Preparation of (R)-(-)-mandelic acid by two-step biotransformation of ethyl benzoylformate

2017 ◽  
Vol 36 (6) ◽  
pp. 409-416 ◽  
Author(s):  
Ou Zhimin ◽  
Lan Ma ◽  
Yangpin Niu ◽  
Jian Cui
Keyword(s):  
Mandelic Acid ◽  
Ethyl Benzoylformate

Synthesis of (R)-(-)-Mandelic Acid Ethyl Ester by Asymmetric Reduction of Ethyl Benzoylformate with Yeast Cells

2012 ◽  
Vol 560-561 ◽  
pp. 273-278
Author(s):  
Zhi Min Ou ◽  
Ying Kang Nan
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Ethyl Ester ◽  
Mandelic Acid ◽  
Cell Concentration ◽  
Asymmetric Reduction ◽  
Acid Ethyl Ester ◽  
Yeast Cells ◽  
Biotransformation Process ◽  
Set Up ◽  
Ethyl Benzoylformate

An efficient yeast cell biotransformation process was set up for asymmetric synthesis of (R)-(-)-mandelic acid ethyl ester, a key drug intermediate. Saccharomyces cerevisiae 21 was selected as optimum strain for biotransformation. The optimum reduction conditions are as follows: substrate concentration 20 g/L, cell concentration 140 g/L, reaction time 36 h, temperature 30 0C. Conversion and enantiometric excess of (R)-(-)-mandelic acid ethyl ester reached 99.8 % and 100%.

Whole Cell‐Based Cascade Biotransformation for the Production of ( S )‐Mandelic Acid from Styrene, L ‐Phenylalanine, Glucose, or Glycerol

2019 ◽  
Vol 361 (15) ◽  
pp. 3560-3568 ◽  
Author(s):  
Benedict Ryan Lukito ◽  
Balaji Sundara Sekar ◽  
Shuke Wu ◽  
Zhi Li
Keyword(s):  
Mandelic Acid ◽  
Whole Cell

Mandelic Acid as Synthetic Equivalent of Benzoyl Carbanion. Synthesis of Nitrobenzophenones

Synlett ◽  
2003 ◽  
pp. 2325-2328
Author(s):  
José R. Pedro ◽  
Gonzalo Blay ◽  
Luz Cardona ◽  
Isabel Fernández ◽  
Raquel Michelena ◽  
...  
Keyword(s):  
Mandelic Acid ◽  
Synthetic Equivalent
Sign in / Sign up

Export Citation Format

Share Document