Synthesis of (R)-(-)-Mandelic Acid Ethyl Ester by Asymmetric Reduction of Ethyl Benzoylformate with Yeast Cells
2012 ◽
Vol 560-561
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pp. 273-278
Keyword(s):
Set Up
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An efficient yeast cell biotransformation process was set up for asymmetric synthesis of (R)-(-)-mandelic acid ethyl ester, a key drug intermediate. Saccharomyces cerevisiae 21 was selected as optimum strain for biotransformation. The optimum reduction conditions are as follows: substrate concentration 20 g/L, cell concentration 140 g/L, reaction time 36 h, temperature 30 0C. Conversion and enantiometric excess of (R)-(-)-mandelic acid ethyl ester reached 99.8 % and 100%.
2010 ◽
Vol 27
(6)
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pp. 1841-1846
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Keyword(s):
2011 ◽
Vol 16
(2)
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pp. 320-326
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2006 ◽
Vol 14
(1)
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pp. 73-80
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Keyword(s):
2014 ◽
Vol 42
(3)
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pp. 477-486
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1996 ◽
Vol 7
(6)
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pp. 1571-1572
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Keyword(s):
2006 ◽
Vol 281
(7)
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pp. 4446-4456
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