-blind, within-subject design, we reactivated a 3-day-old memory at 3:55 a.m., immediately followed by oral administration of metyrapone vs. placebo, to examine whether metyrapone-induced suppression of the morning cortisol rise may influence reconsolidation processes during and after early morning sleep. Crucially, reactivation followed by cortisol suppression vs. placebo resulted in enhanced memory for the reactivated episode (tested four days after reactivation). This enhancement after cortisol suppression was specific for the reactivated episode vs. a non-reactivated episode. These findings suggest that when reactivation of memories is immediately followed by suppression of cortisol levels during early morning sleep, reconsolidation processes change in a way that leads to the strengthening of episodic memory traces.


2019 ◽  
Vol 5 (3) ◽  
pp. eaav3801 ◽  
Author(s):  
Ana Galarza Vallejo ◽  
Marijn C. W. Kroes ◽  
Enrique Rey ◽  
Maria Victoria Acedo ◽  
Stephan Moratti ◽  
...  

The adjustment of maladaptive thoughts and behaviors associated with emotional memories is central to treating psychiatric disorders. Recent research, predominantly with laboratory animals, indicates that memories can become temporarily sensitive to modification following reactivation, before undergoing reconsolidation. A method to selectively impair reconsolidation of specific emotional or traumatic memories in humans could translate to an effective treatment for conditions such as posttraumatic stress disorder. We tested whether deep sedation could impair emotional memory reconsolidation in 50 human participants. Administering the intravenous anesthetic propofol following memory reactivation disrupted memory for the reactivated, but not for a non-reactivated, slideshow story. Propofol impaired memory for the reactivated story after 24 hours, but not immediately after propofol recovery. Critically, memory impairment occurred selectively for the emotionally negative phase of the reactivated story. One dose of propofol following memory reactivation selectively impaired subsequent emotional episodic memory retrieval in a time-dependent manner, consistent with reconsolidation impairment.


2021 ◽  
pp. JN-RM-0096-21
Author(s):  
Despina Antypa ◽  
Aurore A. Perrault ◽  
Patrik Vuilleumier ◽  
Sophie Schwartz ◽  
Ulrike Rimmele

2021 ◽  
Vol 28 (2) ◽  
pp. 30-33
Author(s):  
Michael Craig ◽  
Christopher Knowles ◽  
Stephanie Hill ◽  
Michaela Dewar

2013 ◽  
pp. 233-247 ◽  
Author(s):  
Almut Hupbach ◽  
Rebecca Gomez ◽  
Lynn Nadel

2017 ◽  
Vol 24 (5) ◽  
pp. 216-224 ◽  
Author(s):  
Angela Klingmüller ◽  
Jeremy B. Caplan ◽  
Tobias Sommer

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