A NOVEL SYNTHESIS OF PHOSPHORUS HETEROCYCLES. REACTION OF α -HYDRAZIDOYL HALIDES WITH PHOSPHORANES AND LAWESSON'S REAGENT

2004 ◽  
Vol 179 (3) ◽  
pp. 521-528 ◽  
Author(s):  
Nadia R. Mohamed ◽  
Manal M.T. El-Saidi ◽  
Hamdi M. Hassaneen ◽  
Ayman W. Erian
Keyword(s):  
Lawesson’S Reagent ◽  
Novel Synthesis ◽  
Hydrazidoyl Halides ◽  
Phosphorus Heterocycles ◽  
Lawesson's Reagent

Novel synthesis of oxa[9]helicenes by Lawesson’s reagent-mediated cyclization of helical quinone derivatives

2011 ◽  
Vol 52 (35) ◽  
pp. 4518-4520 ◽  
Author(s):  
Mohammad Salim ◽  
Akira Akutsu ◽  
Takao Kimura ◽  
Masahiro Minabe ◽  
Michinori Karikomi
Keyword(s):  
Lawesson’S Reagent ◽  
Novel Synthesis ◽  
Lawesson's Reagent

Thionation reactions of 2-pyrrole carboxylates

RSC Advances ◽  
2016 ◽  
Vol 6 (74) ◽  
pp. 69691-69697 ◽  
Author(s):  
Brandon R. Groves ◽  
Deborah A. Smithen ◽  
T. Stanley Cameron ◽  
Alison Thompson
Keyword(s):  
Elevated Temperatures ◽  
Lawesson’S Reagent ◽  
New Class ◽  
Lawesson's Reagent

Reaction of 2-pyrrole carboxylates with Lawesson's reagent at elevated temperatures results in the corresponding thionoesters, concurrent with the production of a new class of pyrrole annulated with the (1,3,2)-thiazaphospholidine unit.

Thioamide Derivative of the Potent Antitubercular 2-(Decylsulfonyl)acetamide is Less Active Against Mycobacterium tuberculosis, but a More Potent Antistaphylococcal Agent

2018 ◽  
Vol 71 (9) ◽  
pp. 716
Author(s):  
Hsien-Kuo Sun ◽  
Angel Pang ◽  
Dylan C. Farr ◽  
Tamim Mosaiab ◽  
Warwick J. Britton ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Mycobacterium Tuberculosis ◽  
Parent Compound ◽  
Gram Positive ◽  
Antibacterial Compounds ◽  
Lawesson’S Reagent ◽  
Lawesson's Reagent ◽  
Structural Simplicity

Due to the prevalence of thioamides in antibacterial compounds, we chose to convert the amide in the antitubercular compound 2-(decylsulfonyl)acetamide to a thioamide using Lawesson’s reagent to study its activity against a range of microorganisms. This derivative (8) had significantly diminished activity against tuberculosis but slightly better activity than the parent compound against the Gram positive species Staphylococcus aureus. This activity against a second major pathogen is remarkable considering the structural simplicity of these compounds.

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