Surprise and destabilize: prediction error influences episodic memory reconsolidation

AbstractEvidence from animal and human research shows that established memories can undergo changes after reactivation through a process called reconsolidation. Alterations of the level of the stress hormone cortisol may be one way of manipulating reconsolidation. Here, in a double-blind, within-subject design, we reactivated a 3-day-old memory at 3:55 a.m., immediately followed by oral administration of metyrapone vs. placebo, to examine whether metyrapone-induced suppression of the morning cortisol rise may influence reconsolidation processes during and after early morning sleep. Crucially, reactivation followed by cortisol suppression vs. placebo resulted in enhanced memory for the reactivated episode (tested four days after reactivation). This enhancement after cortisol suppression was specific for the reactivated episode vs. a non-reactivated episode. These findings suggest that when reactivation of memories is immediately followed by suppression of cortisol levels during early morning sleep, reconsolidation processes change in a way that leads to the strengthening of episodic memory traces.

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Beyond arousal: Prediction error related to aversive events promotes episodic memory formation.

Journal of Experimental Psychology Learning Memory and Cognition ◽

10.1037/xlm0000728 ◽

2020 ◽

Vol 46 (2) ◽

pp. 234-246 ◽

Cited By ~ 3

Author(s):

Felix Kalbe ◽

Lars Schwabe

Keyword(s):

Episodic Memory ◽

Prediction Error ◽

Memory Formation ◽

Aversive Events

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The fate of memory: Reconsolidation and the case of Prediction Error

Neuroscience & Biobehavioral Reviews ◽

10.1016/j.neubiorev.2016.06.004 ◽

2016 ◽

Vol 68 ◽

pp. 423-441 ◽

Cited By ~ 66

Author(s):

Rodrigo S. Fernández ◽

Mariano M. Boccia ◽

María E. Pedreira

Keyword(s):

Prediction Error ◽

Memory Reconsolidation

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Propofol-induced deep sedation reduces emotional episodic memory reconsolidation in humans

Science Advances ◽

10.1126/sciadv.aav3801 ◽

2019 ◽

Vol 5 (3) ◽

pp. eaav3801 ◽

Cited By ~ 7

Author(s):

Ana Galarza Vallejo ◽

Marijn C. W. Kroes ◽

Enrique Rey ◽

Maria Victoria Acedo ◽

Stephan Moratti ◽

...

Keyword(s):

Episodic Memory ◽

Memory Retrieval ◽

Deep Sedation ◽

Emotional Memory ◽

Laboratory Animals ◽

Memory Reconsolidation ◽

Dependent Manner ◽

Memory Reactivation ◽

Traumatic Memories ◽

Human Participants

The adjustment of maladaptive thoughts and behaviors associated with emotional memories is central to treating psychiatric disorders. Recent research, predominantly with laboratory animals, indicates that memories can become temporarily sensitive to modification following reactivation, before undergoing reconsolidation. A method to selectively impair reconsolidation of specific emotional or traumatic memories in humans could translate to an effective treatment for conditions such as posttraumatic stress disorder. We tested whether deep sedation could impair emotional memory reconsolidation in 50 human participants. Administering the intravenous anesthetic propofol following memory reactivation disrupted memory for the reactivated, but not for a non-reactivated, slideshow story. Propofol impaired memory for the reactivated story after 24 hours, but not immediately after propofol recovery. Critically, memory impairment occurred selectively for the emotionally negative phase of the reactivated story. One dose of propofol following memory reactivation selectively impaired subsequent emotional episodic memory retrieval in a time-dependent manner, consistent with reconsolidation impairment.

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Effects of transcranial direct current stimulation over the posterior parietal cortex on episodic memory reconsolidation

Cortex ◽

10.1016/j.cortex.2019.08.009 ◽

2019 ◽

Vol 121 ◽

pp. 78-88 ◽

Cited By ~ 2

Author(s):

Margot Crossman ◽

Gergely Bartl ◽

Rebecca Soerum ◽

Marco Sandrini

Keyword(s):

Episodic Memory ◽

Parietal Cortex ◽

Direct Current ◽

Transcranial Direct Current Stimulation ◽

Posterior Parietal Cortex ◽

Memory Reconsolidation ◽

Direct Current Stimulation ◽

Posterior Parietal

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Prediction Error-Driven Memory Consolidation for Continual Learning: On the Case of Adaptive Greenhouse Models

KI - Künstliche Intelligenz ◽

10.1007/s13218-020-00700-8 ◽

2021 ◽

Author(s):

Guido Schillaci ◽

Uwe Schmidt ◽

Luis Miranda

Keyword(s):

Online Learning ◽

Episodic Memory ◽

Prior Knowledge ◽

Memory Consolidation ◽

Prediction Error ◽

Neural Model ◽

Adaptive Architecture ◽

Brain Sciences ◽

Research Facilities ◽

Continual Learning

AbstractThis work presents an adaptive architecture that performs online learning and faces catastrophic forgetting issues by means of an episodic memory system and of prediction-error driven memory consolidation. In line with evidence from brain sciences, memories are retained depending on their congruence with the prior knowledge stored in the system. In this work, congruence is estimated in terms of prediction error resulting from a deep neural model. The proposed AI system is transferred onto an innovative application in the horticulture industry: the learning and transfer of greenhouse models. This work presents models trained on data recorded from research facilities and transferred to a production greenhouse.

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